Review
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Year 2022, Volume: 52 Issue: 2, 215 - 225, 30.08.2022
https://doi.org/10.26650/IstanbulJPharm.2022.1027027

Abstract

Project Number

TDK-2020-21680

References

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Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals

Year 2022, Volume: 52 Issue: 2, 215 - 225, 30.08.2022
https://doi.org/10.26650/IstanbulJPharm.2022.1027027

Abstract

The incidence of obesity and related diseases increased dramatically in the last decade. Some endocrine disruptors were shown to interact with metabolic processes via various cellular mechanisms, disrupt homeostasis in adipose tissue, resulting in weight gain and obesity. These chemicals are called “obesogens”. Today, with the increased use of industrial chemicals, individuals are exposed to a mixture of chemicals at very low doses. Most of these industrial chemicals have been investigated for their possible endocrine disrupting and obesogenic effects. Beside these chemicals, pharmaceuticals can also have similar adverse effects, however, limited studies have been performed to investigate such effects of drugs. Furthermore, there are few studies investigating the relationship between prenatal exposure to pharmaceuticals and childhood obesity. Therefore, to clarify the endocrine disrupting and obesogenic effects of the pharmaceuticals, which are prescribed during pregnancy, mechanistic studies should be performed, and necessary precautions should be taken. In this paper, we reviewed the mechanisms of obesogens, briefly overview several well-known obesogenic industrial chemicals and focused more on potential obesogenic pharmaceuticals.

Supporting Institution

EGE ÜNİVERSİTESİ BAP Koordinatörlüğü

Project Number

TDK-2020-21680

Thanks

Authors are thankful to Ege University Scientific Research Projects Coordination for supporting doctoral research of Bita ENTEZARI with the grant ID # TDK-2020-21680

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There are 117 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Review
Authors

Bıta Entezarı 0000-0003-1496-1091

Deniz Bozdağ This is me 0000-0003-3082-1582

Hande Gürer-orhan 0000-0002-4890-299X

Project Number TDK-2020-21680
Publication Date August 30, 2022
Submission Date November 23, 2021
Published in Issue Year 2022 Volume: 52 Issue: 2

Cite

APA Entezarı, B., Bozdağ, D., & Gürer-orhan, H. (2022). Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. İstanbul Journal of Pharmacy, 52(2), 215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027
AMA Entezarı B, Bozdağ D, Gürer-orhan H. Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. iujp. August 2022;52(2):215-225. doi:10.26650/IstanbulJPharm.2022.1027027
Chicago Entezarı, Bıta, Deniz Bozdağ, and Hande Gürer-orhan. “Obesogens: Definition, Mechanisms of Action, Potential Industrial Chemicals and Pharmaceuticals”. İstanbul Journal of Pharmacy 52, no. 2 (August 2022): 215-25. https://doi.org/10.26650/IstanbulJPharm.2022.1027027.
EndNote Entezarı B, Bozdağ D, Gürer-orhan H (August 1, 2022) Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. İstanbul Journal of Pharmacy 52 2 215–225.
IEEE B. Entezarı, D. Bozdağ, and H. Gürer-orhan, “Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals”, iujp, vol. 52, no. 2, pp. 215–225, 2022, doi: 10.26650/IstanbulJPharm.2022.1027027.
ISNAD Entezarı, Bıta et al. “Obesogens: Definition, Mechanisms of Action, Potential Industrial Chemicals and Pharmaceuticals”. İstanbul Journal of Pharmacy 52/2 (August 2022), 215-225. https://doi.org/10.26650/IstanbulJPharm.2022.1027027.
JAMA Entezarı B, Bozdağ D, Gürer-orhan H. Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. iujp. 2022;52:215–225.
MLA Entezarı, Bıta et al. “Obesogens: Definition, Mechanisms of Action, Potential Industrial Chemicals and Pharmaceuticals”. İstanbul Journal of Pharmacy, vol. 52, no. 2, 2022, pp. 215-2, doi:10.26650/IstanbulJPharm.2022.1027027.
Vancouver Entezarı B, Bozdağ D, Gürer-orhan H. Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals. iujp. 2022;52(2):215-2.