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Year 2020, Volume: 4 Issue: 2, 123 - 127, 01.06.2020
https://doi.org/10.30621/jbachs.2020.1010

Abstract

References

  • 1. Santos CR, Duarte AC, Quintela T, et al. The choroid plexus as a sex hormone target: Functional implications. Front Neuroendocrinol 2017;44:103–121. [CrossRef]
  • 2. Liddelow SA. Development of the choroid plexus and blood-CSF barrier. Front Neurosci 2015;9:32. [CrossRef]
  • 3. Lun MP, Monuki ES, Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system. Nat Rev Neurosci 2015;16:445–457. [CrossRef]
  • 4. Flores K, Manautou JE, Renfro JL. Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus. Toxicology 2017;386:84–92. [CrossRef]
  • 5. Hanamsagar R, Bilbo SD. Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development. J Steroid Biochem Mol Biol 2016;160:127–133. [CrossRef]
  • 6. Marques F, Sousa JC, Brito MA, et al. The choroid plexus in health and in disease: dialogues into and out of the brain. Neurobiol Dis 2017;107:32–40. [CrossRef]
  • 7. Koike S, Tanaka Y, Matsuzaki T, Morishita Y, Ishibashi K. Aquaporin-11 (AQP11) Expression in the Mouse Brain. Int J Mol Sci 2016;17:861. [CrossRef]
  • 8. Direito I, Madeira A, Brito MA, Soveral G. Aquaporin-5: from structure to function and dysfunction in cancer. Cell Mol Life Sci 2016;73:1623–1640. [CrossRef]
  • 9. Nakada T, Kwee IL. Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain. Neuroscientist 2019;25:155–166. [CrossRef]
  • 10. Jeon T, Park KS, Park SH, Hwang JH, Hwang SK. Expression of Aquaporin 1 and 4 in the Choroid Plexus and Brain Parenchyma of Kaolin-Induced Hydrocephalic Rats. Korean J Neurotrauma 2017;13:68–75. [CrossRef]
  • 11. Mobasheri A, Wray S, Marples D. Distribution of AQP2 and AQP3 water channels in human tissue microarrays. J Mol Histol 2005;36:1– 14. [CrossRef]
  • 12. Caligioni CS. Assessing reproductive status/stages in mice. Curr Protoc Neurosci 2009;48:A.4I.1-A.4I.8. [CrossRef]
  • 13. Paxinos G, Franklin K. Paxinos and Franklin’s the Mouse Brain in Stereotaxic Coordinates, 5th ed. USA: Elsevier Science; 2001.
  • 14. Verkman AS, Tradtrantip L, Smith AJ, Yao X. Aquaporin Water Channels and Hydrocephalus. Pediatr Neurosurg 2017;52:409–416. [CrossRef]
  • 15. Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nat Rev Neurosci 2013;14:265–277. [CrossRef]
  • 16. Tumani H, Huss A, Bachhuber F. The cerebrospinal fluid and barriers - anatomic and physiologic considerations. Handb Clin Neurol 2017;146:21–32. [CrossRef]
  • 17. Yang M, Gao F, Liu H, et al. Immunolocalization of aquaporins in rat brain. Anat Histol Embryol 2011;40:299–306. [CrossRef]
  • 18. Castaneyra-Ruiz L, Gonzalez-Marrero I, Hernandez-Abad LG, Carmona-Calero EM, Meyer G, Castaneyra-Perdomo A. A Distal to Proximal Gradient of Human Choroid Plexus Development, with Antagonistic Expression of Glut1 and AQP1 in Mature Cells vs. Calbindin and PCNA in Proliferative Cells. Front Neuroanat 2016;10:87. [CrossRef]
  • 19. Quek AM, McKeon A, Lennon VA, et al. Effects of age and sex on aquaporin-4 autoimmunity. Arch Neurol 2012;69:1039–1043. [CrossRef]
  • 20. Quintela T, Albuquerque T, Lundkvist G, et al. The choroid plexus harbors a circadian oscillator modulated by estrogens. Chronobiol Int 2018;35:270–279. [CrossRef]
  • 21. Herak-Kramberger CM, Breljak D, Ljubojevic M, et al. Sex-dependent expression of water channel AQP1 along the rat nephron. Am J Physiol Renal Physiol 2015;308:F809–F821. [CrossRef]
  • 22. Cheema MU, Irsik DL, Wang Y, et al. Estradiol regulates AQP2 expression in the collecting duct: a novel inhibitory role for estrogen receptor alpha. Am J Physiol Renal Physiol 2015;309:F305–F317. [CrossRef]
  • 23. Chinigarzadeh A, Muniandy S, Salleh N. Estradiol, progesterone and genistein differentially regulate levels of aquaporin (AQP)-1, 2, 5 and 7 expression in the uteri of ovariectomized, sex-steroid deficient rats. Steroids 2016;115:47–55. [CrossRef]
  • 24. Yaba A, Sozen B, Suzen B, Demir N. Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle. Morphologie 2017;101:39–46. [CrossRef]

Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?

Year 2020, Volume: 4 Issue: 2, 123 - 127, 01.06.2020
https://doi.org/10.30621/jbachs.2020.1010

Abstract

Background: It is known that sex hormones show modulatory effects on the central nervous system CNS . Various CNS pathologies show sex-related differences in terms of rates, symptoms, and the course of the disease. Some of the functions of choroid plexus CP are under the control of sex hormones. The aim of this descriptive study was to evaluate sex effects on CP water channels. Methods: Expressions of Aquaporin AQP 1, 2 and 4 proteins in CP were compared between in male and female Balb/C mice brains; and also in different stages of the estrous cycle, with immunohistochemistry. Results: No difference is observed for AQP 1, 2 and 4 immunoreactivities in male and female brain, including different stages of the estrous cycle. Conclusion: In conclusion, to the best of our knowledge, AQP2 expression was shown in the CP for the first time, and no sex hormonedependent differences were found in terms of expressions of AQP1, 2 and 4.

References

  • 1. Santos CR, Duarte AC, Quintela T, et al. The choroid plexus as a sex hormone target: Functional implications. Front Neuroendocrinol 2017;44:103–121. [CrossRef]
  • 2. Liddelow SA. Development of the choroid plexus and blood-CSF barrier. Front Neurosci 2015;9:32. [CrossRef]
  • 3. Lun MP, Monuki ES, Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system. Nat Rev Neurosci 2015;16:445–457. [CrossRef]
  • 4. Flores K, Manautou JE, Renfro JL. Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus. Toxicology 2017;386:84–92. [CrossRef]
  • 5. Hanamsagar R, Bilbo SD. Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development. J Steroid Biochem Mol Biol 2016;160:127–133. [CrossRef]
  • 6. Marques F, Sousa JC, Brito MA, et al. The choroid plexus in health and in disease: dialogues into and out of the brain. Neurobiol Dis 2017;107:32–40. [CrossRef]
  • 7. Koike S, Tanaka Y, Matsuzaki T, Morishita Y, Ishibashi K. Aquaporin-11 (AQP11) Expression in the Mouse Brain. Int J Mol Sci 2016;17:861. [CrossRef]
  • 8. Direito I, Madeira A, Brito MA, Soveral G. Aquaporin-5: from structure to function and dysfunction in cancer. Cell Mol Life Sci 2016;73:1623–1640. [CrossRef]
  • 9. Nakada T, Kwee IL. Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain. Neuroscientist 2019;25:155–166. [CrossRef]
  • 10. Jeon T, Park KS, Park SH, Hwang JH, Hwang SK. Expression of Aquaporin 1 and 4 in the Choroid Plexus and Brain Parenchyma of Kaolin-Induced Hydrocephalic Rats. Korean J Neurotrauma 2017;13:68–75. [CrossRef]
  • 11. Mobasheri A, Wray S, Marples D. Distribution of AQP2 and AQP3 water channels in human tissue microarrays. J Mol Histol 2005;36:1– 14. [CrossRef]
  • 12. Caligioni CS. Assessing reproductive status/stages in mice. Curr Protoc Neurosci 2009;48:A.4I.1-A.4I.8. [CrossRef]
  • 13. Paxinos G, Franklin K. Paxinos and Franklin’s the Mouse Brain in Stereotaxic Coordinates, 5th ed. USA: Elsevier Science; 2001.
  • 14. Verkman AS, Tradtrantip L, Smith AJ, Yao X. Aquaporin Water Channels and Hydrocephalus. Pediatr Neurosurg 2017;52:409–416. [CrossRef]
  • 15. Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nat Rev Neurosci 2013;14:265–277. [CrossRef]
  • 16. Tumani H, Huss A, Bachhuber F. The cerebrospinal fluid and barriers - anatomic and physiologic considerations. Handb Clin Neurol 2017;146:21–32. [CrossRef]
  • 17. Yang M, Gao F, Liu H, et al. Immunolocalization of aquaporins in rat brain. Anat Histol Embryol 2011;40:299–306. [CrossRef]
  • 18. Castaneyra-Ruiz L, Gonzalez-Marrero I, Hernandez-Abad LG, Carmona-Calero EM, Meyer G, Castaneyra-Perdomo A. A Distal to Proximal Gradient of Human Choroid Plexus Development, with Antagonistic Expression of Glut1 and AQP1 in Mature Cells vs. Calbindin and PCNA in Proliferative Cells. Front Neuroanat 2016;10:87. [CrossRef]
  • 19. Quek AM, McKeon A, Lennon VA, et al. Effects of age and sex on aquaporin-4 autoimmunity. Arch Neurol 2012;69:1039–1043. [CrossRef]
  • 20. Quintela T, Albuquerque T, Lundkvist G, et al. The choroid plexus harbors a circadian oscillator modulated by estrogens. Chronobiol Int 2018;35:270–279. [CrossRef]
  • 21. Herak-Kramberger CM, Breljak D, Ljubojevic M, et al. Sex-dependent expression of water channel AQP1 along the rat nephron. Am J Physiol Renal Physiol 2015;308:F809–F821. [CrossRef]
  • 22. Cheema MU, Irsik DL, Wang Y, et al. Estradiol regulates AQP2 expression in the collecting duct: a novel inhibitory role for estrogen receptor alpha. Am J Physiol Renal Physiol 2015;309:F305–F317. [CrossRef]
  • 23. Chinigarzadeh A, Muniandy S, Salleh N. Estradiol, progesterone and genistein differentially regulate levels of aquaporin (AQP)-1, 2, 5 and 7 expression in the uteri of ovariectomized, sex-steroid deficient rats. Steroids 2016;115:47–55. [CrossRef]
  • 24. Yaba A, Sozen B, Suzen B, Demir N. Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle. Morphologie 2017;101:39–46. [CrossRef]
There are 24 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Berna Sözen This is me

Güneş Aytaç

Necdet Demir This is me

Bikem Süzen This is me

Gamze Tanrıöver This is me

Publication Date June 1, 2020
Published in Issue Year 2020 Volume: 4 Issue: 2

Cite

APA Sözen, B., Aytaç, G., Demir, N., Süzen, B., et al. (2020). Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?. Journal of Basic and Clinical Health Sciences, 4(2), 123-127. https://doi.org/10.30621/jbachs.2020.1010
AMA Sözen B, Aytaç G, Demir N, Süzen B, Tanrıöver G. Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?. JBACHS. June 2020;4(2):123-127. doi:10.30621/jbachs.2020.1010
Chicago Sözen, Berna, Güneş Aytaç, Necdet Demir, Bikem Süzen, and Gamze Tanrıöver. “Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?”. Journal of Basic and Clinical Health Sciences 4, no. 2 (June 2020): 123-27. https://doi.org/10.30621/jbachs.2020.1010.
EndNote Sözen B, Aytaç G, Demir N, Süzen B, Tanrıöver G (June 1, 2020) Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?. Journal of Basic and Clinical Health Sciences 4 2 123–127.
IEEE B. Sözen, G. Aytaç, N. Demir, B. Süzen, and G. Tanrıöver, “Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?”, JBACHS, vol. 4, no. 2, pp. 123–127, 2020, doi: 10.30621/jbachs.2020.1010.
ISNAD Sözen, Berna et al. “Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?”. Journal of Basic and Clinical Health Sciences 4/2 (June 2020), 123-127. https://doi.org/10.30621/jbachs.2020.1010.
JAMA Sözen B, Aytaç G, Demir N, Süzen B, Tanrıöver G. Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?. JBACHS. 2020;4:123–127.
MLA Sözen, Berna et al. “Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?”. Journal of Basic and Clinical Health Sciences, vol. 4, no. 2, 2020, pp. 123-7, doi:10.30621/jbachs.2020.1010.
Vancouver Sözen B, Aytaç G, Demir N, Süzen B, Tanrıöver G. Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?. JBACHS. 2020;4(2):123-7.