Investigation of polypharmacy and potential drug-drug interactions in a group of hospitalized pediatric patients: a single-center study

Year 2024, Volume: 7 Issue: 2, 153 - 159, 25.03.2024

Jale Akgöl Ayşegül Bükülmez

https://doi.org/10.32322/jhsm.1414787

Abstract

Aims: Polypharmacy involves the use of multiple medications to manage one or more clinical conditions. This study aimed to determine the prevalence of polypharmacy and potential drug-drug interactions during hospitalizations in childhood and to investigate the nature of common interactions.
Methods: Data for this retrospective cross-sectional observational study were obtained from the hospital database records of pediatric patients admitted to the pediatric department of a university hospital during the first six months of 2020. A total of 601 pediatric prescriptions from 877 hospitalizations involving 2620 medications were examined for drug-drug interactions using the drugs.com/interaction checker tool.
Results: Of the evaluated 601 patients, 48.1% were female and 51.9% were male children. The mean age of the hospitalized patients was 4.78±5.2 years, ranging from 0 to 18 years, with a median age of 2 years. The mean length of the hospital stay was 5.5 (min 1-max 56) days. The mean number of prescribed medications per child was 4.38±2.4 (min-max 1-16). Potential interactions were identified in 49.1% of the prescriptions. The prescription rate of antimicrobial treatment for hospitalized patients was 86%, and this group had a high occurrence of major drug-drug interactions (p<0.05). Patients taking multiple
medications had significantly longer hospital stays (p<0.05). Clarithromycin and ceftriaxone are among the most commonly interacting drugs.
Conclusion: The use of multiple drugs is common among hospitalized pediatric patients. There is a high risk of interaction during multiple antimicrobial treatments, especially in tertiary care hospitals. The increased risk of interactions associated with specific drug groups should prompt clinicians to make informed decisions when prescribing drugs.

Keywords

Polypharmacy, Pediatrics, Hospitalized patients, Drug- drug interactions

Ethical Statement

This study was initiated after the decision of the Afyonkarahisar University Clinical Researches Local Ethics Committee 02.10.2020–2020/12–442.

Supporting Institution

The authors declared that this study has received no financial support.

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