Examination of the possible effects of ozone application in Duchenne muscular dystrophy

Year 2024, Volume: 3 Issue: 1, 8 - 13, 29.03.2024

Zeynep Yüce Yasan

Abstract

Duchenne muscular dystrophy (DMD), an X-linked disorder, has an incidence of one in 5000 boys and presents in early childhood with proximal muscle weakness. The disease is caused by mutations in DMD (encoding dystrophin) that abolish the production of dystrophin in muscle. In this study, we aimed to investigate the effect of ozone therapy (OT) on muscle oxygenation in DMD patients. For this purpose, DMD was developed in the primary skeletal muscle cell line. The changes that occurred by administering OT to the cell lines were observed. OT reduced mitochondrial ROS caused by DMD, partially improved the shape changes in myoblasts, but had no effect on dystrophin. OT to DMD patients may have a positive effect on muscle cells.

Keywords

Duchenne muscular dystrophy, mitochondrial ROS, ozone therapy

References

• 1. Üsküdar Health Services Vocational School - "About Electroneurophysiology, Access: September 6, 2023. https://uskudar.edu.tr/shmyo/elektronorofizyoloji
• 2. Turkey Clinics "Neurology Journal," Access: September 6, 2023. https://www.turkiyeklinikleri.com/journal/noroloji-dergisi/1304-0537/tr-index.html
• 3. Ummuhan Işoğlu Alkaç, Clinical Development "A Stroll in the History of Brain Research: Electroneurophysiology," Access: September 7, 2023. https://www.klinikgelisim.org.tr/kg22_3/3.pdf
• 4. Betül Baykan, Istanbul Faculty of Medicine, "Electroencephalography," Access: September 7, 2023. http://www.itfnoroloji.org/semi2/eeg.htm
• 5. Medicana, “What is EEG?” Access: September 7, 2023. https://www.medicana.com.tr/saglik-rehberi-detay/17953/eeg-nedir
• 6. Acıbadem "What is EEG," Access: September 8, 2023. https://www.acibadem.com.tr/hayat/eeg-nedir/
• 7. About EEG, "Types of EEG" Access: September 8, 2023. https://eeguzerine.com/i_eeg-cesitleri.html
• 8. About EEG, "Routine EEG" Access: September 9, 2023. https://eeguzerine.com/i_rutin-eeg.html
• 9. About EEG, "EEG Electroencephalography" Access: September 9, 2023. https://eeguzerine.com/i_eeg_elektroensefalografi.html
• 10. Canan Kocaman "What is Electroencephalography (EEG)?" Access: September 9, 2023. https://www.canankocaman.com/elektroensefalografi-eeg-nedir
• 11. TR Presidency Legislation Information System "Regulation on Job Descriptions and Duties of Healthcare Professionals and Other Healthcare Workers," Access: September 9, 2023. https://www.mevzuat.gov.tr/mevzuat?MevzuatNo=19696&MevzuatTur=7&MevzuatTertip=5
• 12. "Lifemed "What Are the Types of EEG" Access: September 10, 2023. https://www.lifemed.com.tr/blog/eegnin-cesitleri-nelerdir/
• 13. "Medipol University - Istanbul "Electroneurophysiology," Access: September 11, 2023. https://www.medipol.edu.tr/akademik/meslek-yuksekokullari/saglik-hizmetleri-meslek-yuksekokulu/bolumler/elektronorofizyoloji
• 14. "Biruni University "Electroneurophysiology," Access: September 12, 2023. https://myo.biruni.edu.tr/index.php/myo-elektronorofizyoloji/