PANKREATİTLİ ÇOCUKLARDA HEMATOLOJİK PARAMETRELERİN KLİNİK ÖNEMİ

Year 2024, Volume: 25 Issue: 1 - OCAK 2024 SAYISI, 37 - 42, 17.01.2024

Ayşegül Bükülmez Özge Vural Ahmet Ali Tuncer

https://doi.org/10.18229/kocatepetip.1056282

Abstract

AMAÇ: Bu çalışmada, akut pankreatit (AP) ve akut rekürren
pankreatit (ARP) tanısı alan çocuklarda akut pankreatitin inflamatuar
sürecinde tanıda yeni hematolojik parametrelerin önemini
retrospektif olarak değerlendirmeyi amaçladık. Bu çalışma
pankreatitli çocuklarda yeni hematolojik parametreleri; (eritrosit
dağılım genişliği (RDW), eritrosit dağılım genişliği kalsiyum
oranı (RDWCaR), nötrofil lenfosit oranı (NLR), lenfosit monosit
oranı (LMR), trombosit lenfosit oranı (PLR), eritrosit dağılım
genişliği trombosit oranı (RDWPR), ortalama trombosit hacmi
(MPV))'ni retrospektif olarak değerlendiren literatürdeki ilk çalışmadır.
GEREÇ VE YÖNTEM: Ocak 2014 - Aralık 2019 tarihleri arasında
hastaneye başvuran ve AP ve ARP tanısı alan 55 hastanın tıbbi
kayıtları geriye dönük olarak incelendi. 0 ve 48. saatlerde RDW,
RDWCaR, MPVPR, NLR, LMR, RDWPR ve PLR değerleri geriye dönük
olarak değerlendirildi. Grup 1 akut pankreatit, Grup 2 akut
rekürren pankreatit hastalardan oluşmaktadır. İstatistiksel olarak
p<0,05 değeri anlamlı kabul edildi.
BULGULAR: Grup 1 ve Grup 2'nin RDW48h değerleri, RDW0h değerlerinden
anlamlı derecede düşük bulundu (sırasıyla p<0,001
ve p=0,006). Her iki grupta da RDWCaR48h değerleri de RDWCaR0h'den
anlamlı derecede düşük bulundu (sırasıyla p= 0,003
ve p= 0,012). Grup 1'de NLR48h değeri NLR0h'den düşük saptandı
(p= 0,004). Ayrıca Grup 2'de RDWPR48h değeri RDWPR0h'ye göre
daha düşük bulundu (p=0,041).
SONUÇ: Bu çalışmada AP ve ARP'li çocukların tanı ve takibinde
ilk 48 saat içindeki RDW, RDWCaR, NLR ve RDWPR değerlerinin
önemli olduğunu belirledik.

Keywords

Eritrosit dağılım genişliği, Pankreatit, Çocuk.

CLINICAL SIGNIFICANCE OF HEMATOLOGICAL PARAMETERS IN CHILDREN WITH PANCREATITIS

Abstract

OBJECTIVE: In this study, we aimed to retrospectively evaluate
the significance of new hematological parameters in the
diagnosis of the inflammatory process of acute pancreatitis in
children diagnosed with acute pancreatitis (AP) and acute recurrent
pancreatitis (ARP). This is the first study in the literature
assessing new hematological parameters (Red cell distribution
width (RDW), red cell distribution width to calcium ratio (RDWCaR),
neutrophile to lymphocyte ratio (NLR), lymphocyte to monocyte
ratio (LMR), platelet to lymphocyte ratio (PLR), Red cell
distribution width to platelet ratio (RDWPR) and mean platelet
volume (MPV)) in children with pancreatitis retrospectively.
MATERIAL AND METHODS: The medical records of 55 patients,
who were admitted to the hospital between January 2014 and
December 2019 were diagnosed with AP and ARP, were examined
retrospectively. RDW, RDWCaR, MPV, NLR, LMR, RDWPR and
PLR values at 0 and 48 hours were evaluated retrospectively.
Group 1 consists of patients with acute pancreatitis, Group 2
consists of patients with acute recurrent pancreatitis. A p value
of <0.05 was considered statistically significant.
RESULTS: RDW48h values of Group 1 and Group 2 were found to
be significantly lower than RDW0h values (p<0.001 and p=0.006,
respectively). RDWCaR48h values in both groups were also found
to be significantly lower than RDWCaR0h (p= 0.003 and p=
0.012, respectively). NLR48h value was detected to be lower than
NLR0h in Group 1 (p= 0.004). Moreover, the RDWPR48h value was
found to be lower compared to RDWPR0h in Group 2 (p=0.041).
CONCLUSIONS: In this study, we determined that RDW, RDWCaR,
NLR and RDWPR values within the first 48 hours were important
in the diagnosis and follow-up of children with AP and
ARP.

Keywords

Red cell distribution width, Pancreatitis, Children

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