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A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release

Year 2014, Volume: 18 Issue: 3, 101 - 108, 12.09.2014

Abstract

In this study, the controlled release tablet of diltiazem

hydrochloride was developed. The controlled release

tablets were prepared with ethyl cellulose by changing

the ratio of diltiazem hydrochloride and the in vitro

release studies were carried out by using an ultrasonic

water bath. According to release results, a new equation

was developed that can be used to estimate the release of

drug as a function of time and drug content in the

formulation. In addition, the effect of ultrasound on the

release of diltiazem hydrochloride from controlled

release dosage forms and relationships between release

rate constants and drug contents were investigated. This

study showed that the developed equation can

successfully be used to estimate the effect of ultrasound

on the release of drug from the formulations prepared

with different concentrations of diltiazem hydrochloride.

It was concluded that ultrasound has a very important

effect on the release of drug and increases drug release

obviously.

Keywords: ultrasound; controlled release; pulsatile

release

References

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  • Jeong SY, Kim SW, Holmberg DL, McRea JC. Self-regulating insulin delivery systems:III.In vivo studies. J Control Release 1985;2:143-52.
  • Kwon IC, Bae YH, Kim SW. Electrically erodible polymer gel for controlled release of drugs. Nature 1991;354:291-93.
  • Tanaka T, Nishio I, Sun ST, Ueno-Nishio S. Colapse of gels in an electric field. Science 1982;218: 467-69.
  • Grimshaw PE, Grodzinsky AJ, Yarmush ML, Yarmush DM. Dynamic membranes for membranes for protein transport: chemical and electrical control. Chem Eng Sci 1989;44:827-40.
  • Brownlee M, Cerami A. A glucose controlled insulin delivery system: semisynthetic insulin bound to lectin. Science 1979;206:1190-91.
  • Kim SW, Paii CM, Kimiko M, Seminoff AL, Holmberg DL, Gleeson JM, Wilson DE, Mack EJ. Self-regulated glycosylated insulin delivery. J Control Release 1990; 11: 193-201.
  • Hsieh DST, Langer R, Folkman J. Magnetic modulation of release of macromolecules from polymers. Proc Natl Acad Sci USA 1981;78:1863-67.
  • D’Emanuele A, Kost Y, Hill J. An investigation of the effects of ultrasound on degradable polyanhydride matrices. Macromolecules 1992;25:511- 5.
  • D’Emanuele A. Responsive polymeric drug delivery systems. Meeting the patient’s needs. Clin Pharmacokinet 1996;31:241- 45.
  • Kost J, Leong K, Langer R. Ultrasound- enhanced polymer degradation and release of incorporated substances. Proc Natl Acad Sci USA 1989;86:7663- 6.
  • Miyazaki S, Hou WM, Takada M. Controlled drug release by ultrasound irradiation. Chem Pharm Bull 1985;33:428-31.
  • Huang S. Liposomes in ultrasonic drug and gene delivery. Adv Drug Delivery Rev 2008;60:1167–76.
  • Frenkel V. Ultrasound mediated delivery of drugs and genes to solid tumors. Adv Drug Delivery Rev 2008;60:1193–08.
  • Mannaris C, Averkiou MA. Investigation of Microbubble Response to Long Pulses Used in Ultrasound-Enhanced Drug Delivery. Ultrasound Med Biol 2012;38:681–91.
  • Kooimana K, Böhmerb MR, Emmera M Vosa HJ, Chlonb C, Shic WT, Hallc CS, Winterb S, Schroënd K, Versluis M, Jonga N, Wamel A. Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs. J Controll Release 2009;133: 109–18.
  • Yanga F, Wongb T, Tenga M, Liua R, Lue M, Liange H, Weie M. Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme. J Controll Release 2012; 160:652–58.
  • Aw MS, Losic D. Ultrasound enhanced release of therapeutics from drug-releasing implants based on titania nanotube arrays. Int J Pharm 2013;443:154– 62.
  • Zilberman M, Kraitzer A, Grinberg O, Elsner JJ. Drug-eluting medical implants. Hand Exp Pharmacol 2010;197:299–341.
  • Gulati K, Ramakrishnan S, Aw MS, Atkins GJ, Findlay DM, Losic D. Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion. Acta Biomater 2012;8:449–56.
  • Aw MS, Addai-Mensah J, Losic D. Magnetic-responsive delivery of drug carriers using titania nanotube arrays. J Mater Chem 2012;22:6561–63.
  • Schlicher RK, Radhakrishna H, Tolentino TP, Apkarian RP, Zarnitsyn V, Prausnitz MR. Sonoporation by low-frequency and low-power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro. Ultrasound Med Biol 2006;32:915-24.
  • Huang SL, MacDonald RC. Acoustically active liposomes for drug encapsulation and ultrasound-triggered release. Biochem Biophys Acta 2004;1665:134–41.
  • Gao ZG, Fain HD, Rapoport N. Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound. J Control Release 2005;102:203–22.

ORIGINAL RESEARCH

Year 2014, Volume: 18 Issue: 3, 101 - 108, 12.09.2014

Abstract

References

  • Brownlee M, Cerami A. A glucose controlled insulin delivery system: semisynthetic insulin bound to lectin. Science 1979;206:1190-91.
  • Jeong SY, Kim SW, Holmberg DL, McRea JC. Self-regulating insulin delivery systems:III.In vivo studies. J Control Release 1985;2:143-52.
  • Kwon IC, Bae YH, Kim SW. Electrically erodible polymer gel for controlled release of drugs. Nature 1991;354:291-93.
  • Tanaka T, Nishio I, Sun ST, Ueno-Nishio S. Colapse of gels in an electric field. Science 1982;218: 467-69.
  • Grimshaw PE, Grodzinsky AJ, Yarmush ML, Yarmush DM. Dynamic membranes for membranes for protein transport: chemical and electrical control. Chem Eng Sci 1989;44:827-40.
  • Brownlee M, Cerami A. A glucose controlled insulin delivery system: semisynthetic insulin bound to lectin. Science 1979;206:1190-91.
  • Kim SW, Paii CM, Kimiko M, Seminoff AL, Holmberg DL, Gleeson JM, Wilson DE, Mack EJ. Self-regulated glycosylated insulin delivery. J Control Release 1990; 11: 193-201.
  • Hsieh DST, Langer R, Folkman J. Magnetic modulation of release of macromolecules from polymers. Proc Natl Acad Sci USA 1981;78:1863-67.
  • D’Emanuele A, Kost Y, Hill J. An investigation of the effects of ultrasound on degradable polyanhydride matrices. Macromolecules 1992;25:511- 5.
  • D’Emanuele A. Responsive polymeric drug delivery systems. Meeting the patient’s needs. Clin Pharmacokinet 1996;31:241- 45.
  • Kost J, Leong K, Langer R. Ultrasound- enhanced polymer degradation and release of incorporated substances. Proc Natl Acad Sci USA 1989;86:7663- 6.
  • Miyazaki S, Hou WM, Takada M. Controlled drug release by ultrasound irradiation. Chem Pharm Bull 1985;33:428-31.
  • Huang S. Liposomes in ultrasonic drug and gene delivery. Adv Drug Delivery Rev 2008;60:1167–76.
  • Frenkel V. Ultrasound mediated delivery of drugs and genes to solid tumors. Adv Drug Delivery Rev 2008;60:1193–08.
  • Mannaris C, Averkiou MA. Investigation of Microbubble Response to Long Pulses Used in Ultrasound-Enhanced Drug Delivery. Ultrasound Med Biol 2012;38:681–91.
  • Kooimana K, Böhmerb MR, Emmera M Vosa HJ, Chlonb C, Shic WT, Hallc CS, Winterb S, Schroënd K, Versluis M, Jonga N, Wamel A. Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs. J Controll Release 2009;133: 109–18.
  • Yanga F, Wongb T, Tenga M, Liua R, Lue M, Liange H, Weie M. Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme. J Controll Release 2012; 160:652–58.
  • Aw MS, Losic D. Ultrasound enhanced release of therapeutics from drug-releasing implants based on titania nanotube arrays. Int J Pharm 2013;443:154– 62.
  • Zilberman M, Kraitzer A, Grinberg O, Elsner JJ. Drug-eluting medical implants. Hand Exp Pharmacol 2010;197:299–341.
  • Gulati K, Ramakrishnan S, Aw MS, Atkins GJ, Findlay DM, Losic D. Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion. Acta Biomater 2012;8:449–56.
  • Aw MS, Addai-Mensah J, Losic D. Magnetic-responsive delivery of drug carriers using titania nanotube arrays. J Mater Chem 2012;22:6561–63.
  • Schlicher RK, Radhakrishna H, Tolentino TP, Apkarian RP, Zarnitsyn V, Prausnitz MR. Sonoporation by low-frequency and low-power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro. Ultrasound Med Biol 2006;32:915-24.
  • Huang SL, MacDonald RC. Acoustically active liposomes for drug encapsulation and ultrasound-triggered release. Biochem Biophys Acta 2004;1665:134–41.
  • Gao ZG, Fain HD, Rapoport N. Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound. J Control Release 2005;102:203–22.
There are 24 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Yelda Komesli

Emel Çetin This is me

Levent Kırılmaz This is me

Evren Gündoğdu This is me

Publication Date September 12, 2014
Published in Issue Year 2014 Volume: 18 Issue: 3

Cite

APA Komesli, Y., Çetin, E., Kırılmaz, L., Gündoğdu, E. (2014). A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release. Marmara Pharmaceutical Journal, 18(3), 101-108. https://doi.org/10.12991/mpj.2014187236
AMA Komesli Y, Çetin E, Kırılmaz L, Gündoğdu E. A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release. Marmara Pharm J. November 2014;18(3):101-108. doi:10.12991/mpj.2014187236
Chicago Komesli, Yelda, Emel Çetin, Levent Kırılmaz, and Evren Gündoğdu. “A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release”. Marmara Pharmaceutical Journal 18, no. 3 (November 2014): 101-8. https://doi.org/10.12991/mpj.2014187236.
EndNote Komesli Y, Çetin E, Kırılmaz L, Gündoğdu E (November 1, 2014) A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release. Marmara Pharmaceutical Journal 18 3 101–108.
IEEE Y. Komesli, E. Çetin, L. Kırılmaz, and E. Gündoğdu, “A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release”, Marmara Pharm J, vol. 18, no. 3, pp. 101–108, 2014, doi: 10.12991/mpj.2014187236.
ISNAD Komesli, Yelda et al. “A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release”. Marmara Pharmaceutical Journal 18/3 (November 2014), 101-108. https://doi.org/10.12991/mpj.2014187236.
JAMA Komesli Y, Çetin E, Kırılmaz L, Gündoğdu E. A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release. Marmara Pharm J. 2014;18:101–108.
MLA Komesli, Yelda et al. “A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release”. Marmara Pharmaceutical Journal, vol. 18, no. 3, 2014, pp. 101-8, doi:10.12991/mpj.2014187236.
Vancouver Komesli Y, Çetin E, Kırılmaz L, Gündoğdu E. A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release. Marmara Pharm J. 2014;18(3):101-8.