Clinical Research
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Do Choroidal Melanocytes Affect Choroidal Thickness in Patients with Newly Diagnosed Vitiligo?

Year 2022, Volume: 6 Issue: 3, 404 - 409, 27.12.2022
https://doi.org/10.29058/mjwbs.1122056

Abstract

Aim: Vitiligo is a chronic skin disease and considered to be an autoimmune, neural, and autocytotoxic
pathophysiology in which mainly the melanocytes in the epidermis are focused and destroyed.
Therefore, alterations in the choroid and retinal pigment epithelium are expected, and there are very
few publications using modern technology in research of this subject.
This study aimed to examine the optic disc, retinal nerve fiber layer (RNFL), and choroidal thickness
in patients with vitiligo by spectral-domain optical coherence tomography (SD-OCT) as a prospective
observational study.
Material and Methods: This single-center prospective cross-sectional study included 40 eyes of 40
patients with vitiligo and 42 eyes of 42 healthy individuals. The RNFL thickness, choroidal thickness,
and optic disc parameters (rim area, disc area, and cup volume) were compared between the two
groups.
Results: The study consisted of 21 female and 19 male in the vitiligo group, and 21 female and 21
male in controls; no difference was found in gender distribution between two groups (p=0.836). Vitiligo
and control groups had similar optic disc parameters, and RNFL and choroidal thicknesses; so the
differences in the mentioned parameters did not differ statistically (p>0.05 for all).
Conclusion: Vitiligo patients’ optic disc parameters, and RNFL and choroidal thicknesses did not differ
from those in healthy individuals. Based on unknown pathogenesis, the melanocytes at the choroidal
region may have compensatory mechanisms in vitiligo.

References

  • 1 Alikhan A, Felsten LM, Daly M, et al. Vitiligo: acomprehensive overview part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol 2011;65:473–491.
  • 2 Albert DM, Wagoner MD, Pruett RC, et al. Vitiligo and disorders of the RPE. Br J Ophthalmol 1983;67:153–156.
  • 3 Biswas G, Barbhuiya JN, Biswas MC, et al. Clinical pattern of ocular manifestations in vitiligo. J Indian Med Assoc 2003;101:478–480.
  • 4 Karadag R, Esmer O, Karadag AS, et al. Evaluation of ocular findings in patients with vitiligo. Int J Dermatol 2016;55:351–355.
  • 5 Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29:144–168.
  • 6 Ilhan N, Rifaioglu EN, Ilhan O, et al. Retinal Pigment Epithelium Thickness Analysis with Optical Coherence Tomography in Patients with Vitiligo. Med Sci 2015;31:587–591.
  • 7 Demirkan S, Onaran Z, Samav G et al. Decreased choroidal thickness in vitiligo patients. BMC Ophthalmol 2018;18:126.
  • 8 Wagoner MD, Albert DM, Lerner AB. Ocular abnormalities occuring with vitiligo. Ophthalmol 1978; 86:1145–1160.
  • 9 Nordlund JJ, Taylor NT, Albert DM, et al. The prevalence of vitiligo and poliosis in patients with uveitis. J Am Acad Dermatol 1981;4:528-536.
  • 10 Albert DM. Melanoma, vitiligo, and uveitis. Ophthalmology 2010;117:643-644.
  • 11 Aydin R, Ozsutcu M, Erdur SK, et al. The assessment of macular electrophysiology and macular morphology in patients with vitiligo. Int Ophthalmol 2018;38:233-239.
  • 12 Plonka PM, Passeron T, Brenner M, et al. What are melanocytes really doing all day long...? Exp Dermatol 2009;18:799-819.
  • 13 Cook CS, Ozanis V, Jakobiec FA. Prenatal development of the eye and its adnexa. In: Tasman W, editor. Duane’s Ophthalmology. Philadelphia: Lippincot-Raven Publishers, Inc, 1991:1–93.
  • 14 Mrejen S, Spaide RF. Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol 2013;58:387-429.
  • 15 Shibuya H, Watanabe R, MaenoA, et al. Melanocytes contribute to the vasculature of the choroid. Genes Genet Syst 2018;15;93:51-58.
  • 16 Adini I, Adini A, Bazinet L, et al. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB J 2015;29:662-670.
  • 17 Le Poole IC, Das PK, van den Wijngaard RM, et al. Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 1993;2:145–153.
  • 18 Sandoval-Cruz M, García-Carrasco M, Sánchez-Porras R, et al. Immunopathogenesis of vitiligo. Autoimmun Rev 2011;10:762–765. 19 Richmond JM, Frisoli ML, Harris JE. Innate immune mechanisms in vitiligo: danger from within. Curr Opin Immunol 2013;25:676–682.
  • 20 Whitton ME, Pinart M, Batchelor J, et al. Interventions for vitiligo. Cochrane Database Syst Rev 2010;1:CD003263.
  • 21 Örnek N, Onaran Z, Koçak M, et al. Retinal nerve fiber layer thickness in vitiligo patients. J Res Med Sci 2013;18:405-407.
  • 22 Öncül H, Ayhan E. Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients. J Cosmet Dermatol. 2020;00:1–6.

Vitiligo Tanısı Yeni Konulan Hastalarda Koroid Melanositleri Koroid Kalınlıklarını Etkiler mi?

Year 2022, Volume: 6 Issue: 3, 404 - 409, 27.12.2022
https://doi.org/10.29058/mjwbs.1122056

Abstract

Amaç: Vitiligo, kronik bir deri hastalığıdır ve esas olarak epidermisteki melanositlerin hedef alındığı ve yok edildiği otoimmün, nöral ve otositotoksik bir patofizyoloji olarak kabul edilir. Bu nedenle koroidde ve retina pigment epitelinde değişiklikler beklenir ve bu konuda modern teknolojiyi kullanan çok az yayın mevcuttur
Gereç ve Yöntem: Bu çalışmada vitiligolu hastalarda optik disk, retina sinir lifi tabakası (RSLT) ve koroid kalınlığının spektral alan optik koherens tomografi (SD-OKT) ile incelenmesi prospektif gözlemsel bu çalışma amaçlandı. Bu tek merkezli prospektif kesitsel çalışmaya vitiligolu 40 hastanın 40 gözü ve 42 sağlıklı bireyin 42 gözü dahil edildi. RSLT kalınlığı, koroid kalınlığı ve optik disk parametreleri (rim alanı, disk alanı ve cup hacmi) iki grup arasında karşılaştırıldı.
Bulgular: Çalışmaya vitiligo grubunda 21 kadın ve 19 erkek, kontrol grubunda 21 kadın ve 21 erkek; iki grup arasında cinsiyet dağılımı açısından fark bulunmadı (p=0,836). Vitiligo ve kontrol gruplarında benzer optik disk parametreleri, RSLT ve koroid kalınlıkları; yani bahsedilen parametrelerdeki farklılıklar istatistiksel olarak farklı değildi (tümü için p>0.05).
Sonuç: Vitiligo hastalarının optik disk parametreleri, RSLT ve koroid kalınlıkları sağlıklı bireylerden farklı değildi. Bilinmeyen bir patogeneze bağlı olarak, koroid bölgesindeki melanositlerin vitiligoda kendini telafi edici mekanizmaları olabilir.

References

  • 1 Alikhan A, Felsten LM, Daly M, et al. Vitiligo: acomprehensive overview part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol 2011;65:473–491.
  • 2 Albert DM, Wagoner MD, Pruett RC, et al. Vitiligo and disorders of the RPE. Br J Ophthalmol 1983;67:153–156.
  • 3 Biswas G, Barbhuiya JN, Biswas MC, et al. Clinical pattern of ocular manifestations in vitiligo. J Indian Med Assoc 2003;101:478–480.
  • 4 Karadag R, Esmer O, Karadag AS, et al. Evaluation of ocular findings in patients with vitiligo. Int J Dermatol 2016;55:351–355.
  • 5 Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res. 2010;29:144–168.
  • 6 Ilhan N, Rifaioglu EN, Ilhan O, et al. Retinal Pigment Epithelium Thickness Analysis with Optical Coherence Tomography in Patients with Vitiligo. Med Sci 2015;31:587–591.
  • 7 Demirkan S, Onaran Z, Samav G et al. Decreased choroidal thickness in vitiligo patients. BMC Ophthalmol 2018;18:126.
  • 8 Wagoner MD, Albert DM, Lerner AB. Ocular abnormalities occuring with vitiligo. Ophthalmol 1978; 86:1145–1160.
  • 9 Nordlund JJ, Taylor NT, Albert DM, et al. The prevalence of vitiligo and poliosis in patients with uveitis. J Am Acad Dermatol 1981;4:528-536.
  • 10 Albert DM. Melanoma, vitiligo, and uveitis. Ophthalmology 2010;117:643-644.
  • 11 Aydin R, Ozsutcu M, Erdur SK, et al. The assessment of macular electrophysiology and macular morphology in patients with vitiligo. Int Ophthalmol 2018;38:233-239.
  • 12 Plonka PM, Passeron T, Brenner M, et al. What are melanocytes really doing all day long...? Exp Dermatol 2009;18:799-819.
  • 13 Cook CS, Ozanis V, Jakobiec FA. Prenatal development of the eye and its adnexa. In: Tasman W, editor. Duane’s Ophthalmology. Philadelphia: Lippincot-Raven Publishers, Inc, 1991:1–93.
  • 14 Mrejen S, Spaide RF. Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol 2013;58:387-429.
  • 15 Shibuya H, Watanabe R, MaenoA, et al. Melanocytes contribute to the vasculature of the choroid. Genes Genet Syst 2018;15;93:51-58.
  • 16 Adini I, Adini A, Bazinet L, et al. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB J 2015;29:662-670.
  • 17 Le Poole IC, Das PK, van den Wijngaard RM, et al. Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 1993;2:145–153.
  • 18 Sandoval-Cruz M, García-Carrasco M, Sánchez-Porras R, et al. Immunopathogenesis of vitiligo. Autoimmun Rev 2011;10:762–765. 19 Richmond JM, Frisoli ML, Harris JE. Innate immune mechanisms in vitiligo: danger from within. Curr Opin Immunol 2013;25:676–682.
  • 20 Whitton ME, Pinart M, Batchelor J, et al. Interventions for vitiligo. Cochrane Database Syst Rev 2010;1:CD003263.
  • 21 Örnek N, Onaran Z, Koçak M, et al. Retinal nerve fiber layer thickness in vitiligo patients. J Res Med Sci 2013;18:405-407.
  • 22 Öncül H, Ayhan E. Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients. J Cosmet Dermatol. 2020;00:1–6.
There are 21 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Göktuğ Demirci 0000-0002-5079-4713

Gülşen Tükenmez Demirci 0000-0002-9646-0719

Sevil Karaman Erdur 0000-0001-9829-7268

Cafer Tanrıverdi 0000-0003-2445-6339

Publication Date December 27, 2022
Acceptance Date December 23, 2022
Published in Issue Year 2022 Volume: 6 Issue: 3

Cite

Vancouver Demirci G, Tükenmez Demirci G, Karaman Erdur S, Tanrıverdi C. Do Choroidal Melanocytes Affect Choroidal Thickness in Patients with Newly Diagnosed Vitiligo?. Med J West Black Sea. 2022;6(3):404-9.

Medical Journal of Western Black Sea is a scientific publication of Zonguldak Bulent Ecevit University Faculty of Medicine.

This is a refereed journal, which aims at achieving free knowledge to the national and international organizations and individuals related to medical sciences in publishedand electronic forms.

This journal is published three annually in April, August and December.
The publication language of the journal is Turkish and English.