Case Report
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Aşırı Doz Siklopentolat Göz Damlasına Bağlı Gelişen Santral Antikolinerjik Sendrom

Year 2018, Volume: 25 Issue: 3, 333 - 335, 01.09.2018
https://doi.org/10.17343/sdutfd.365015

Abstract

Siklopentolat hidroklorür %1 damla göz
kliniklerinde çok sık kullanılan topikal midriyatik ve sikloplejik bir ilaçtır.
Bu olguda sekiz yaşındaki hastaya yanlışlıkla toplamda 16 damla siklopentolat
hidroklorür %1 döküldükten sonra gelişen santral antikolinerjik sendrom
sunulmuştur. Dizartri, ataksik yürüyüş, görsel halüsinasyon, ağız şapırdatma,
dizoryantasyon ve yüzde kızarıklık gelişen hasta, tıbbi gözetim altında
tutulmuş ve tüm bulgular 6 saat içinde spontan düzelmiştir. Özellikle uygun
dozda kullanılmayan siklopentolat göz damlasına bağlı sistemik yan etkiler
gelişebileceği için bu hastalar gözlem altında tutulmalıdır.

References

  • 1. Lovasik JV. Pharmacokinetics of topically applied cyclopentolate HCl and tropicamide. Am J Optom Physiol Opt 1986; 63:787–803
  • 2. Awan KJ. Adverse systemic reactions of topical cyclopentolate hydrochloride. Ann Ophthalmol 1976; 8: 695-698.
  • 3. Huismans H. Intoxikationspsychose nach Cyclopentolat-HCl (Zyklolat). Klin Monatsbl Augenheilkd 1979; 175: 100-102.
  • 4. Haaga M, Kaila T, Salminen L, Ylitalo P. Systemic and ocular absorption and antagonist activity of topically applied cyclopentolate in man. Pharmacol Toxicol. 1998 ;82(1):19-22.
  • 5. Gilman AG, Rall TW, Nies AS, Taylor P,eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 8th ed. New York, NY, Pergamon Press, 1990
  • 6. Simcoe CW. Cyclopentolate (Cyclogyl) toxicity. Report of a case. Arch Ophthalmol. 1962; 67:406-408
  • 7. Baysal Z, Cengiz M, Oğuz H, Ganidağlı S. Central Anticholinergic Syndrome Induced by Cyclopentolate Eye Drops in A 4 Year Old Child. The Internet Journal of Emergency and Intensive Care Medicine 2006:9(1).
  • 8. Bhatia SS, Vidyashankar C, Sharma RK, Dubey AK. Systemic toxicity with cyclopentolate eye drops. Indian Pediatr 2000;37:329-331.
  • 9. Ağın H, Gerçek H, Kutlu A, Gülez N, Atlıhan F. Topikal siklopentolat kullanımına bağlı gelişen deliryum tablosu: Bir vaka takdimi. Çocuk Sağlığı ve Hastalıkları Dergisi 2008; 51: 39-42
  • 10. BinkhorstRD,WeinsteinGW,BaretzRM,ClahaneAC. Psychotic reaction induced by cyclopentolate (cyclogyl); results of a pilot study and a double-blind study. Am J Ophthalmol 1963; 55:1243–1245
  • 11. Khurana AK, Ahluwalia BK, Rajan C, Vohra AK. Acute psychosis associated with topical cyclopentolate hydrochloride. Am J Ophthalmol. 1988; 15:105(1):91
  • 12. Bagheri A, Givrad S, Yazdani S, Reza Mohebbi M.Optimal dosage of cyclopentolate 1% for complete cycloplegia: a randomized clinical trial. Eur J Ophthalmol. 2007 ;17(3):294-300.
  • 13. Mirshahi A, Kohnen T. Acute psychotic reaction caused by topical cyclopentolate use for cycloplegic refraction before refractive surgery: case report and review of the literature. J Cataract Refract Surg. 2003 ;29(5):1026-1030.

Central Anticholinergic Syndrome Induced by Overdose Cyclopentolate Eye Drops

Year 2018, Volume: 25 Issue: 3, 333 - 335, 01.09.2018
https://doi.org/10.17343/sdutfd.365015

Abstract

Cyclopentolate hydrochloride %1 is a commonly used drug
as a topical mydriatic and cycloplegic agent in ophthalmology clinics. In this report, an eight years old
patient was presented who diagnosed as central anticholinergic syndrome after
accidental instillation of a total dose of 16 drops cyclopentolate
hydrochloride %1. Patient was strickly monitered as for the symptoms of dysarthria,
gait ataxia, visual hallucination, mouth sneezing, disorientation and facial redness.
All findings were resolved spontaneously within 6 hours. Cyclopentolate eye
drops can cause systemic side effects especially if not used at appropriate
dose, thus these patients should be observed.

References

  • 1. Lovasik JV. Pharmacokinetics of topically applied cyclopentolate HCl and tropicamide. Am J Optom Physiol Opt 1986; 63:787–803
  • 2. Awan KJ. Adverse systemic reactions of topical cyclopentolate hydrochloride. Ann Ophthalmol 1976; 8: 695-698.
  • 3. Huismans H. Intoxikationspsychose nach Cyclopentolat-HCl (Zyklolat). Klin Monatsbl Augenheilkd 1979; 175: 100-102.
  • 4. Haaga M, Kaila T, Salminen L, Ylitalo P. Systemic and ocular absorption and antagonist activity of topically applied cyclopentolate in man. Pharmacol Toxicol. 1998 ;82(1):19-22.
  • 5. Gilman AG, Rall TW, Nies AS, Taylor P,eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 8th ed. New York, NY, Pergamon Press, 1990
  • 6. Simcoe CW. Cyclopentolate (Cyclogyl) toxicity. Report of a case. Arch Ophthalmol. 1962; 67:406-408
  • 7. Baysal Z, Cengiz M, Oğuz H, Ganidağlı S. Central Anticholinergic Syndrome Induced by Cyclopentolate Eye Drops in A 4 Year Old Child. The Internet Journal of Emergency and Intensive Care Medicine 2006:9(1).
  • 8. Bhatia SS, Vidyashankar C, Sharma RK, Dubey AK. Systemic toxicity with cyclopentolate eye drops. Indian Pediatr 2000;37:329-331.
  • 9. Ağın H, Gerçek H, Kutlu A, Gülez N, Atlıhan F. Topikal siklopentolat kullanımına bağlı gelişen deliryum tablosu: Bir vaka takdimi. Çocuk Sağlığı ve Hastalıkları Dergisi 2008; 51: 39-42
  • 10. BinkhorstRD,WeinsteinGW,BaretzRM,ClahaneAC. Psychotic reaction induced by cyclopentolate (cyclogyl); results of a pilot study and a double-blind study. Am J Ophthalmol 1963; 55:1243–1245
  • 11. Khurana AK, Ahluwalia BK, Rajan C, Vohra AK. Acute psychosis associated with topical cyclopentolate hydrochloride. Am J Ophthalmol. 1988; 15:105(1):91
  • 12. Bagheri A, Givrad S, Yazdani S, Reza Mohebbi M.Optimal dosage of cyclopentolate 1% for complete cycloplegia: a randomized clinical trial. Eur J Ophthalmol. 2007 ;17(3):294-300.
  • 13. Mirshahi A, Kohnen T. Acute psychotic reaction caused by topical cyclopentolate use for cycloplegic refraction before refractive surgery: case report and review of the literature. J Cataract Refract Surg. 2003 ;29(5):1026-1030.
There are 13 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Case Reports
Authors

Mehmet Barış Üçer

Hülya Gökmen Soysal

Publication Date September 1, 2018
Submission Date December 12, 2017
Acceptance Date February 2, 2018
Published in Issue Year 2018 Volume: 25 Issue: 3

Cite

Vancouver Üçer MB, Gökmen Soysal H. Aşırı Doz Siklopentolat Göz Damlasına Bağlı Gelişen Santral Antikolinerjik Sendrom. Med J SDU. 2018;25(3):333-5.

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