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ACUTE APPENDICITIS OR NEGATIVE APPENDECTOMY? WHICH WAS REDUCED DURING THE COVID-19 PANDEMIC?

Year 2023, Volume: 30 Issue: 3, 492 - 498, 23.09.2023
https://doi.org/10.17343/sdutfd.1344052

Abstract

Objective
The restrictions and fear against the hospitals during
the pandemic has caused a reduction in the emergency
department admittance but it appears that patients
with various surgical conditions have admitted with an
advanced condition. The aim of the present study is to
evaluate and to compare disease severity at the time
of admittance and the negative appendectomy rates
among the patients who were operated for acute appendicitis
between the pandemic period and before
the pandemics.
Material and Method
The data of the 152 patients who were operated for
acute appendicitis during the first episode of restrictions
of the pandemics (03.12.2020-05.31.2020) and
1 year before the restrictions (03.12.2019-05.31.2019)
were retrospectively evaluated. The rates of appendectomy
and complicated appendicitis, appendiceal
diameter, inflammatory markers, diagnostic imaging
modalities and length of hospital stay were evaluated.
Results
The appendectomy rates were reduced in the pandemic
period by 41.6% compared to the previous period.
Leucocyste and neutrophile counts and appendiceal
diameter were significantly higher in the pandemic
period than the previous period (p=0.003, p=0.014,
p=0.013, respectively). No significant difference was
observed for length of hospital stay between the 2
periods. Although not statistically significant, CT was
more commonly performed (59.3% vs 73.3%) while
US was less commonly performed (40.7% vs. 26.7%)
in the pandemic period. The rates of non-complicated
appendicits and malignancy were not different between
the 2 periods (63.5% vs. 67.9% and 2.1% vs. 2.8%,
respectively). Although not statistically significant, the
rate of complicated appendicitis was increased (16.7%
vs. 23.2%) and the rate of negative appendicitis was
reduced (17.7% vs. 7.1%)
Conclusion
It is not possible to withdraw strong conclusions depending
on the current literature data regarding the
prepandemic and pandemic comparison of complicated
appendicitis and negative appendicitis. Pandemic
has caused a considerable impact on the appendicitis
severity at admission and management process.

Project Number

Proje kapsamında destek alınmamış bir çalışmadır

References

  • 1. World Health Organization. Listings of WHO’s response to COVID- 19 [Internet]. 2020. Available from: https://www. who. int/ news-room/detail/29-06-2020-covidtimeline.
  • 2. Burgard M, Cherbanyk F, Nassiopoulos K, Malekzadeh S, Pugin F, Egger B. An effect of the COVID-19 pandemic: Significantly more complicated appendicitis due to delayed presentation of patients! PLoS One. 2021;16(5):e0249171.
  • 3. Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nature Medicine. 2020;26(4):450-2.
  • 4. Romero J, Valencia S, Guerrero A. Acute Appendicitis During Coronavirus Disease 2019 (COVID-19): Changes in Clinical Presentation and CT Findings. J Am Coll Radiol. 2020;17(8):1011-3.
  • 5. Karaca AS, Ozmen MM, Uçar AD, Yasti A, Demirer S. General Surgery Operating Room Practice in Patients with COVID-19. Turk J Surg. 2020;36(1):i-v.
  • 6. Sungur Z, Ergil J, Karaaslan K, Tomak Y, Turgut N, Kurtipek Ö. Recommendation for Resuming Elective Surgery during the Normalising Period in COVID-19 Pandemic. Turk J Anaesthesiol Reanim. 2021;49(1):58-62.
  • 7. Anteby R, Zager Y, Barash Y, Nadler R, Cordoba M, Klang E, et al. The Impact of the Coronavirus Disease 2019 Outbreak on the Attendance of Patients with Surgical Complaints at a Tertiary Hospital Emergency Department. J Laparoendosc Adv Surg Tech A. 2020;30(9):1001-7.
  • 8. Velayos M, Muñoz-Serrano AJ, Estefanía-Fernández K, Sarmiento Caldas MC, Moratilla Lapeña L, López-Santamaría M, et al. Influence of the coronavirus 2 (SARS-Cov-2) pandemic on acute appendicitis. An Pediatr (Engl Ed). 2020;93(2):118-22.
  • 9. Santana R, Sousa JS, Soares P, Lopes S, Boto P, Rocha JV. The Demand for Hospital Emergency Services: Trends during the First Month of COVID-19 Response: Portuguese Journal of Public Health. 2020 Apr 17:1-7. doi: 10.1159/000507764.
  • 10. Göksoy B, Akça MT, Inanç Ö F. The impacts of the COVID-19 outbreak on emergency department visits of surgical patients. Ulus Travma Acil Cerrahi Derg. 2020;26(5):685-92.
  • 11. Kumaira Fonseca M, Trindade EN, Costa Filho OP, Nácul MP, Seabra AP. Impact of COVID-19 Outbreak on the Emergency Presentation of Acute Appendicitis. Am Surg. 2020;86(11):1508-12.
  • 12. Sartori A, Podda M, Botteri E, Passera R, Agresta F, Arezzo A. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study). Updates Surg. 2021;73(6):2205-13.
  • 13. Tankel J, Keinan A, Blich O, Koussa M, Helou B, Shay S, et al. The Decreasing Incidence of Acute Appendicitis During COVID-19: A Retrospective Multi-centre Study. World J Surg. 2020;44(8):2458-63.
  • 14. Park HC, Kim MJ, Lee BH. Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis. Br J Surg. 2017;104(13):1785-90.
  • 15. American Collage of Surgeons. COVID-19 Guidelines for Triage of Emergency General Surgery Patients. 2020. Available from: https://www.facs.org/covid-19/clinical-guidance/elective-case/ emergency-surgery.
  • 16. Royal Collage of Surgeons of England. Updated Intercollegiate General Surgery Guidance on COVID-19. 2020. Available from: https://www.rcseng.ac.uk/coronavirus/joint-guidance- for-surgeons-v2.
  • 17. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020;115(5):766-73.
  • 18. Temple CL, Huchcroft SA, Temple WJ. The natural history of appendicitis in adults. A prospective study. Ann Surg. 1995;221(3):278-81.
  • 19. Gao Z, Li M, Zhou H, Liang Y, Zheng C, Li S, et al. Complicated appendicitis are common during the epidemic period of 2019 novel coronavirus (2019-nCoV). Asian J Surg. 2020;43(10):1002-5.
  • 20. Orthopoulos G, Santone E, Izzo F, Tirabassi M, Pérez-Caraballo AM, Corriveau N, et al. Increasing incidence of complicated appendicitis during COVID-19 pandemic. Am J Surg. 2021;221(5):1056-60.
  • 21. Meriç S, Vartanoglu Aktokmakyan T, Tokocin M, Aktimur YE, Hacım NA, Gülcicek OB. Comparative analysis of the management of acute appendicitis between the normal period and COVID-19 pandemic. Ulus Travma Acil Cerrahi Derg. 2021;27(1):22-5.
  • 22. Şahin A TE. Covid-19 pandemisi daha komplike akut apandisit olgularına mı yol açtı? Turkish Journal of Clinics and Laboratory. 2022;13(2):227-31.
  • 23. Lewis FR, Holcroft JW, Boey J, Dunphy E. Appendicitis. A critical review of diagnosis and treatment in 1,000 cases. Arch Surg. 1975;110(5):677-84.
  • 24. Chooi WK, Brown JA, Zetler P, Wiseman S, Cooperberg P. Imaging of acute appendicitis and its impact on negative appendectomy and perforation rates: the St. Paul's experience. Can Assoc Radiol J. 2007;58(4):220-4.
  • 25. Başkent A, Alkan M, Başkent MF. The effect of COVID-19 pandemic period on acute appendicitis and its complications. Ulus Travma Acil Cerrahi Derg. 2022;29(1):40-5.
  • 26. Ceresoli M, Coccolini F, Magnone S, Lucianetti A, Bisagni P, Armao T, et al. The decrease of non-complicated acute appendicitis and the negative appendectomy rate during pandemic. Eur J Trauma Emerg Surg. 2021;47(5):1359-65.

COVİD-19 PANDEMİ DÖNEMİNDE AKUT APANDİSİT Mİ, NEGATİF APENDEKTOMİ Mİ AZALDI?

Year 2023, Volume: 30 Issue: 3, 492 - 498, 23.09.2023
https://doi.org/10.17343/sdutfd.1344052

Abstract

Amaç
Pandemi döneminde hastanelerden duyulan korku ve
kısıtlamalar acil serviste hasta başvurularını önemli ölçüde
azaltırken çeşitli cerrahi hastalıkların ciddiyetinde
kayda değer bir artışına neden olmuştur. Çalışmamızda
ameliyat edilen akut apandisit olgularının başvuru
anındaki hastalık ciddiyetini ve negatif apendektomi
oranlarını belirleyerek bu sonuçları pandemi olmayan
dönemle karşılaştırmayı amaçladık.
Gereç ve Yöntem
Pandemi döneminde (12.03.2020- 31.05.2020) ve
pandemi olmayan dönemde (12.03.2019-31.05.2019)
apandisit nedeniyle tedavi edilen 152 hastanın verileri
geriye dönük olarak incelendi. Apendektomi sayıları,
komplike akut apandisit oranları, apandiks çapları, inflamatuar
belirteçler, tanısal amaçla tercih edilen görüntüleme
yöntemleri ve hastaların hastanede yatış
süreleri ile ilgili veriler analiz edildi.
Bulgular
Pandemi döneminde bir önceki yılın aynı zaman aralığına
kıyasla apendektomi sayısının %41,6 oranında
azaldığı tespit edildi. Pandemi döneminde lökosit ve
nötrofil sayısı ve apendiks çapının pandemi olmayan
döneme göre anlamlı oranda arttığı izlendi (sırasıyla
p=0.003,p=0.014,p=0,013). Her iki dönemde hastanede
yatış süreleri açısından anlamlı farklılık izlenmedi.
Pandemi döneminde anlamlı oranda olmasada bilgisayarlı
tomografi kullanımının arttığı (%59,3’e karşı
%73,3) ve USG kullanımının azaldığı (%40,7’ye karşı
%26,7) tespit edildi. Komplike olmayan akut apandisit
ve malignite oranlarının her iki dönemde benzer olduğu
izlendi (sırasıyla %63,5, %67,9 ve %2,1, %1,8).
Pandemi döneminde anlamlı oranda olmamakla birlikte
komplike apandisit oranının arttığı (%16,7’ye karşı
%23,2) ve negatif apendektomi oranının azaldığı
(%17,7’ye karşı %7,1) izlendi.
Sonuç
Pandemi öncesi dönemle kıyaslandığında komplike
apandisit ve negatif apendektomi oranlarında tespit
ettiğimiz ancak istatistiksel olmayan farkla ilgili mevcut
literatürden kesin hüküm çıkarmak mümkün değildir.
Pandemi apandisitin tanı zamanının yanı sıra seyrini
ve tedavi yaklaşımını de etkilemiştir.

Supporting Institution

herhangi bir mali destek alınmamıştır

Project Number

Proje kapsamında destek alınmamış bir çalışmadır

Thanks

Zaman ayırdığınız ve değerlendirdiğiniz için teşekkür ediyorum

References

  • 1. World Health Organization. Listings of WHO’s response to COVID- 19 [Internet]. 2020. Available from: https://www. who. int/ news-room/detail/29-06-2020-covidtimeline.
  • 2. Burgard M, Cherbanyk F, Nassiopoulos K, Malekzadeh S, Pugin F, Egger B. An effect of the COVID-19 pandemic: Significantly more complicated appendicitis due to delayed presentation of patients! PLoS One. 2021;16(5):e0249171.
  • 3. Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nature Medicine. 2020;26(4):450-2.
  • 4. Romero J, Valencia S, Guerrero A. Acute Appendicitis During Coronavirus Disease 2019 (COVID-19): Changes in Clinical Presentation and CT Findings. J Am Coll Radiol. 2020;17(8):1011-3.
  • 5. Karaca AS, Ozmen MM, Uçar AD, Yasti A, Demirer S. General Surgery Operating Room Practice in Patients with COVID-19. Turk J Surg. 2020;36(1):i-v.
  • 6. Sungur Z, Ergil J, Karaaslan K, Tomak Y, Turgut N, Kurtipek Ö. Recommendation for Resuming Elective Surgery during the Normalising Period in COVID-19 Pandemic. Turk J Anaesthesiol Reanim. 2021;49(1):58-62.
  • 7. Anteby R, Zager Y, Barash Y, Nadler R, Cordoba M, Klang E, et al. The Impact of the Coronavirus Disease 2019 Outbreak on the Attendance of Patients with Surgical Complaints at a Tertiary Hospital Emergency Department. J Laparoendosc Adv Surg Tech A. 2020;30(9):1001-7.
  • 8. Velayos M, Muñoz-Serrano AJ, Estefanía-Fernández K, Sarmiento Caldas MC, Moratilla Lapeña L, López-Santamaría M, et al. Influence of the coronavirus 2 (SARS-Cov-2) pandemic on acute appendicitis. An Pediatr (Engl Ed). 2020;93(2):118-22.
  • 9. Santana R, Sousa JS, Soares P, Lopes S, Boto P, Rocha JV. The Demand for Hospital Emergency Services: Trends during the First Month of COVID-19 Response: Portuguese Journal of Public Health. 2020 Apr 17:1-7. doi: 10.1159/000507764.
  • 10. Göksoy B, Akça MT, Inanç Ö F. The impacts of the COVID-19 outbreak on emergency department visits of surgical patients. Ulus Travma Acil Cerrahi Derg. 2020;26(5):685-92.
  • 11. Kumaira Fonseca M, Trindade EN, Costa Filho OP, Nácul MP, Seabra AP. Impact of COVID-19 Outbreak on the Emergency Presentation of Acute Appendicitis. Am Surg. 2020;86(11):1508-12.
  • 12. Sartori A, Podda M, Botteri E, Passera R, Agresta F, Arezzo A. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study). Updates Surg. 2021;73(6):2205-13.
  • 13. Tankel J, Keinan A, Blich O, Koussa M, Helou B, Shay S, et al. The Decreasing Incidence of Acute Appendicitis During COVID-19: A Retrospective Multi-centre Study. World J Surg. 2020;44(8):2458-63.
  • 14. Park HC, Kim MJ, Lee BH. Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis. Br J Surg. 2017;104(13):1785-90.
  • 15. American Collage of Surgeons. COVID-19 Guidelines for Triage of Emergency General Surgery Patients. 2020. Available from: https://www.facs.org/covid-19/clinical-guidance/elective-case/ emergency-surgery.
  • 16. Royal Collage of Surgeons of England. Updated Intercollegiate General Surgery Guidance on COVID-19. 2020. Available from: https://www.rcseng.ac.uk/coronavirus/joint-guidance- for-surgeons-v2.
  • 17. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020;115(5):766-73.
  • 18. Temple CL, Huchcroft SA, Temple WJ. The natural history of appendicitis in adults. A prospective study. Ann Surg. 1995;221(3):278-81.
  • 19. Gao Z, Li M, Zhou H, Liang Y, Zheng C, Li S, et al. Complicated appendicitis are common during the epidemic period of 2019 novel coronavirus (2019-nCoV). Asian J Surg. 2020;43(10):1002-5.
  • 20. Orthopoulos G, Santone E, Izzo F, Tirabassi M, Pérez-Caraballo AM, Corriveau N, et al. Increasing incidence of complicated appendicitis during COVID-19 pandemic. Am J Surg. 2021;221(5):1056-60.
  • 21. Meriç S, Vartanoglu Aktokmakyan T, Tokocin M, Aktimur YE, Hacım NA, Gülcicek OB. Comparative analysis of the management of acute appendicitis between the normal period and COVID-19 pandemic. Ulus Travma Acil Cerrahi Derg. 2021;27(1):22-5.
  • 22. Şahin A TE. Covid-19 pandemisi daha komplike akut apandisit olgularına mı yol açtı? Turkish Journal of Clinics and Laboratory. 2022;13(2):227-31.
  • 23. Lewis FR, Holcroft JW, Boey J, Dunphy E. Appendicitis. A critical review of diagnosis and treatment in 1,000 cases. Arch Surg. 1975;110(5):677-84.
  • 24. Chooi WK, Brown JA, Zetler P, Wiseman S, Cooperberg P. Imaging of acute appendicitis and its impact on negative appendectomy and perforation rates: the St. Paul's experience. Can Assoc Radiol J. 2007;58(4):220-4.
  • 25. Başkent A, Alkan M, Başkent MF. The effect of COVID-19 pandemic period on acute appendicitis and its complications. Ulus Travma Acil Cerrahi Derg. 2022;29(1):40-5.
  • 26. Ceresoli M, Coccolini F, Magnone S, Lucianetti A, Bisagni P, Armao T, et al. The decrease of non-complicated acute appendicitis and the negative appendectomy rate during pandemic. Eur J Trauma Emerg Surg. 2021;47(5):1359-65.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects General Surgery
Journal Section Research Articles
Authors

Metin Yalaza 0000-0001-7104-7103

Betül Keskinkılıç Yağız 0000-0003-2271-2116

Serdar Coşkun 0000-0002-7238-6032

Project Number Proje kapsamında destek alınmamış bir çalışmadır
Publication Date September 23, 2023
Submission Date August 15, 2023
Acceptance Date August 28, 2023
Published in Issue Year 2023 Volume: 30 Issue: 3

Cite

Vancouver Yalaza M, Keskinkılıç Yağız B, Coşkun S. COVİD-19 PANDEMİ DÖNEMİNDE AKUT APANDİSİT Mİ, NEGATİF APENDEKTOMİ Mİ AZALDI?. Med J SDU. 2023;30(3):492-8.

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