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Rejeneratif Endodontik Tedavi: Bir Literatür Derlemesi

Year 2022, Volume: 9 Issue: 1, 335 - 343, 27.04.2022
https://doi.org/10.15311/selcukdentj.1096961

Abstract

ÖZ: Travma, dental anomaliler, çürük gibi nedenlerle dişler kök oluşumunu tamamlayamadan nekroz olabilirler. Açık apeksli dişlerde endodontik tedaviler birtakım zorluklar barındırmaktadır. Kök duvarlarının kırılgan olması, apeksin açık olması endodontik tedaviyi zorlaştıran sebeplerdendir. Rejeneratif endodontik tedavi nekroz olmuş açık apeksli dişlerde semptomların ortadan kalkmasını, kök gelişiminin devam etmesini, dişlerin vitalite kazanmasını sağlayabilen biyolojik temelli endodontik tedavi seçeneğidir. Rejeneratif endodontik tedavide kök kanalları dezenfekte edildikten sonra kanal içerisinde biyolojik bir iskele oluşturulması sağlanır. Bu iskele büyüme faktörleri ve kök hücrelerin de yardımıyla rejeneratif bir pulpa dokusu oluşturmak için destek görevi görür. Organize pulpa dokusu oluşturulması hedeflense de yapılan araştırmalarda gerçek pulpa dokusu oluşumu kanıtlanmamıştır. Günümüzde bu tedavi immatür nekrotik dişlerin endodontik tedavisinde ilk seçenek olarak önerilmektedir. Bu tedavinin diş sağkalımı üzerinde yüksek başarı oranlarına sahip olduğu birçok çalışmada gösterilmiştir. Bu makalede rejeneratif endodontik tedavi ve bu tedavinin olumlu-olumsuz sonuçlarının güncel literatürdeki yeri derlenmiştir.

ABSTRACT: Due to trauma, dental anomalies, caries, etc., the teeth may become necrosis before they can complete their root formation. Endodontic treatments in open apex teeth present some difficulties. The fragility of the root walls and the open apex are among the reasons that complicate the endodontic treatment. Regenerative endodontic treatment is a biological-based endodontic treatment option that can provide relief of symptoms, continuation of root development, and vitality of teeth in necrotic, open apex teeth. In regenerative endodontic treatment, after the root canals are disinfected, a biological scaffold is formed within the canal. This scaffold acts as a support to form a regenerative pulp tissue with the help of growth factors and stem cells. Although it is aimed to create organized pulp tissue, true pulp tissue formation has not been proven in the studies. Today, this treatment is recommended as the first choice in the endodontic treatment of immature necrotic teeth. Many studies have shown that this treatment has high success rates on dental survival. In this article, regenerative endodontic treatment and its positive and negative results in the current literature are reviewed.

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Year 2022, Volume: 9 Issue: 1, 335 - 343, 27.04.2022
https://doi.org/10.15311/selcukdentj.1096961

Abstract

References

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  • 6. Nicoloso GF, Goldenfum GM, Pizzol TdSD, Scarparo RK, Montagner F, de Almeida Rodrigues J, et al. Pulp revascularization or apexification for the treatment of immature necrotic permanent teeth: systematic review and meta-analysis. Int J Clin Pediatr Dent. 2019;43(5):305-13.
  • 7. Iwaya Si, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol. 2001;17(4):185-7.
  • 8. Huang GT-J, Lin LM. Comments on the use of the term “revascularization” to describe. J Endod. 2008;34(5):511.
  • 9. Galler K, Krastl G, Simon S, Van Gorp G, Meschi N, Vahedi B, et al. European Society of Endodontology position statement: revitalization procedures. Int Endod J. 2016;49(8):717-23.
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  • 11. Östby BN. The role of the blood clot in endodontic therapy an experimental histologic study. Acta Odontol Scand. 1961;19(3-4):323-53.
  • 12. Nygaard‐Östby B, Hjortdal O. Tissue formation in the root canal following pulp removal. Eur J Oral Sci. 1971;79(3):333-49.
  • 13. Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? J Endod. 2004;30(4):196-200.
  • 14. Lin LM, Kahler B. A review of regenerative endodontics: current protocols and future directions. J Istanb Univ Fac Dent. 2017;51(3 Suppl 1):S41.
  • 15. Kim SG. Infection and pulp regeneration. Dent J (Basel). 2016;4(1):4.
  • 16. Fouad AF. Microbial factors and antimicrobial strategies in dental pulp regeneration. J Endod. 2017;43(9):S46-S50.
  • 17. Mohammadi Z. Sodium hypochlorite in endodontics: an update review. Int Dent J. 2008;58(6):329-41.
  • 18. Sena N, Gomes B, Vianna M, Berber V, Zaia A, Ferraz C, et al. In vitro antimicrobial activity of sodium hypochlorite and chlorhexidine against selected single‐species biofilms. Int Endod J. 2006;39(11):878-85.
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  • 20. Kontakiotis EG, Filippatos CG, Tzanetakis GN, Agrafioti A. Regenerative endodontic therapy: a data analysis of clinical protocols. J Endod. 2015;41(2):146-54.
  • 21. Martin DE, De Almeida JFA, Henry MA, Khaing ZZ, Schmidt CE, Teixeira FB, et al. Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation. J Endod. 2014;40(1):51-5.
  • 22. Galler KM, Buchalla W, Hiller K-A, Federlin M, Eidt A, Schiefersteiner M, et al. Influence of root canal disinfectants on growth factor release from dentin. J Endod. 2015;41(3):363-8.
  • 23. Mohammadi Z, Shalavi S, Jafarzadeh H. Ethylenediaminetetraacetic acid in endodontics. Eur J Dent. 2013;7(S 01):S135-S42.
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There are 105 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Review
Authors

Enes Mustafa Aşar 0000-0003-3432-8584

Murat Selim Botsalı 0000-0002-5719-5430

Publication Date April 27, 2022
Submission Date April 1, 2022
Published in Issue Year 2022 Volume: 9 Issue: 1

Cite

Vancouver Aşar EM, Botsalı MS. Rejeneratif Endodontik Tedavi: Bir Literatür Derlemesi. Selcuk Dent J. 2022;9(1):335-43.