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YAŞLILARDA PROTON POMPA İNHİBİTÖRÜ KULLANIMI VE RENAL FONKSİYONLARLA İLİŞKİSİ

Year 2020, Volume: 14 Issue: 3, 403 - 406, 20.09.2020
https://doi.org/10.21763/tjfmpc.698985

Abstract

Amaç: Son dönemlerde proton pompa inhibitörlerinin yan etkilerinden ve özellikle de renal etkilerinden daha sık söz edilmektedir. Akut tübülointerstisyel nefrit, akut böbrek hasarı, kronik böbrek hasarının progresyonu gibi klinik durumlara neden olabileceği düşünülmektedir. Biz bu çalışmamızda nefroloji polikliniğimize başvuran yaşlı hastalarda proton pompa inhibitörü kullanım sıklığını, proteinüri ve böbrek hasarıyla olan ilişkisini inceledik. Yöntem: Bir yıllık sürede nefroloji polikliniğine başvuran 75 yaş ve üzerindeki hastaların dosyaları incelenmiştir. Bulgular: 75 yaş ve üzeri nefroloji polikliniğine başvuran hastalarımızda proton pompa inhibitörü kullanma sıklığı yüksektir. Proton pompa inhibitörü kullanan yaşlı hastalarda kronik böbrek hasarı birlikteliği istatistiksel olarak anlamlı olmasa da daha sık bulunmuştur. Tartışma: Proton pompa inhibitörlerinin bilinçsiz ve/veya endikasyon dışı kullanımı renal fonksiyonlarda bozulmayla ilişkili olabilir. Proton pompa inhibitörü kullanmak zorunda olan hastalarda renal fonksiyonlar takip edilmelidir.

References

  • 1. Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013; 382: 260–272.
  • 2. Ruffenach SJ, Siskind MS, Lien YH. Acute interstitial nephritis due to omeprazole. Am J Med. 1992; 93: 472-473.
  • 3. Simpson IJMM, Pilmore H, Manley P, Williams L, Thein H, Voss D. Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases. Nephrology 2006; 11: 381-385.
  • 4. Geevasinga N, Coleman PL,Webster AC, Roger SD. Proton pump inhibitors and acute interstitial nephritis. Clin Gastroenterol Hepatol. 2006; 4: 597-604.
  • 5. Sierra F, Suarez M, Rey M et al. Systematic review: proton pump inhibitör associated acute interstitial nephritis. Aliment Pharmacol Ther 2007; 26: 545–553.
  • 6. Praga M, Gonzalez E. Acute interstitial nephritis. Kidney Int 2010; 77: 956–961.
  • 7. Shih-Chang Hunga, Kuan-Fu Liaob, Hung-Chang Hunge, Cheng-Li Ling, Shih-Wei Laig, Po-Chang Leej, Shih-Rong Hung. Using proton pump inhibitors correlates with an increased risk of chronic kidney disease: a nationwide database-derived case controlled study. Family Practice, 2018; 35: 166–171. 8. Antoniou T, Macdonald EM, Hollands S et al. Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. CMAJ Open 2015; 3: E166–71.
  • 9. Klatte DCF, Gasparini A, Xu H, de Deco P, Trevisan M, Johansson ALV, Wettermark B, Ärnlöv J, Janmaat CJ, Lindholm B, Dekker FW, Coresh J, Grams ME, Carrero JJ. Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease. Gastroenterology. 2017;153: 702-710.
  • 10. Karn Wijarnpreecha, Charat Thongprayoon, Supavit Chesdachai, Panadeekarn Panjawatanana, Patompong Ungprasert, Wisit Cheungpasitporn. Associations of Proton-Pump Inhibitors and H2 Receptor Antagonists with Chronic Kidney Disease: A Meta-Analysis. Dig Dis Sci. 2017; 62: 2821–2827.
  • 11. Uludag O, Mirioglu S, Dirim A, Akardere O, Akyildiz A, Sever M, Caliskan Y. Effects of proton pump inhibitors on kidney transplant recipients. Nephrol Dial Transplant 2017; 32 suppl 3: iii730.
  • 12. Rodriguez-Poncelas A, Barcelo MA, Saez M, Coll-de-Tuero G. Duration and dosing of proton pump inhibitors associated with high incidence of chronic kidney disease in population-based cohort. PloS One. 2018; 13: e0204231.
  • 13. Xie Y, Bowe B, Li T, Xian H, Yan Y, Al-Aly Z. Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury. Kidney Int. 2017; 91: 1482-1494.
  • 14. Forgacs I, Loganayagam A. Overprescribing proton pump inhibitors. BMJ. 2008; 336: 2-3.
  • 15. Strid H, Simren M, Bjornsson ES. Overuse of acid suppressant drugs in patients with chronic renal failure. Nephrol Dial Transplant. 2003; 18: 570-575.
  • 16. Lee HJ, Lee H, Oh SH, et al. Chronic kidney disease (CKD) patients are exposed to more proton pump inhibitor (PPI)s compared to non-CKD patients. PloS One. 2018; 13: e0203878.
  • 17. Blank ML, Parkin L, Paul C, Herbison P. A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use. Kidney Int. 2014; 86(4): 837–844.
  • 18. Farrell B, Pottie K, Thompson W, et al. Deprescribing proton pump inhibitors: evidence-based clinical practice guideline. Can Fam Physician. 2017; 63: 354-36

ASSOCIATION OF PROTON PUMP INHIBITORS USE AND RENAL FUNCTIONS IN ELDERLY

Year 2020, Volume: 14 Issue: 3, 403 - 406, 20.09.2020
https://doi.org/10.21763/tjfmpc.698985

Abstract

Introduction: Recently, side effects and especially renal effects of proton pump inhibitors have been pronounced more frequently. It is thought that they may lead to clinical situations as acute tubulointerstitial nephritis, acute kidney injury and progression of chronic kidney injury. In this study, we investigated the frequency of proton pump inhibitor use and its association with proteinuria and kidney injury in older patients admitted to our nephrology outpatient clinic. Methods: The medical records of patients aged 75 years and older who applied to the nephrology outpatient clinic for a period of one year were examined. Results: The frequency of proton pump inhibitors use is high in our 75 years and older patients admitted to the nephrology outpatient clinic. In elderly patients using proton pump inhibitors, the association with chronic kidney injury was found to be more frequent, although not statistically significant. Conclusion: Unaware and/or off-label use of proton pump inhibitors may be associated with impaired renal function. Renal functions should be monitored in patients who have to use a proton pump inhibitor.

References

  • 1. Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013; 382: 260–272.
  • 2. Ruffenach SJ, Siskind MS, Lien YH. Acute interstitial nephritis due to omeprazole. Am J Med. 1992; 93: 472-473.
  • 3. Simpson IJMM, Pilmore H, Manley P, Williams L, Thein H, Voss D. Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases. Nephrology 2006; 11: 381-385.
  • 4. Geevasinga N, Coleman PL,Webster AC, Roger SD. Proton pump inhibitors and acute interstitial nephritis. Clin Gastroenterol Hepatol. 2006; 4: 597-604.
  • 5. Sierra F, Suarez M, Rey M et al. Systematic review: proton pump inhibitör associated acute interstitial nephritis. Aliment Pharmacol Ther 2007; 26: 545–553.
  • 6. Praga M, Gonzalez E. Acute interstitial nephritis. Kidney Int 2010; 77: 956–961.
  • 7. Shih-Chang Hunga, Kuan-Fu Liaob, Hung-Chang Hunge, Cheng-Li Ling, Shih-Wei Laig, Po-Chang Leej, Shih-Rong Hung. Using proton pump inhibitors correlates with an increased risk of chronic kidney disease: a nationwide database-derived case controlled study. Family Practice, 2018; 35: 166–171. 8. Antoniou T, Macdonald EM, Hollands S et al. Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. CMAJ Open 2015; 3: E166–71.
  • 9. Klatte DCF, Gasparini A, Xu H, de Deco P, Trevisan M, Johansson ALV, Wettermark B, Ärnlöv J, Janmaat CJ, Lindholm B, Dekker FW, Coresh J, Grams ME, Carrero JJ. Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease. Gastroenterology. 2017;153: 702-710.
  • 10. Karn Wijarnpreecha, Charat Thongprayoon, Supavit Chesdachai, Panadeekarn Panjawatanana, Patompong Ungprasert, Wisit Cheungpasitporn. Associations of Proton-Pump Inhibitors and H2 Receptor Antagonists with Chronic Kidney Disease: A Meta-Analysis. Dig Dis Sci. 2017; 62: 2821–2827.
  • 11. Uludag O, Mirioglu S, Dirim A, Akardere O, Akyildiz A, Sever M, Caliskan Y. Effects of proton pump inhibitors on kidney transplant recipients. Nephrol Dial Transplant 2017; 32 suppl 3: iii730.
  • 12. Rodriguez-Poncelas A, Barcelo MA, Saez M, Coll-de-Tuero G. Duration and dosing of proton pump inhibitors associated with high incidence of chronic kidney disease in population-based cohort. PloS One. 2018; 13: e0204231.
  • 13. Xie Y, Bowe B, Li T, Xian H, Yan Y, Al-Aly Z. Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury. Kidney Int. 2017; 91: 1482-1494.
  • 14. Forgacs I, Loganayagam A. Overprescribing proton pump inhibitors. BMJ. 2008; 336: 2-3.
  • 15. Strid H, Simren M, Bjornsson ES. Overuse of acid suppressant drugs in patients with chronic renal failure. Nephrol Dial Transplant. 2003; 18: 570-575.
  • 16. Lee HJ, Lee H, Oh SH, et al. Chronic kidney disease (CKD) patients are exposed to more proton pump inhibitor (PPI)s compared to non-CKD patients. PloS One. 2018; 13: e0203878.
  • 17. Blank ML, Parkin L, Paul C, Herbison P. A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use. Kidney Int. 2014; 86(4): 837–844.
  • 18. Farrell B, Pottie K, Thompson W, et al. Deprescribing proton pump inhibitors: evidence-based clinical practice guideline. Can Fam Physician. 2017; 63: 354-36
There are 17 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section Orijinal Articles
Authors

Alper Alp 0000-0002-2864-361X

Sibel Ersan 0000-0002-9381-5262

Publication Date September 20, 2020
Submission Date March 5, 2020
Published in Issue Year 2020 Volume: 14 Issue: 3

Cite

Vancouver Alp A, Ersan S. YAŞLILARDA PROTON POMPA İNHİBİTÖRÜ KULLANIMI VE RENAL FONKSİYONLARLA İLİŞKİSİ. TJFMPC. 2020;14(3):403-6.

English or Turkish manuscripts from authors with new knowledge to contribute to understanding and improving health and primary care are welcome.