Lhermitte-Duclos Disease Recovery After Subtotal Resection; Case Report

Year 2025, Volume: 10 Issue: 2, 81 - 86, 28.05.2025

Oğuzhan Uzlu , Durmuş Oğuz Karakoyun , Ömer Faruk Şahin , Mağruf İlkay Yapakcı

https://doi.org/10.70852/tmj.1581633

Abstract

Lhermitte-Duclos Disease (LDD) is a rare benign hamartomatous disorder that typically manifests unilaterally in the cerebellum, leading to thickening of the molecular and granular cell layers of the cerebellar cortex. It most commonly occurs in young adulthood, typically in the third or fourth decade of life. Since LDD is a slowly progressive disease, conservative management is an option in the absence of mass effect, whereas total excision is recommended in symptomatic patients. In our case, subtotal resection was performed due to indistinct surgical margins observed intraoperatively. Postoperative cranial magnetic resonance imaging (MRI) demonstrated regression of the lesion. No recurrence or residual tumor was detected at the 7-month follow-up. During this period, the patient remained neurologically stable without newly developed symptoms or deficits. However, long-term follow-up is essential to monitor for potential recurrence.

Keywords

Cerebellum, Lhermitte Duclos, Subtotal Resection

Lhermitte-Duclos Hastalığının Subtotal Rezeksiyondan Sonra İyileşmesi; Vaka Raporu

Abstract

Lhermitte-Duclos Hastalığı (LDH) genç erişkinlikte, genellikle 3-4. dekatta çok nadir görülen tipik olarak serebellumu tek taraflı tutan, serebellar korteksin moleküler ve granüler hücre katmanlarında kalınlaşma gösteren iyi huylu hamartomatöz bir hastalıktır. LDH yavaş ilerleyen bir hastalık olduğundan kitleye ait bulgu yoksa konservatif olarak tedavi edilebilirken, kitle etkisi olan hastalarda total eksizyon önerilmesine rağmen olgumuzda ameliyat sırasında bu ayrım net olarak yapılamadığı için subtotal rezeksiyon yapıldı. Postoperatif kontrolünde kraniyal manyetik rezonans (MRG) incelemesinde lezyonun gerilediği görüldü. Hastanın postoperatif 7. ay kontrollerinde nüks veya rezidü izlenmedi. Hastanın 7 aylık takibinde yeni gelişen nörolojik semptom veya defisit yoktu. Ancak uzun dönem takiplerde nüks açısından hastalar yakın takip edilmelidir.

Keywords

Lhermitte Duclos, Serebellum, Subtotal Rezeksiyon

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