Research Article
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Feline Vaccine-Associated Sarcomas: Surgical Results in 18 Cats

Year 2019, Volume: 90 Issue: 1, 22 - 29, 15.01.2019
https://doi.org/10.33188/vetheder.483641

Abstract










The
purpose of this study is to report the diagnosis and surgical outcomes of
vaccine-related sarcomas that are formed after injection in cats. In this study
18 cats in different gender, age and weights were evaluated by the complaint of
post-injection mass formation. It was found that masses were often formed in
interscapular (n:7), lumbar (n:5) regions of body that is preferred generally
for subcutaneous injection applications. Masses were removed surgically with a
wide incision as possible. Histopathological examinations revealed fibrosarcoma
(n: 12), fibroosteocondrosarcoma (n:4), fibromyxosarcoma (n:2).
Intraoperativly, deep muscle tissue and surrounding tissue infiltration was
detected in 13 cases. After 3 months to 1 year of the surgery, 14 cases
recurrenced. It was obtained that in all of the recurrent cases, the mass
formed again in the previous operation line and did not metastasize to the
distant tissues.
   

References

  • Bregazzi VS, LaRue SM, McNiel E, McNiel E, Macy DW, Dernell WS, Powers BE, Withrow SJ (2001): Treatment with a combination of doxorubicin, surgery, and radiation versus surgery and radiation alone for cats with vaccine-associated sarcomas: 25 cases (1995–2000). J Am Vet Med Assoc, 218, 547-550.
  • Carminato A, Vascellari M, Marchioro W, Melchiotti E, Mutinelli F (2011): Microchip-associated fibrosarcoma in a cat. Vet Dermatol, 22, 565-569.
  • Cora R, Gal Af, Taulescu M, Tăbăran F, Vidrighinescu R, Cătoı C (2017): Description of a feline injection-site fibrosarcoma with metastasis in the cerebellum. Acta Vet Hung, 67, 578-586.
  • Couto SS, Griffey SM, Duarte PC, Madewell BR, 2002: Feline vaccine-associated fibrosarcoma: morphologic distinctions. Vet Pathol., 39, 33-41.
  • Davidson EB, Gregory CR, Kass PH (1997): Surgical excision of soft tissue fibrosarcomas in cats. Vet Surg, 26, 265-9.
  • Eckstein C, Guscetti F, Roos M, Martín de las Mulas J, Kaser-Hotz B, Rohrer Bley C (2009): A retrospective analysis of radiation therapy for the treatment of feline vaccine-associated sarcoma. Vet Comp Oncol, 7, 54-68.
  • Ferrari R, Di Giancamillo M, Stefanello D, Giudice C, Grieco V, Longo M, Ravasio G, Boracchi P (2017): Clinical and computed tomography tumour dimension assessments for planning wide excision of injection site sarcomas in cats: how strong is the agreement? Vet Comp Oncol, 15, 374-382.
  • Hahn KA, Endicott MM, King GK (2007): Evauation of radiotherapy alone or in combination with doxorubicin chemotherapy for the treatment of cats with incompletely excised soft tissue sarcomas: 71 cases (1989–1999). J Am Vet Med Assoc, 231,742-745.
  • Hartmann K, Day MJ, Thiry E, Lloret A, Frymus T, Addie D, Boucraut-Baralon C, Egberink H, Gruffydd-Jones T, Horzinek MC, Hosie MJ, Lutz H, Marsilio F, Pennisi MG, Radford AD, Truyen U, Möstl K (2015): European Advisory Board on Cat Diseases. Feline injection-site sarcoma: ABCD guidelines on prevention and management. J Feline Med Surg, 17, 606-13.
  • Hendrick MJ, Brooks JJ (1994): Postvaccinal sarcomas in the cat: histology and immunohistochemistry. Vet Pathol, 31, 126-129.
  • Hendrick MJ (2016): Mesenchymal Tumors of the Skin and Soft Tissues. In “Tumors in Domestic Animals”, Ed; Meuten DJ, Iowa State Press, IA.
  • Hill J, Lawrence J, Saba C, Turek M, Feldhaeusser B, Coutermarsh-Ott S, Barber J, Smith J, Gogal RJ (2014): In vitro efficacy of doxorubicin and etoposide against a feline injection site sarcoma cell line. Res Vet Sci, 97, 348-56.
  • Holtermann N, Kiupel M, Hirschberger J (2017): The tyrosine kinase inhibitor toceranib in feline injection site sarcoma: efficacy and side effects. Vet Comp Oncol, 15, 632-640.
  • Kass, P.H., Spangler, W.L., Hendrick, M.J., McGill, L.D., Esplin, D.G., Lester, S., Slater, M., Meyer, E.K., Boucher, F., Peters, E.M., Gobar, G.G., Htoo, T. (2003): Multicenter case-control study of risk factors associated with development of vaccineassociated sarcomas in cats. Journal of the American Veterinary Medical Association, 223, 1283-1292.
  • Longo M, Zani DD, Ferrari R, Bassi J, Andreis M, Stefanello D, Giudice C, Grieco V, Liuti T, Handel I, Di Giancamillo M. (2018): Dynamic tomographic studies of interscapular feline injection-site sarcoma: essential or useless practice? J Feline Med Surg, 20, 502-508.
  • Luna, LE (1968): Manual of Histological Staining Methods of the Armed Forces Institute of Pathology. McGraw-Hill, New York.
  • Martano M, Morello E and Buracco P. (2011): Feline injection-site sarcoma: past, present and future perspectives. The Veterinary Journal, 188, 136-141.
  • Martano M, Morello E, Iussich S, Buracco P. (2012): A case of feline injection-site sarcoma at the site of cisplatin injections. J Feline Med Surg, 14, 751-754.
  • McEntee MC, Page RL (2001): Feline vaccine-associated sarcomas. Journal of Veterinary Internal Medicine, 15, 176-182.
  • Müller N, Kessler M (2018): Curative-intent radical en bloc resection using a minimum of a 3 cm margin in feline injection-site sarcomas: a retrospective analysis of 131 cases. J Feline Med Surg, 20, 509-519.
  • Phelps HA, Kuntz CA, Milner RJ, Powers BE, Bacon NJ (2011): Radical excision with five-centimeter margins for treatment of feline injection-site sarcomas: 91 cases (1998–2002). Journal of the American Veterinary Medical Association, 239, 97-106.
  • Poirier VJ, Thamm DH, Kurzman ID, Jeglum KA, Chun R, Obradovich JE, O'Brien M, Fred RM, Phillips BS, Vail DM (2002): Liposomeencapsulated doxorubicin (doxil) and doxorubicin in the treatment of vaccine-associated sarcoma in cats. J Vet Intern Med, 16, 726-731.
  • Porcellato I, Menchetti L, Brachelente C, Sforna M, Reginato A, Lepri E, Mechelli L (2017): Feline Injection-Site Sarcoma: Matrix Remodeling and Prognosis. Veterinary Pathology, 54, 204-211.
  • Seguin B (2002): Feline injection site sarcomas. The Veterinary Clinics of North America – Small Animal, 32, 983-995.
  • Terry JL, Milovancev M, Nemanic S, Löhr CV (2017): Quantification of surgical margin length changes after excision of feline injection site sarcomas-A pilot study. Vet Surg. 46, 189-196.
  • Wilcock B, Wilcock A, Bottoms K (2012): Feline postvaccinal sarcoma: 20 years later. Can Vet J, 53, 430-434.
  • Zabielska-Koczywąs K, Wojtalewicz A, Lechowski R (2017): Current knowledge on feline injection-site sarcoma treatment. Acta Vet Scand, 59, 47.
  • Zardo KM, Damiani LP, Matera JM, Fonseca-Pinto AC (2016): Recurrent and non-recurrent feline injection-site sarcoma: computed tomographic and ultrasonographic findings. J Feline Med Surg, 18, 773-782.

Kedi Enjeksiyon İlişkili Sarkomalar: 18 Kedide Cerrahi Sonuçlar

Year 2019, Volume: 90 Issue: 1, 22 - 29, 15.01.2019
https://doi.org/10.33188/vetheder.483641

Abstract

Bu
çalışmanın amacı kedilerde enjeksiyon sonrası şekillenen aşı ilişkili
sarkomalarının tanısını ve cerrahi sonuçlarını bildirmektir. Çalışma kapsamında
enjeksiyon sonrası kitle şekillenmesi şikayetiyle getirilen farklı cinsiyet,
yaş ve kilolardaki 18 kedi değerlendirildi. Kitlelerin çoğunlukla interscapular
(n:7), lumbal (n:5) gibi deri altı enjeksiyon uygulamalarında sıklıkla tercih
edilen bölgelerde şekillendiği tespit edildi. Cerrahi olarak mümkün olduğunca
geniş ensizyon ile kitleler uzaklaştırıldı. Histopatolojik incelemelerde
fibrosarkom (n:12), fibroosteokondrosarkom (n:4), fibromikzosarkom (n:2) tanısı
konuldu. İntraopetif olarak 13 olguda derin kas dokusu ve çevre dokulara
infiltrasyon tespit edildi.  Cerrahi
sonrası 14 olguda 3 ay-1 yıl arası değişen sürelerde nüks şekillendi. Nüks
şekillenen olguların tamamında kitle bir önceki operasyon hattında şekillendiği
ve uzak doku metastazı yapmadığı görüldü

References

  • Bregazzi VS, LaRue SM, McNiel E, McNiel E, Macy DW, Dernell WS, Powers BE, Withrow SJ (2001): Treatment with a combination of doxorubicin, surgery, and radiation versus surgery and radiation alone for cats with vaccine-associated sarcomas: 25 cases (1995–2000). J Am Vet Med Assoc, 218, 547-550.
  • Carminato A, Vascellari M, Marchioro W, Melchiotti E, Mutinelli F (2011): Microchip-associated fibrosarcoma in a cat. Vet Dermatol, 22, 565-569.
  • Cora R, Gal Af, Taulescu M, Tăbăran F, Vidrighinescu R, Cătoı C (2017): Description of a feline injection-site fibrosarcoma with metastasis in the cerebellum. Acta Vet Hung, 67, 578-586.
  • Couto SS, Griffey SM, Duarte PC, Madewell BR, 2002: Feline vaccine-associated fibrosarcoma: morphologic distinctions. Vet Pathol., 39, 33-41.
  • Davidson EB, Gregory CR, Kass PH (1997): Surgical excision of soft tissue fibrosarcomas in cats. Vet Surg, 26, 265-9.
  • Eckstein C, Guscetti F, Roos M, Martín de las Mulas J, Kaser-Hotz B, Rohrer Bley C (2009): A retrospective analysis of radiation therapy for the treatment of feline vaccine-associated sarcoma. Vet Comp Oncol, 7, 54-68.
  • Ferrari R, Di Giancamillo M, Stefanello D, Giudice C, Grieco V, Longo M, Ravasio G, Boracchi P (2017): Clinical and computed tomography tumour dimension assessments for planning wide excision of injection site sarcomas in cats: how strong is the agreement? Vet Comp Oncol, 15, 374-382.
  • Hahn KA, Endicott MM, King GK (2007): Evauation of radiotherapy alone or in combination with doxorubicin chemotherapy for the treatment of cats with incompletely excised soft tissue sarcomas: 71 cases (1989–1999). J Am Vet Med Assoc, 231,742-745.
  • Hartmann K, Day MJ, Thiry E, Lloret A, Frymus T, Addie D, Boucraut-Baralon C, Egberink H, Gruffydd-Jones T, Horzinek MC, Hosie MJ, Lutz H, Marsilio F, Pennisi MG, Radford AD, Truyen U, Möstl K (2015): European Advisory Board on Cat Diseases. Feline injection-site sarcoma: ABCD guidelines on prevention and management. J Feline Med Surg, 17, 606-13.
  • Hendrick MJ, Brooks JJ (1994): Postvaccinal sarcomas in the cat: histology and immunohistochemistry. Vet Pathol, 31, 126-129.
  • Hendrick MJ (2016): Mesenchymal Tumors of the Skin and Soft Tissues. In “Tumors in Domestic Animals”, Ed; Meuten DJ, Iowa State Press, IA.
  • Hill J, Lawrence J, Saba C, Turek M, Feldhaeusser B, Coutermarsh-Ott S, Barber J, Smith J, Gogal RJ (2014): In vitro efficacy of doxorubicin and etoposide against a feline injection site sarcoma cell line. Res Vet Sci, 97, 348-56.
  • Holtermann N, Kiupel M, Hirschberger J (2017): The tyrosine kinase inhibitor toceranib in feline injection site sarcoma: efficacy and side effects. Vet Comp Oncol, 15, 632-640.
  • Kass, P.H., Spangler, W.L., Hendrick, M.J., McGill, L.D., Esplin, D.G., Lester, S., Slater, M., Meyer, E.K., Boucher, F., Peters, E.M., Gobar, G.G., Htoo, T. (2003): Multicenter case-control study of risk factors associated with development of vaccineassociated sarcomas in cats. Journal of the American Veterinary Medical Association, 223, 1283-1292.
  • Longo M, Zani DD, Ferrari R, Bassi J, Andreis M, Stefanello D, Giudice C, Grieco V, Liuti T, Handel I, Di Giancamillo M. (2018): Dynamic tomographic studies of interscapular feline injection-site sarcoma: essential or useless practice? J Feline Med Surg, 20, 502-508.
  • Luna, LE (1968): Manual of Histological Staining Methods of the Armed Forces Institute of Pathology. McGraw-Hill, New York.
  • Martano M, Morello E and Buracco P. (2011): Feline injection-site sarcoma: past, present and future perspectives. The Veterinary Journal, 188, 136-141.
  • Martano M, Morello E, Iussich S, Buracco P. (2012): A case of feline injection-site sarcoma at the site of cisplatin injections. J Feline Med Surg, 14, 751-754.
  • McEntee MC, Page RL (2001): Feline vaccine-associated sarcomas. Journal of Veterinary Internal Medicine, 15, 176-182.
  • Müller N, Kessler M (2018): Curative-intent radical en bloc resection using a minimum of a 3 cm margin in feline injection-site sarcomas: a retrospective analysis of 131 cases. J Feline Med Surg, 20, 509-519.
  • Phelps HA, Kuntz CA, Milner RJ, Powers BE, Bacon NJ (2011): Radical excision with five-centimeter margins for treatment of feline injection-site sarcomas: 91 cases (1998–2002). Journal of the American Veterinary Medical Association, 239, 97-106.
  • Poirier VJ, Thamm DH, Kurzman ID, Jeglum KA, Chun R, Obradovich JE, O'Brien M, Fred RM, Phillips BS, Vail DM (2002): Liposomeencapsulated doxorubicin (doxil) and doxorubicin in the treatment of vaccine-associated sarcoma in cats. J Vet Intern Med, 16, 726-731.
  • Porcellato I, Menchetti L, Brachelente C, Sforna M, Reginato A, Lepri E, Mechelli L (2017): Feline Injection-Site Sarcoma: Matrix Remodeling and Prognosis. Veterinary Pathology, 54, 204-211.
  • Seguin B (2002): Feline injection site sarcomas. The Veterinary Clinics of North America – Small Animal, 32, 983-995.
  • Terry JL, Milovancev M, Nemanic S, Löhr CV (2017): Quantification of surgical margin length changes after excision of feline injection site sarcomas-A pilot study. Vet Surg. 46, 189-196.
  • Wilcock B, Wilcock A, Bottoms K (2012): Feline postvaccinal sarcoma: 20 years later. Can Vet J, 53, 430-434.
  • Zabielska-Koczywąs K, Wojtalewicz A, Lechowski R (2017): Current knowledge on feline injection-site sarcoma treatment. Acta Vet Scand, 59, 47.
  • Zardo KM, Damiani LP, Matera JM, Fonseca-Pinto AC (2016): Recurrent and non-recurrent feline injection-site sarcoma: computed tomographic and ultrasonographic findings. J Feline Med Surg, 18, 773-782.
There are 28 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Surgery
Journal Section RESEARCH ARTICLE
Authors

Murat Çalışkan

Gözde Yücel Tenekeci

Publication Date January 15, 2019
Submission Date November 16, 2018
Acceptance Date December 12, 2018
Published in Issue Year 2019 Volume: 90 Issue: 1

Cite

Vancouver Çalışkan M, Yücel Tenekeci G. Kedi Enjeksiyon İlişkili Sarkomalar: 18 Kedide Cerrahi Sonuçlar. Vet Hekim Der Derg. 2019;90(1):22-9.

Veteriner Hekimler Derneği Dergisi (Journal of Turkish Veterinary Medical Society) is an open access publication, and the journal’s publication model is based on Budapest Access Initiative (BOAI) declaration. All published content is licensed under a Creative Commons CC BY-NC 4.0 license, available online and free of charge. Authors retain the copyright of their published work in Veteriner Hekimler Derneği Dergisi (Journal of Turkish Veterinary Medical Society). 

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