Lipin Protein Ailesi

Yıl 2018, Cilt: 7 Sayı: 3, 102 - 107, 30.09.2018

Birgül Vanizör Kural Sevil Kör

Öz

Lipin
proteinleri hem fosfatidik asidin diaçilgliserole defosforilasyonunu
kalatizleyen fosfatitat fosfataz enzimi olarak hem de DNA-bağımlı transkripsiyon faktörlerinin
koregülatörü olarak fonksiyon görürler. Bu fonksiyonları ile özellikle
triaçilgliserol ve fosfolipid metabolizmasında önemli rol üstlenirler. Lipin
protein genleri insan için LPIN geni
ve diğer memeliler için lpin geni
şeklinde ifade edilmektedir. Memelilerde doku spesifik ekspresyonlarına göre lipin-1, lipin-2 ve
lipin-3 olmak üç lipin paralogu vardır. Ayrıca lipin-1’in insanda a, β ve g izoformları mevcuttur. Lipin-1 en fazla adipoz doku ve
iskelet kasında; lipin-2 en fazla karaciğer ve beyinde; lipin-3 ise gastrointestinal sistemde
bulunur. Bu derlemenin amacı lipin proteinlerinin çeşitleri, yapıları ve genel
fonksiyonları hakkında bilgi vermektir.

Anahtar Kelimeler

Lipin, Fosfatidat Fosfataz

Kaynakça

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