Oksitosinin hücresel tedavide kullanılma potansiyeli

Yıl 2015, Cilt: 1 Sayı: 3, 163 - 169, 07.12.2015

Gözde Sır Esra Arısu Gürkan Yiğittürk Türker Çavuşoğlu Çığır Biray Avcı Servet Çelik Oytun Erbaş Yiğit Uyanıkgil

Öz

Oksitosin dokuz aminoasitten oluşan bir memeli peptit hormonudur. Hipotalamusun supraoptik ve paraventriküler çekirdeklerinden sentezlenir ve beyinde nöromodülatör olarak görev alır. Bu nörotransmitterin doğum sırasında, sonrasında ve üremede önemli görevleri vardır. Uterus kaslarının kasılmasını uyararak doğumu kolaylaştırır. Aynı zamanda doğum süresince beyni hipoksiden koruyucu etkisi vardır. Oksitoksin dişilerde menstrüel siklusun düzenlenmesini sağlarken erkek genital sisteminde ejakulasyonda görev yapar. Oksitoksin otizm gibi sosyal etkileşim ve iletişime zarar veren hastalıklarda tekrarlayan davranışları azaltmaktadır. Günümüzde otoksin tedavisi ve hücresel çalışmalar popülarite kazanmıştır. Oksitosin meme kanseri ve diğer tümör hücrelerinin çoğalmasını engellemektedir. Oksitoksin kök hücrelerin kardiyomiyosit oluşumunu ve farklılaşmayı düzenler. Oksitoksin kalpte apoptozu önleyici etki göstermektedir. Oksitoksin kök hücreler ile birlikte inflamasyonu azaltır. Anjiyogenezi uyarır ve iskemi-reperfüzyon hasarında kardiyak onarımı sağlar. Oksitosin tedavilerin avantajı, hücre üretimini organizmanın kendi kendine gerçekleştirmesinin sağlanması ve hiçbir yan etkisinin görülmemesidir.

Anahtar Kelimeler

Apoptoz, oksitosin, rejenerasyon, kök hücre

Kaynakça

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