Öz
Aim: Pemphigus vulgaris (PV) is an autoimmune blistering skin disease. The aim of this study is to determine the relationship between the neutrophil-to-lymphocyte ratio (NLR) and PV. Methods: A total of 49 newly diagnosed patients with PV and 48 healthy controls were included in the study. The patients were grouped into mild, moderate and severe types according to the dose of administered corticosteroids. All data was obtained using inpatient records. Disease severity, findings on physical examination, complete blood count (CBC), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) parameters were noted. Lymphocyte and neutrophil numbers were noted from CBC findings. The NLR was compared between the patients and controls and among the patient groups. Analysis of data was done using SPSS 15.0. Results: Neutrophil count, NLR, ESR and CRP levels of the patients with PV were higher than the controls (p<0.001, p=0.002, p<0.001, p<0.001, respectively). NLR, CRP and ESR were not correlated with disease activity. Conclusion: NLR has been shown to be a useful indicator of disease severity and prognosis in many diseases. This study demonstrates that it is a parameter distinguishing patients with PV from healthy controls
Anahtar Kelimeler
Neutrophil-to-Lymphocyte Ratio Pemphigus Vulgaris İnflammation
Kaynakça
- Eming R, Nagel A, Wolff-Franke S, et al. Rituximab exerts a dual effect in pemphigus vulgaris. J Invest Dermatol 2008; 128(12): 2850-8.
- Kim EY, Moudgil KD. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunol Lett 2008; 120(1-2): 1–5.
- D’Auria L, Bonifati C, Mussi A, et al. Cytokines in the sera of patients with pemphigus vulgaris: interleukin-6 and tumour necrosis factor-alpha levels are significantly increased as compared to healthy subjects and correlate with disease activity. Eur Cytokine Netw 1997; 8(4): 383–7.
- Mortazavi H, Babaeijandaghi F, Akbarzadeh M, et al. The influence of systemic therapy on the serum levels of IL-6 and IL-8 in pemphigus vulgaris. J Eur Acad Dermatol Venereol 2013; 27(3): 387-90.
- Keskin D, Stern J, Fridkis-Hareli M, Razzaque Ahmed A. Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy. Cytokine 2008; 41(3): 315–21.
- Tirado-Sánchez A, Vázquez-González D, Ponce-Olivera RM, Montes de Oca-Sánchez G. Serum lactate is a useful predictor of death in severe sepsis in patients with pemphigus vulgaris. Acta Dermatovenerol Alp Panonica Adriat. 2012; 21(1): 7-9.
- Yazdanpanah MJ, Ghayour-Mobarhan M, Taji A, et al. Serum zinc and copper status in Iranian patients with pemphigus vulgaris. Int J Dermatol. 2011; 50(11): 1343-6.
- Yesilova Y, Ucmak D, Selek S, et al. Oxidative stress index may play a key role in patients with pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2013; 27(4): 465-7.
- Yousefi M, Rahimi H, Barikbin B, et al. Uric Acid: a new antioxidant in patients with pemphigus vulgaris. Indian J Dermatol. 2011; 56(3): 278-81.
- Franquini Junior J, Adad SJ, Murta AH, de Morais Ca, Teixeira Vde P, Rodrgues Junior V. Tests of inflammatory activity in endemic pemphigus foliaceus. Rev Soc Bras Med Trop. 1994; 27(1): 25-9.
- Lee GK, Lee LC, Chong E, et al. The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction. QJM 2012; 105(11): 1075–82.
- Nunez J, Nunez E, Bodi V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008; 101(6): 747–52.
- Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Atherosclerosis 2013; 228(1): 203–10.
- Buyukkaya E, Karakas MF, Karakas E, et al. Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome. Clin Appl Thromb Hemost 2012; 20(2): 159-63.
- Günay E, Sarınç Ulaşlı S, Akar O, et al. Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease: A Retrospective Study. Inflammation. 2014; 37(2): 374-80.
- Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008; 102(6): 653–7.
- Keizman D, Ish-Shalom M, Huang P, et al. The association of pretreatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma. Eur J Cancer 2012; 48(2): 202–8.
- Yamanaka T, Matsumoto S, Teramukai S, et al. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 7383-4: 215–20.
- Walsh SR, Cook EJ, Goulder F, et al. Neutrophil–lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91(3): 181–4.
- Sharaiha RZ, Halazun KJ, Mirza F, et al. Elevated preoperative neutrophil: Lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol 2011; 18(12): 3362–9.
- Gomez D, Morris-Stiff G, Toogood GJ, et al. Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol 2008; 97(6): 513–8.
- Coventry BJ, Ashdown ML, Quinn MA, Markovic SN, Yatomi- Clarke SL, Robinson AP. CRP identifies homeostatic immune oscillations in cancer patients: a potential treatment targeting tool? J Transl Med. 2009; 7: 102.
- Lee S, Choe JW, Kim HK, Sung J. High-Sensitivity C-Reactive Protein and Cancer. J Epidemiol 2011; 21(3): 161-8.
- Aysalar U, Sandıkçı S, Akpınar E, Saatçi E. Eritrosit Sedimantasyon Hızı ve C-Reaktif Protein: Hâlâ Değerli mi? Türk Aile Hek Derg 2007; 11(4): 154-62.
Öz
Amaç: Pemfigus vulgaris (PV), otoimmün kökenli, bül oluşumuyla seyreden bir deri hastalığıdır. Bu çalışmanın amacı, PV hastalarındaki inflamasyon ile nötrofil-lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Çalışmaya 49 yeni tanı konan pemfigus vulgaris hastası ile 48 sağlıklı birey dahil edildi. Hastalar, hastalığın şiddetine bağlı olarak başlanan steroid dozuna göre; hafif, orta ve şiddetli hastalık olarak üç alt grupta sınıflandırıldı. Tüm veriler yatan hasta kayıtlarının incelenmesiyle elde edildi. Tüm hastalarda hastalık şiddet indeksi, muayene bulguları, tam kan sayımı (TKS), C reaktif protein (CRP) ve eritrosit sedimentasyon hızı (ESH) incelendi. Lenfosit ve nötrofil sayısı TKS verilerinden not edildi. Nötrofil-lenfosit oranı (NLO), hastalık alt grupları arasında ve kontroller ile SPSS 15,0 programı kullanılarak karşılaştırıldı. Bulgular: Çalışmamızda nötrofil sayısı, NLO, ESH ve CRP düzeyleri pemfiguslu hastalarda kontrollerden yüksekti (sırasıyla, p<0,001, p=0,002, p<0,001, p<0,001). NLO, CRP ve ESH düzeyleri hastalık şiddet skoruyla korele değildi. Sonuç: NLO’nun birçok hastalıkta şiddet ve prognoz belirteci olarak kullanışlı ve yararlı bir parametre olduğu saptanmıştır. Kolayca hesaplanan bu ölçeğin, PV’li hastalarda da kontrollerden ayırt edici bir gösterge olduğu saptandı
Anahtar Kelimeler
Kaynakça
- Eming R, Nagel A, Wolff-Franke S, et al. Rituximab exerts a dual effect in pemphigus vulgaris. J Invest Dermatol 2008; 128(12): 2850-8.
- Kim EY, Moudgil KD. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunol Lett 2008; 120(1-2): 1–5.
- D’Auria L, Bonifati C, Mussi A, et al. Cytokines in the sera of patients with pemphigus vulgaris: interleukin-6 and tumour necrosis factor-alpha levels are significantly increased as compared to healthy subjects and correlate with disease activity. Eur Cytokine Netw 1997; 8(4): 383–7.
- Mortazavi H, Babaeijandaghi F, Akbarzadeh M, et al. The influence of systemic therapy on the serum levels of IL-6 and IL-8 in pemphigus vulgaris. J Eur Acad Dermatol Venereol 2013; 27(3): 387-90.
- Keskin D, Stern J, Fridkis-Hareli M, Razzaque Ahmed A. Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy. Cytokine 2008; 41(3): 315–21.
- Tirado-Sánchez A, Vázquez-González D, Ponce-Olivera RM, Montes de Oca-Sánchez G. Serum lactate is a useful predictor of death in severe sepsis in patients with pemphigus vulgaris. Acta Dermatovenerol Alp Panonica Adriat. 2012; 21(1): 7-9.
- Yazdanpanah MJ, Ghayour-Mobarhan M, Taji A, et al. Serum zinc and copper status in Iranian patients with pemphigus vulgaris. Int J Dermatol. 2011; 50(11): 1343-6.
- Yesilova Y, Ucmak D, Selek S, et al. Oxidative stress index may play a key role in patients with pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2013; 27(4): 465-7.
- Yousefi M, Rahimi H, Barikbin B, et al. Uric Acid: a new antioxidant in patients with pemphigus vulgaris. Indian J Dermatol. 2011; 56(3): 278-81.
- Franquini Junior J, Adad SJ, Murta AH, de Morais Ca, Teixeira Vde P, Rodrgues Junior V. Tests of inflammatory activity in endemic pemphigus foliaceus. Rev Soc Bras Med Trop. 1994; 27(1): 25-9.
- Lee GK, Lee LC, Chong E, et al. The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction. QJM 2012; 105(11): 1075–82.
- Nunez J, Nunez E, Bodi V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008; 101(6): 747–52.
- Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Atherosclerosis 2013; 228(1): 203–10.
- Buyukkaya E, Karakas MF, Karakas E, et al. Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome. Clin Appl Thromb Hemost 2012; 20(2): 159-63.
- Günay E, Sarınç Ulaşlı S, Akar O, et al. Neutrophil-to-Lymphocyte Ratio in Chronic Obstructive Pulmonary Disease: A Retrospective Study. Inflammation. 2014; 37(2): 374-80.
- Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 2008; 102(6): 653–7.
- Keizman D, Ish-Shalom M, Huang P, et al. The association of pretreatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma. Eur J Cancer 2012; 48(2): 202–8.
- Yamanaka T, Matsumoto S, Teramukai S, et al. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 7383-4: 215–20.
- Walsh SR, Cook EJ, Goulder F, et al. Neutrophil–lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91(3): 181–4.
- Sharaiha RZ, Halazun KJ, Mirza F, et al. Elevated preoperative neutrophil: Lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol 2011; 18(12): 3362–9.
- Gomez D, Morris-Stiff G, Toogood GJ, et al. Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol 2008; 97(6): 513–8.
- Coventry BJ, Ashdown ML, Quinn MA, Markovic SN, Yatomi- Clarke SL, Robinson AP. CRP identifies homeostatic immune oscillations in cancer patients: a potential treatment targeting tool? J Transl Med. 2009; 7: 102.
- Lee S, Choe JW, Kim HK, Sung J. High-Sensitivity C-Reactive Protein and Cancer. J Epidemiol 2011; 21(3): 161-8.
- Aysalar U, Sandıkçı S, Akpınar E, Saatçi E. Eritrosit Sedimantasyon Hızı ve C-Reaktif Protein: Hâlâ Değerli mi? Türk Aile Hek Derg 2007; 11(4): 154-62.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Ağustos 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 7 Sayı: 2 |