TİMOLOL/BRİNZOLOMİD KOMBİNASYONU İLE TİMOLOL/DORZOLOMİD KOMBİNASYONUN GÖZ TANSİYONU AÇISINDAN KARŞILAŞTIRILMASI

Yıl 2014, Cilt: 5 Sayı: 17, 1 - 5, 03.03.2015

Ahmet Elbeyli Yusuf Kibar

https://doi.org/10.17944/mkutfd.53660

Öz

Amaç: Bu çalışmanın amacı timolol/dorzolamid ve
timolol/brinzolamid sabit kombinasyon ilaçlarının
göz içi basıncı üzerine etkisini karşılaştırmaktır.
Gereç ve Yöntem: Bu retrospektif bir çalışmadır.
Monoterapiye rağmen intraoküler basıncı yüksek
olan ve kombinasyon tedavisine geçilen primer açık
açılı glokom hastaları çalışmaya dahil edildi. .
Toplam 50 hastanın 50 gözü çalışmaya alınmıştır
(timolol /dorzolamid grubunda 26, timolol
/brinzolamid grubunda 24 hasta). İridokorneal açıda
sineşi olmayan, hikayesinde başka herhangi bir göz
hastalığı olan veya herhangi bir göz ameliyatı
geçiren hastalar çalışmaya dahil edilmemiştir.
Kaydedilmiş olan 4.hafta ve 4.ay göz içi basınç
değerleri karşılaştırıldı.

Bulgular: Bazal intraoküler basınç değeri
timolol/dorzolamid grubunda 23,2±3,3 (17-28
mmHg), timolol/brinzolamid grubunda ise 23,1±2,8
(17-28 mmHg) olarak bulundu. 4.hafta sonunda
elde edilen intraoküler basınç değerleri timolol/
dorzolomid grubunda 15,3 ±2,3 (11-20mmHg),
timolol/brinzolomid grubunda ise 15,8±2,7(11-
19mmHg) idi. Bu değerler arasında istatistiksel
olarak anlamlı fark bulunamadı. 4.ay sonunda elde
edilen İOB değerleri timolol/dorzolamid grubunda
15,8±3,1 (11-21mmHg), timolol/brinzolomid
grubunda ise 16,1±2,8 (12-22mmHg) olarak
bulundu. Bu değerler arasında istatistiksel olarak
anlamlı fark bulunamadı.
Sonuç: Her iki ilaçta intraoküler basıncı başarılı bir
şekilde düşürmüştür fakat 4.hafta ve 4.ay değerleri
arasında istatistiksel olarak anlamlı bir fark yoktur.

Anahtar Kelimeler

Timolol/Brinzolomid, Timolol/Dorzolomid, Göz Tansiyonu

Comparison the effect of timolol/brinzolomid and timolol/ dorzolamid fixedcombination drugs on intraocular pressure

Öz

Objective: The aim of this study is to compare the effect timolol/brinzolomid fixed-combination drugs on intraocular pressure. Materials and Methods: This is a retrospective study. The primary open angle glaucoma patients that were switched to fixed-combination drugs due to high intraocular pressure despite monotherapy were included to the study. The intraocular pressure records of 4.week and 4.month were compared. Results: The baseline intraocular pressure levels were timolol/dorzolamid group and 23,1±2,8 (17-28 mmHg) in timolol/brinzolamid group. After 4.weeks of combination treatment intraocular pressure levels were 15,3 ±2,3 mmHg (1120mmHg) in timolol/ dorzolomid and 15,8±2,7(1119mmHg) in timolol/brinzolomid. After 4.nmonths of combination treatment intraocular pressure levels were 15,8±3,1 (11-21mmHg) in timolol/dorzolamid group timolol/brinzolomid group. There statistically significant difference between the groups. Conclusion: Both fixed combination drugs decreased the intraocular pressure successfully but there was no statistically significant difference between intraocular pressure levels at 4.week and 4.month. Key dorzolamid

Anahtar Kelimeler

timolol/brinzolomid, timolol/ dorzolamid, intraocular pressure

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