Araştırma Makalesi
Maternal Serum D Vitamini Seviyesinin Gebelik Sonuçlarına Etkisi
Öz
Amaç: D
vitamini kalsiyum dengesi ve kemik sağlığının sağlanmasında önemli bir yağda
çözünen vitamindir. D vitamini eksikliği tüm dünyayı etkileyen önemli bir halk
sağlığı sorunudur. Bu çalışmanın amacı; bölgemizdeki gebelerin D vitamini
seviyesini saptamak ve olası gebelik komplikasyonları ile olan ilişkisini
değerlendirmektir.
Materyal ve Metod: Kesitsel
tipte yapılan bu çalışmaya kadın hastalıkları ve doğum
polikliniğine rutin gebelik muayenesi için başvuran 175 gebe dahil edildi. Çalışmaya
katılan gebelerin demografik özellikleri ve obstetrik hikayeleri kayıt edildi.
Maternal serum D vitamini seviyeleri ile gebelik sonuçları karşılaştırıldı.
Bulgular: Çalışmaya
katılan gebelerin ortalama serum D vitamini değeri 11,16±7,15 ng/ml olarak
saptandı ve gebelerin % 57.7’sinde ciddi D vitamini eksikliği (< 10 ng/ml) vardı.
Gebelik sonuçları ile maternal D vitamini seviyeleri arasında ilişki
saptanmadı.
Sonuç:
Çalışmamızda ciddi D vitamini eksikliğinin % 57.7 olarak saptanmasına rağmen maternal
D vitamini seviyeleri ile gebelik sonuçları arasında herhangi bir ilişki
saptanmadı.
Anahtar Kelimeler
Kaynakça
- 1. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences–. The American journal of clinical nutrition. 2008;87(4):1080S-6S.
- 2. Öğüş E, Sürer H, Kılınç A, Fidancı V, Yılmaz G, Dindar N, et al. D Vitamini düzeylerinin aylara, cinsiyete ve yaşa göre değerlendirilmesi. Ankara Medical Journal. 2014;15(1).
- 3. Holick MF. Vitamin D deficiency. New England Journal of Medicine. 2007;357(3):266-81.
- 4. Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermato-endocrinology. 2013;5(1):51-108.
- 5. Ates S, Sevket O, Ozcan P, Ozkal F, Kaya MO, Dane B. Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes. African health sciences. 2016;16(1):36-43.
- 6. Lerchbaum E, Obermayer-Pietsch B. Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. European Journal of Endocrinology. 2012;166(5):765-78.
- 7. Halloran BP, Deluca HF. Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. The Journal of nutrition. 1980;110(8):1573-80.
- 8. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertility and sterility. 2010;94(4):1314-9.
- 9. Farzadi L, Bidgoli HK, Ghojazadeh M, Bahrami Z, Fattahi A, Latifi Z, et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iranian journal of reproductive medicine. 2015;13(6):361.
- 10. Saraf R, Morton SM, Camargo Jr CA, Grant CC. Global summary of maternal and newborn vitamin D status–a systematic review. Maternal & child nutrition. 2016;12(4):647-68.
- 11. Zhang C, Qiu C, Hu FB, David RM, Van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PloS one. 2008;3(11):e3753.
- 12. Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between vitamin D deficiency and primary cesarean section. The Journal of Clinical Endocrinology & Metabolism. 2009;94(3):940-5.
- 13. Boyle VT, Thorstensen EB, Mourath D, Jones MB, McCowan LM, Kenny LC, et al. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. British Journal of Nutrition. 2016;116(8):1409-15.
- 14. Kumar P, Shenoi A, Kumar RK, Girish S, Subbaiah S. Vitamin D Deficiency Among Women in Labor and Cord Blood of Newborns. Indian pediatrics. 2015;52(6):530-1.
- 15. Bowyer L, Catling‐Paull C, Diamond T, Homer C, Davis G, Craig ME. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clinical endocrinology. 2009;70(3):372-7.
- 16. Mahon P, Harvey N, Crozier S, Inskip H, Robinson S, Arden N, et al. Low maternal vitamin D status and fetal bone development: cohort study. Journal of Bone and Mineral Research. 2010;25(1):14-9.
- 17. Ponsonby A-L, Lucas RM, Lewis S, Halliday J. Vitamin D status during pregnancy and aspects of offspring health. Nutrients. 2010;2(3):389-407.
- 18. Perez-Lopez FR. Vitamin D: the secosteroid hormone and human reproduction. Gynecological endocrinology. 2007;23(1):13-24.
- 19. Thorne‐Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta‐analysis. Paediatric and perinatal epidemiology. 2012;26:36-54.
- 20. Prasad D, Smita KS, Nisha S. Vitamin D in Pregnancy and its Correlation with Feto Maternal Outcome. Age. 2018;30(69):31.
- 21. Boyle VT, Thorstensen EB, Mourath D, Jones MB, McCowan LM, Kenny LC, et al. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. The British journal of nutrition. 2016;116(8):1409-15.
- 22. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism. 2011;96(7):1911-30.
- 23. Kolusari A, Kurdoglu M, Yildizhan R, Adali E, Edirne T, Cebi A, et al. Catalase activity, serum trace element and heavy metal concentrations, and vitamin A, D and E levels in pre-eclampsia. The Journal of international medical research. 2008;36(6):1335-41.
- 24. Hofmeyr GJ, Lawrie TA, Atallah ÁN, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database of Systematic Reviews. 2018(10).
- 25. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. The Journal of Clinical Endocrinology & Metabolism. 2007;92(9):3517-22.
- 26. Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, et al. Vitamin D supplementation in pregnancy: a systematic review. Health technology assessment (Winchester, England). 2014;18(45):1-190.
- 27. Muscogiuri G, Mitri J, Mathieu C, Badenhoop K, Tamer G, Orio F, et al. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. European journal of endocrinology. 2014;171(3):R101-R10.
- 28. Harinarayan C, Arvind S, Joshi S, Thennarasu K, Vedavyas V, Baindur A. Improvement in pancreatic β-cell function with vitamin D and calcium supplementation in vitamin D-deficient nondiabetic subjects. Endocrine Practice. 2013;20(2):129-38.
- 29. Perez-Ferre N, Torrejon M, Fuentes M, Fernandez M, Ramos A, Bordiu E, et al. Association of low serum 25-hydroxyvitamin D levels in pregnancy with glucose homeostasis and obstetric and newborn outcomes. Endocrine Practice. 2012;18(5):676-84.
- 30. Zhou J, Su L, Liu M, Liu Y, Cao X, Wang Z, et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. European journal of clinical nutrition. 2014;68(8):925.
- 31. Pérez-López FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertility and sterility. 2015;103(5):1278-88. e4.
- 32. Hossain N, Kanani FH, Ramzan S, Kausar R, Ayaz S, Khanani R, et al. Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in Pakistani women. The Journal of Clinical Endocrinology & Metabolism. 2014;99(7):2448-55.
- 33. Hashemipour S, Ziaee A, Javadi A, Movahed F, Elmizadeh K, Javadi EH, et al. Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2014;172:15-9.
The Effect of Maternal Serum Vitamin D Level on Pregnancy Results
Öz
Aim: Vitamin D is a
important fat-soluble vitamin that is maintaining calcium balance and bone
health. Vitamin D deficiency is an important public health problem affecting
the whole world. The aim of this study; to determine the vitamin D level of
pregnant women in our region and to evaluate the relationship with possible
pregnancy complications.
Material and Method: This
cross - sectional study included 175 pregnant women who were admitted to the
obstetrics and gynecology outpatient clinic for routine pregnancy examination.
Demographic characteristics and obstetric history of the pregnant women were
recorded. Maternal serum vitamin D levels and pregnancy outcomes were compared.
Results:
The mean serum vitamin D value of the pregnant women was 11.16 ± 7.15 ng/ml and
57.7% of the pregnant women had severe vitamin D deficiency (<10 ng/ml).
There was no correlation between pregnancy outcomes and maternal vitamin D
levels.
Conclusion: In
our study, although severe vitamin D deficiency was found to be 57.7%, there
was no correlation between maternal vitamin D levels and pregnancy outcomes.
Anahtar Kelimeler
Kaynakça
- 1. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences–. The American journal of clinical nutrition. 2008;87(4):1080S-6S.
- 2. Öğüş E, Sürer H, Kılınç A, Fidancı V, Yılmaz G, Dindar N, et al. D Vitamini düzeylerinin aylara, cinsiyete ve yaşa göre değerlendirilmesi. Ankara Medical Journal. 2014;15(1).
- 3. Holick MF. Vitamin D deficiency. New England Journal of Medicine. 2007;357(3):266-81.
- 4. Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermato-endocrinology. 2013;5(1):51-108.
- 5. Ates S, Sevket O, Ozcan P, Ozkal F, Kaya MO, Dane B. Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes. African health sciences. 2016;16(1):36-43.
- 6. Lerchbaum E, Obermayer-Pietsch B. Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. European Journal of Endocrinology. 2012;166(5):765-78.
- 7. Halloran BP, Deluca HF. Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. The Journal of nutrition. 1980;110(8):1573-80.
- 8. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertility and sterility. 2010;94(4):1314-9.
- 9. Farzadi L, Bidgoli HK, Ghojazadeh M, Bahrami Z, Fattahi A, Latifi Z, et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iranian journal of reproductive medicine. 2015;13(6):361.
- 10. Saraf R, Morton SM, Camargo Jr CA, Grant CC. Global summary of maternal and newborn vitamin D status–a systematic review. Maternal & child nutrition. 2016;12(4):647-68.
- 11. Zhang C, Qiu C, Hu FB, David RM, Van Dam RM, Bralley A, et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PloS one. 2008;3(11):e3753.
- 12. Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between vitamin D deficiency and primary cesarean section. The Journal of Clinical Endocrinology & Metabolism. 2009;94(3):940-5.
- 13. Boyle VT, Thorstensen EB, Mourath D, Jones MB, McCowan LM, Kenny LC, et al. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. British Journal of Nutrition. 2016;116(8):1409-15.
- 14. Kumar P, Shenoi A, Kumar RK, Girish S, Subbaiah S. Vitamin D Deficiency Among Women in Labor and Cord Blood of Newborns. Indian pediatrics. 2015;52(6):530-1.
- 15. Bowyer L, Catling‐Paull C, Diamond T, Homer C, Davis G, Craig ME. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clinical endocrinology. 2009;70(3):372-7.
- 16. Mahon P, Harvey N, Crozier S, Inskip H, Robinson S, Arden N, et al. Low maternal vitamin D status and fetal bone development: cohort study. Journal of Bone and Mineral Research. 2010;25(1):14-9.
- 17. Ponsonby A-L, Lucas RM, Lewis S, Halliday J. Vitamin D status during pregnancy and aspects of offspring health. Nutrients. 2010;2(3):389-407.
- 18. Perez-Lopez FR. Vitamin D: the secosteroid hormone and human reproduction. Gynecological endocrinology. 2007;23(1):13-24.
- 19. Thorne‐Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta‐analysis. Paediatric and perinatal epidemiology. 2012;26:36-54.
- 20. Prasad D, Smita KS, Nisha S. Vitamin D in Pregnancy and its Correlation with Feto Maternal Outcome. Age. 2018;30(69):31.
- 21. Boyle VT, Thorstensen EB, Mourath D, Jones MB, McCowan LM, Kenny LC, et al. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. The British journal of nutrition. 2016;116(8):1409-15.
- 22. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism. 2011;96(7):1911-30.
- 23. Kolusari A, Kurdoglu M, Yildizhan R, Adali E, Edirne T, Cebi A, et al. Catalase activity, serum trace element and heavy metal concentrations, and vitamin A, D and E levels in pre-eclampsia. The Journal of international medical research. 2008;36(6):1335-41.
- 24. Hofmeyr GJ, Lawrie TA, Atallah ÁN, Torloni MR. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database of Systematic Reviews. 2018(10).
- 25. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. The Journal of Clinical Endocrinology & Metabolism. 2007;92(9):3517-22.
- 26. Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, et al. Vitamin D supplementation in pregnancy: a systematic review. Health technology assessment (Winchester, England). 2014;18(45):1-190.
- 27. Muscogiuri G, Mitri J, Mathieu C, Badenhoop K, Tamer G, Orio F, et al. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. European journal of endocrinology. 2014;171(3):R101-R10.
- 28. Harinarayan C, Arvind S, Joshi S, Thennarasu K, Vedavyas V, Baindur A. Improvement in pancreatic β-cell function with vitamin D and calcium supplementation in vitamin D-deficient nondiabetic subjects. Endocrine Practice. 2013;20(2):129-38.
- 29. Perez-Ferre N, Torrejon M, Fuentes M, Fernandez M, Ramos A, Bordiu E, et al. Association of low serum 25-hydroxyvitamin D levels in pregnancy with glucose homeostasis and obstetric and newborn outcomes. Endocrine Practice. 2012;18(5):676-84.
- 30. Zhou J, Su L, Liu M, Liu Y, Cao X, Wang Z, et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. European journal of clinical nutrition. 2014;68(8):925.
- 31. Pérez-López FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertility and sterility. 2015;103(5):1278-88. e4.
- 32. Hossain N, Kanani FH, Ramzan S, Kausar R, Ayaz S, Khanani R, et al. Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in Pakistani women. The Journal of Clinical Endocrinology & Metabolism. 2014;99(7):2448-55.
- 33. Hashemipour S, Ziaee A, Javadi A, Movahed F, Elmizadeh K, Javadi EH, et al. Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2014;172:15-9.
Toplam 33 adet kaynakça vardır.
Kaynak Göster
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