Derleme
BibTex RIS Kaynak Göster

Lokal ve Sistemik Renin Anjiyotensin Sistemi

Yıl 2019, Cilt: 28 Sayı: 4, 259 - 269, 31.12.2019

Öz

Renin
Anjiyotensin Sisteminin (RAS) atheroskleroz ve hipertansiyon gibi
kardiyovasküler hastalıkların fizyopatolojisinde önemli rol oynadığı
bildirilmektedir. Vasküler düz kas ve endotel hücresinin RAS, lipoproteinler ve
insülinle etkileşimi, diyabet, miyokart enfarktüs, hipertansiyon, inme ve stent
restenozu gibi hastalıkların gelişimine ve ilerlemesine neden olarak
gösterilmektedir. Sistemik RAS daha çok kan basıncının düzenlenmesini, tuz ve
su alımını, antidiüretik hormon (ADH) salınımını sağlarken, lokal RAS
vasküler düz kas
hücrelerinin çoğalması, büyümesi, apopitoz ve inflamasyonunda görev almaktadır.
Çalışmalarda, RAS bileşenlerinin vasküler düz kas, kalp hücresi, yağ dokusu ve
beyin gibi birçok yerde lokal olarak sentezlendiği gösterilmiştir. Vasküler
yapı üzerine hem sistemik hem de lokal olarak sentez edilip etki gösteren
RAS’ın patolojik süreçlerdeki intrasellüler etki mekanizmaları tam olarak
aydınlatılamamıştır. Bu yüzden lokal RAS’ın bileşenlerinin tam anlamıyla
aydınlatılması yeni tedavi yöntemlerinin geliştirilmesinde önemli rol
oynayacaktır.

Kaynakça

  • 1. Fyhrquist F, Saijonmaa O. Renin-angiotensin system revisited. Journal of internal medicine, 2008; 264(3):224-236.2. Hussain M, Awan FR. Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease. Clinical and experimental hypertension, 2018; 40(4):344-352.3. Schmidt-Ott KM, Kagiyama S, Phillips MI. The multiple actions of angiotensin II in atherosclerosis. Regulatory peptides, 2000; 93(1-3):65-77.4. Mehta PK,Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. American journal of physiology Cell physiology, 2007; 292(1):C82-97.5. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S. Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clinical science, 2007; 112(8):417-428.6. Abuissa H, Jones PG, Marso SP, O'Keefe JH, Jr. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials. Journal of the American College of Cardiology, 2005; 46(5):821-826.7. Touyz RM, Berry C. Recent advances in angiotensin II signaling. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2002; 35(9):1001-1015.8. Kim E. Barrett P, Scott Boitano P, Susan M. Barman P, Heddwen L. Brooks P. Ganong's Review of Medical Physiology McGraw-Hill Education, 2016.9. Bihl JC, Zhang C, Zhao Y, Xiao X, Ma X, Chen Y, Chen S, Zhao B, Chen Y. Angiotensin-(1-7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the NFsmall ka, CyrillicB inflammatory pathway. Vascular pharmacology, 2015; 73(115-123.10. Guo DF, Sun YL, Hamet P, Inagami T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell research, 2001; 11(3):165-180.11. Massiera F, Bloch-Faure M, Ceiler D, Murakami K, Fukamizu A, Gasc JM, Quignard-Boulange A, Negrel R, Ailhaud G, Seydoux J, Meneton P ve Teboul M. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001; 15(14):2727-2729.12. Rosendorff C. The renin-angiotensin system and vascular hypertrophy. Journal of the American College of Cardiology, 1996; 28(4):803-812.13. Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev, 2006; 86(3):747-803.14. Kumar R, Singh VP, Baker KM. The intracellular renin-angiotensin system: a new paradigm. Trends in endocrinology and metabolism: TEM, 2007; 18(5):208-214.15. Peach MJ. Renin-angiotensin system: biochemistry and mechanisms of action. Physiol Rev, 1977; 57(2):313-370.16. Jiang X, Sheng HH, Lin G, Li J, Lu XZ, Cheng YL, Huang J, Xiao HS, Zhan YY. Effect of renin-angiotensin-aldosterone system gene polymorphisms on blood pressure response to antihypertensive treatment. Chinese medical journal, 2007; 120(9):782-786.17. Boron WF, Boulpaep EL. Medical Physiology. Elsevier, 2017.18. Brunton LL, Parker KL, Blumenthal DK, Buxton ILO. Goodman & Gilman’s Manual of Pharmacology and Therapeutics: The McGraw-Hill Companies, 2008.19. Atlas SA. The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. Journal of managed care pharmacy : JMCP, 2007; 13(8 Suppl B):9-20.20. Griendling KK, Ushio-Fukai M, Lassegue B, Alexander RW. Angiotensin II signaling in vascular smooth muscle. New concepts. Hypertension, 1997; 29(1 Pt 2):366-373.21. Leung PS. The physiology of a local renin-angiotensin system in the pancreas. The Journal of physiology, 2007; 580(Pt 1):31-37.22. Giacchetti G, Sechi LA, Rilli S, Carey RM. The renin-angiotensin-aldosterone system, glucose metabolism and diabetes. Trends in endocrinology and metabolism: TEM, 2005; 16(3):120-126.23. Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacological reviews, 2000; 52(4):639-672.24. Heeneman S, Sluimer J, Daemen MJ. Angiotensin-converting enzyme and vascular remodeling. Circulation research, 2007; 101(5):441-454.25. Mifune M, Sasamura H, Shimizu-Hirota R, Miyazaki H, Saruta T. Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells. Hypertension, 2000; 36(5):845-850.26. Igarashi M, Hirata A, Nozaki H, Kadomoto-Antsuki Y, Tominaga M. Role of angiotensin II type-1 and type-2 receptors on vascular smooth muscle cell growth and glucose metabolism in diabetic rats. Diabetes research and clinical practice, 2007; 75(3):267-277.27. Yue Y, Ma K, Li Z, Wang Z. Angiotensin II type 1 receptor-associated protein regulates carotid intimal hyperplasia through controlling apoptosis of vascular smooth muscle cells. Biochemical and biophysical research communications, 2018; 495(2):2030-2037.28. Yamada T, Akishita M, Pollman MJ, Gibbons GH, Dzau VJ, Horiuchi M. Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study. Life sciences, 1998; 63(19):PL289-295.29. Berk BC, Vekshtein V, Gordon HM, Tsuda T. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension, 1989; 13(4):305-314.30. Burnier M. Angiotensin II type 1 receptor blockers. Circulation, 2001; 103(6):904-912.31. Tambelline N, Oliveira K, Olchanheski LR, Sordi R, Otuki MF, Favero GM, Fernandes D. The Effect of Losartan on Angiotensin II-Induced Cell Proliferation in a Rat Aorta Smooth Muscle Cell Line. Braz Arch Biol Techn, 2012; 55(2):263-268.32. Iwanami J, Mogi M, Tsukuda K, Jing F, Ohshima K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Min LJ ve Horiuchi M. Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice. European journal of pharmacology, 2014; 724(9-15.33. Namsolleck P, Boato F, Schwengel K, Paulis L, Matho KS, Geurts N, Thone-Reineke C, Lucht K, Seidel K, Hallberg A, Dahlof B, Unger T, Hendrix S, Steckelings UM. AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression. Neurobiology of disease, 2013; 51(177-191.34. Castoldi G, di Gioia CR, Bombardi C, Maestroni S, Carletti R, Steckelings UM, Dahlof B, Unger T, Zerbini G, Stella A. Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats. American journal of physiology Renal physiology, 2014; 307(10):F1123-1131.35. Dhande I, Ma W, Hussain T. Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertension research : official journal of the Japanese Society of Hypertension, 2015; 38(1):21-29.36. McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE. Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. PloS one, 2014; 9(4):e95762.37. O. K. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji: Hacettepe-Taş, 2002.38. Bian J, Zhang S, Yi M, Yue M, Liu H. The mechanisms behind decreased internalization of angiotensin II type 1 receptor. Vascular pharmacology, 2018.39. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circulation research, 1994; 74(6):1141-1148.40. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K, Griendling KK. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. The Journal of biological chemistry, 1999; 274(32):22699-22704.41. Phillips MI, Speakman EA ve Kimura B. Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Regulatory peptides, 1993; 43(1-2):1-20.42. Weiss D, Sorescu D, Taylor WR. Angiotensin II and atherosclerosis. The American journal of cardiology, 2001; 87(8A):25C-32C.43. Baker KM, Kumar R. Intracellular angiotensin II induces cell proliferation independent of AT1 receptor. American journal of physiology Cell physiology, 2006; 291(5):C995-1001.44. Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B, Anversa P. Myocardial cell death in human diabetes. Circulation research, 2000; 87(12):1123-1132.45. Re R, Parab M. Effect of angiotensin II on RNA synthesis by isolated nuclei. Life sciences, 1984; 34(7):647-651.46. Re RN, Vizard DL, Brown J, Bryan SE. Angiotensin II receptors in chromatin fragments generated by micrococcal nuclease. Biochemical and biophysical research communications, 1984; 119(1):220-227.47. Filipeanu CM, Henning RH, de Zeeuw D, Nelemans A. Intracellular Angiotensin II and cell growth of vascular smooth muscle cells. British journal of pharmacology, 2001; 132(7):1590-1596.48. Haller H, Lindschau C, Erdmann B, Quass P, Luft FC. Effects of intracellular angiotensin II in vascular smooth muscle cells. Circulation research, 1996; 79(4):765-772.49. Jandeleit-Dahm K,Cooper ME. Hypertension and diabetes: role of the renin-angiotensin system. Endocrinology and metabolism clinics of North America, 2006; 35(3):469-490, vii.50. Fukuda N, Satoh C, Hu WY, Soma M, Kubo A, Kishioka H, Watanabe Y, Izumi Y, Kanmatsuse K. Production of angiotensin II by homogeneous cultures of vascular smooth muscle cells from spontaneously hypertensive rats. Arteriosclerosis, thrombosis, and vascular biology, 1999; 19(5):1210-1217.51. Vidotti DB, Casarini DE, Cristovam PC, Leite CA, Schor N, Boim MA. High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. American journal of physiology Renal physiology, 2004; 286(6):F1039-1045.52. Lavrentyev EN, Estes AM, Malik KU. Mechanism of high glucose induced angiotensin II production in rat vascular smooth muscle cells. Circulation research, 2007; 101(5):455-464.53. Natarajan R, Scott S, Bai W, Yerneni KK, Nadler J. Angiotensin II signaling in vascular smooth muscle cells under high glucose conditions. Hypertension, 1999; 33(1 Pt 2):378-384.54. Von Bohlen und Halbach O, Albrecht D. The CNS renin-angiotensin system. Cell and tissue research, 2006; 326(2):599-616.55. Thone-Reineke C, Steckelings UM, Unger T. Angiotensin receptor blockers and cerebral protection in stroke. Journal of hypertension Supplement : official journal of the International Society of Hypertension, 2006; 24(1):S115-121.56. Achard V, Boullu-Ciocca S, Desbriere R, Nguyen G, Grino M. Renin receptor expression in human adipose tissue. American journal of physiology Regulatory, integrative and comparative physiology, 2007; 292(1):R274-282.57. Engeli S, Schling P, Gorzelniak K, Boschmann M, Janke J, Ailhaud G, Teboul M, Massiera F, Sharma AM. The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome? The international journal of biochemistry & cell biology, 2003; 35(6):807-825.
Yıl 2019, Cilt: 28 Sayı: 4, 259 - 269, 31.12.2019

Öz

Kaynakça

  • 1. Fyhrquist F, Saijonmaa O. Renin-angiotensin system revisited. Journal of internal medicine, 2008; 264(3):224-236.2. Hussain M, Awan FR. Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease. Clinical and experimental hypertension, 2018; 40(4):344-352.3. Schmidt-Ott KM, Kagiyama S, Phillips MI. The multiple actions of angiotensin II in atherosclerosis. Regulatory peptides, 2000; 93(1-3):65-77.4. Mehta PK,Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. American journal of physiology Cell physiology, 2007; 292(1):C82-97.5. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S. Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clinical science, 2007; 112(8):417-428.6. Abuissa H, Jones PG, Marso SP, O'Keefe JH, Jr. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials. Journal of the American College of Cardiology, 2005; 46(5):821-826.7. Touyz RM, Berry C. Recent advances in angiotensin II signaling. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2002; 35(9):1001-1015.8. Kim E. Barrett P, Scott Boitano P, Susan M. Barman P, Heddwen L. Brooks P. Ganong's Review of Medical Physiology McGraw-Hill Education, 2016.9. Bihl JC, Zhang C, Zhao Y, Xiao X, Ma X, Chen Y, Chen S, Zhao B, Chen Y. Angiotensin-(1-7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the NFsmall ka, CyrillicB inflammatory pathway. Vascular pharmacology, 2015; 73(115-123.10. Guo DF, Sun YL, Hamet P, Inagami T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell research, 2001; 11(3):165-180.11. Massiera F, Bloch-Faure M, Ceiler D, Murakami K, Fukamizu A, Gasc JM, Quignard-Boulange A, Negrel R, Ailhaud G, Seydoux J, Meneton P ve Teboul M. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001; 15(14):2727-2729.12. Rosendorff C. The renin-angiotensin system and vascular hypertrophy. Journal of the American College of Cardiology, 1996; 28(4):803-812.13. Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev, 2006; 86(3):747-803.14. Kumar R, Singh VP, Baker KM. The intracellular renin-angiotensin system: a new paradigm. Trends in endocrinology and metabolism: TEM, 2007; 18(5):208-214.15. Peach MJ. Renin-angiotensin system: biochemistry and mechanisms of action. Physiol Rev, 1977; 57(2):313-370.16. Jiang X, Sheng HH, Lin G, Li J, Lu XZ, Cheng YL, Huang J, Xiao HS, Zhan YY. Effect of renin-angiotensin-aldosterone system gene polymorphisms on blood pressure response to antihypertensive treatment. Chinese medical journal, 2007; 120(9):782-786.17. Boron WF, Boulpaep EL. Medical Physiology. Elsevier, 2017.18. Brunton LL, Parker KL, Blumenthal DK, Buxton ILO. Goodman & Gilman’s Manual of Pharmacology and Therapeutics: The McGraw-Hill Companies, 2008.19. Atlas SA. The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. Journal of managed care pharmacy : JMCP, 2007; 13(8 Suppl B):9-20.20. Griendling KK, Ushio-Fukai M, Lassegue B, Alexander RW. Angiotensin II signaling in vascular smooth muscle. New concepts. Hypertension, 1997; 29(1 Pt 2):366-373.21. Leung PS. The physiology of a local renin-angiotensin system in the pancreas. The Journal of physiology, 2007; 580(Pt 1):31-37.22. Giacchetti G, Sechi LA, Rilli S, Carey RM. The renin-angiotensin-aldosterone system, glucose metabolism and diabetes. Trends in endocrinology and metabolism: TEM, 2005; 16(3):120-126.23. Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacological reviews, 2000; 52(4):639-672.24. Heeneman S, Sluimer J, Daemen MJ. Angiotensin-converting enzyme and vascular remodeling. Circulation research, 2007; 101(5):441-454.25. Mifune M, Sasamura H, Shimizu-Hirota R, Miyazaki H, Saruta T. Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells. Hypertension, 2000; 36(5):845-850.26. Igarashi M, Hirata A, Nozaki H, Kadomoto-Antsuki Y, Tominaga M. Role of angiotensin II type-1 and type-2 receptors on vascular smooth muscle cell growth and glucose metabolism in diabetic rats. Diabetes research and clinical practice, 2007; 75(3):267-277.27. Yue Y, Ma K, Li Z, Wang Z. Angiotensin II type 1 receptor-associated protein regulates carotid intimal hyperplasia through controlling apoptosis of vascular smooth muscle cells. Biochemical and biophysical research communications, 2018; 495(2):2030-2037.28. Yamada T, Akishita M, Pollman MJ, Gibbons GH, Dzau VJ, Horiuchi M. Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study. Life sciences, 1998; 63(19):PL289-295.29. Berk BC, Vekshtein V, Gordon HM, Tsuda T. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension, 1989; 13(4):305-314.30. Burnier M. Angiotensin II type 1 receptor blockers. Circulation, 2001; 103(6):904-912.31. Tambelline N, Oliveira K, Olchanheski LR, Sordi R, Otuki MF, Favero GM, Fernandes D. The Effect of Losartan on Angiotensin II-Induced Cell Proliferation in a Rat Aorta Smooth Muscle Cell Line. Braz Arch Biol Techn, 2012; 55(2):263-268.32. Iwanami J, Mogi M, Tsukuda K, Jing F, Ohshima K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Min LJ ve Horiuchi M. Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice. European journal of pharmacology, 2014; 724(9-15.33. Namsolleck P, Boato F, Schwengel K, Paulis L, Matho KS, Geurts N, Thone-Reineke C, Lucht K, Seidel K, Hallberg A, Dahlof B, Unger T, Hendrix S, Steckelings UM. AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression. Neurobiology of disease, 2013; 51(177-191.34. Castoldi G, di Gioia CR, Bombardi C, Maestroni S, Carletti R, Steckelings UM, Dahlof B, Unger T, Zerbini G, Stella A. Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats. American journal of physiology Renal physiology, 2014; 307(10):F1123-1131.35. Dhande I, Ma W, Hussain T. Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertension research : official journal of the Japanese Society of Hypertension, 2015; 38(1):21-29.36. McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE. Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. PloS one, 2014; 9(4):e95762.37. O. K. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji: Hacettepe-Taş, 2002.38. Bian J, Zhang S, Yi M, Yue M, Liu H. The mechanisms behind decreased internalization of angiotensin II type 1 receptor. Vascular pharmacology, 2018.39. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circulation research, 1994; 74(6):1141-1148.40. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K, Griendling KK. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. The Journal of biological chemistry, 1999; 274(32):22699-22704.41. Phillips MI, Speakman EA ve Kimura B. Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Regulatory peptides, 1993; 43(1-2):1-20.42. Weiss D, Sorescu D, Taylor WR. Angiotensin II and atherosclerosis. The American journal of cardiology, 2001; 87(8A):25C-32C.43. Baker KM, Kumar R. Intracellular angiotensin II induces cell proliferation independent of AT1 receptor. American journal of physiology Cell physiology, 2006; 291(5):C995-1001.44. Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B, Anversa P. Myocardial cell death in human diabetes. Circulation research, 2000; 87(12):1123-1132.45. Re R, Parab M. Effect of angiotensin II on RNA synthesis by isolated nuclei. Life sciences, 1984; 34(7):647-651.46. Re RN, Vizard DL, Brown J, Bryan SE. Angiotensin II receptors in chromatin fragments generated by micrococcal nuclease. Biochemical and biophysical research communications, 1984; 119(1):220-227.47. Filipeanu CM, Henning RH, de Zeeuw D, Nelemans A. Intracellular Angiotensin II and cell growth of vascular smooth muscle cells. British journal of pharmacology, 2001; 132(7):1590-1596.48. Haller H, Lindschau C, Erdmann B, Quass P, Luft FC. Effects of intracellular angiotensin II in vascular smooth muscle cells. Circulation research, 1996; 79(4):765-772.49. Jandeleit-Dahm K,Cooper ME. Hypertension and diabetes: role of the renin-angiotensin system. Endocrinology and metabolism clinics of North America, 2006; 35(3):469-490, vii.50. Fukuda N, Satoh C, Hu WY, Soma M, Kubo A, Kishioka H, Watanabe Y, Izumi Y, Kanmatsuse K. Production of angiotensin II by homogeneous cultures of vascular smooth muscle cells from spontaneously hypertensive rats. Arteriosclerosis, thrombosis, and vascular biology, 1999; 19(5):1210-1217.51. Vidotti DB, Casarini DE, Cristovam PC, Leite CA, Schor N, Boim MA. High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. American journal of physiology Renal physiology, 2004; 286(6):F1039-1045.52. Lavrentyev EN, Estes AM, Malik KU. Mechanism of high glucose induced angiotensin II production in rat vascular smooth muscle cells. Circulation research, 2007; 101(5):455-464.53. Natarajan R, Scott S, Bai W, Yerneni KK, Nadler J. Angiotensin II signaling in vascular smooth muscle cells under high glucose conditions. Hypertension, 1999; 33(1 Pt 2):378-384.54. Von Bohlen und Halbach O, Albrecht D. The CNS renin-angiotensin system. Cell and tissue research, 2006; 326(2):599-616.55. Thone-Reineke C, Steckelings UM, Unger T. Angiotensin receptor blockers and cerebral protection in stroke. Journal of hypertension Supplement : official journal of the International Society of Hypertension, 2006; 24(1):S115-121.56. Achard V, Boullu-Ciocca S, Desbriere R, Nguyen G, Grino M. Renin receptor expression in human adipose tissue. American journal of physiology Regulatory, integrative and comparative physiology, 2007; 292(1):R274-282.57. Engeli S, Schling P, Gorzelniak K, Boschmann M, Janke J, Ailhaud G, Teboul M, Massiera F, Sharma AM. The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome? The international journal of biochemistry & cell biology, 2003; 35(6):807-825.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Zehra Çiçek 0000-0003-3205-5463

Kübra Akıllıoğlu Bu kişi benim 0000-0003-4896-8822

Ayşe Dogan Bu kişi benim 0000-0002-6508-5266

Yayımlanma Tarihi 31 Aralık 2019
Kabul Tarihi 22 Ekim 2018
Yayımlandığı Sayı Yıl 2019 Cilt: 28 Sayı: 4

Kaynak Göster

AMA Çiçek Z, Akıllıoğlu K, Dogan A. Lokal ve Sistemik Renin Anjiyotensin Sistemi. aktd. Aralık 2019;28(4):259-269.