Genetik Geçişli Nöromüsküler Hastalığı Olan Bireylerin Depresyon Düzeyi ve İlişkili Faktörler

Yıl 2023, Cilt: 12 Sayı: 3, 509 - 515, 28.09.2023

Askeri Turken Habip Balsak Fatma Ayhan

https://doi.org/10.53424/balikesirsbd.1240449

Öz

Amaç: Bu çalışmanın amacı, farklı ambulasyon düzeylerine sahip Genetik Geçişli Nöromüsküler Hastalığı (GNMH) olan bireylerin depresyon ve anksiyete düzeyinin belirlenmesi ve etkileyen faktörlerin tespit edilmesidir. Gereç ve Yöntem: Tanımlayıcı olarak tasarlanan çalışmanın evrenini Gazi Yaşargil Eğitim Araştırma Hastanesi Kas Hasatlıkları kliniğinde GNMH tanısı ile takip edilen hastalar oluşturmaktadır. Farklı ambulasyon seviyelerindeki 159 hastanın dahil edildiği çalışmanın verileri sosyodemografik veri formu, Beck Depresyon ölçeği (BDÖ), Beck Anksiyete ölçeği (BAÖ) ve Fiziksel Ambulasyon Skalası (FAS) aracılığı ile toplanmıştır. Bulgular: Çalışmaya katılanların yaş ortalaması 21.03 ± 9.35 ve %55.3’ü erkektir. Katılımcıların %24.5’i fonksiyonel olmayan, %15.7’si gözetimli bağımlı, %59.7’si tam bağımsız seviyesinde fiziksel ambulasyon düzeyine sahiptir. Çalışmaya katılanların önemli bölümü orta ve şiddetli düzeyde anksiyete seviyesine sahip olup, genel BAÖ puan ortalaması 20.44±10.25’ tir. Katılımcıların BDÖ genel puan ortalaması 21.03±9.35’tir. Hafif ve ileri düzey depresyon belirtisi gösterenlerin oranı ise %76.1’dir. GHMH tanılı bireylerde ileri yaş (p<0.05) ve fiziksel bağımlılık düzeyinin yüksek olması (p<0.05) depresyon ve anksiyete düzeyini olumsuz etkileyen önemli değişkenler olarak tespit edilmiştir. Sonuç: Özellikle ileri yaş ve bağımlı fiziksel ambulasyon seviyesinin önemli birer risk faktörü olduğu sonucuna ulaşılmıştır.

Anahtar Kelimeler

Anxiety, Depression, Neuromuscular Disease

Depression Levels and Associated Factors in Individuals with Hereditary Neuromuscular Disease

Öz

Objective: The purpose of this study was to determine depression and anxiety levels in individuals diagnosed with Hereditary Neuromuscular Diseases (HNMDs) with differing degrees of ambulation, and the factors affecting those levels. Materials and Methods: The study population in this descriptive study consisted of patients under follow-up with diagnoses of HNMD at the Gazi Yaşargil Education and Research Hospital muscular diseases clinic. One hundred fifty-nine patients with varying degrees of ambulation were included. The study data were collected using a sociodemographic data form, the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), and the Functional Ambulation Classification (FAC). Results: The participants’ mean age was 21.03 ± 9.35 years, and 55.3% were male. Physical ambulation levels were nonfunctional in 24.5% of participants, dependent on supervision in 15.7%, and independent in 59.7%. A significant part of the participants had moderate or severe anxiety levels. The general BAI score was 20.44±10.25, and the general BDI score was 21.03±9.35. Mild and severe depressive symptoms were present in 76.1% of the participants. Advanced age (p<0.05) and high physical dependence levels (p<0.05) emerged as significant variables adversely affecting depression and anxiety levels. Conclusion: It was concluded that especially advanced age and dependent physical ambulation level are important risk factors.

Anahtar Kelimeler

Anxiety, Depression, Neuromuscular Disease

Destekleyen Kurum

No support was received from any institution for the project.

Kaynakça

• Akdeniz, D., Em, S., Caglayan, M. (2015). Determination of sleep quality and associated factors in stroke patients. Fırat Medical Journal, 20(2), 86-91.
• Aytap, F., & Özer, Z. (2021). The relationship between risk of depression levels and disease management ındividuals with chronic diseases and affecting Factors. Turkish Journal of Family Medicine and Primary Care, 15(2), 212-222. https://doi.org/ 10.21763/tjfmpc.788814.
• Bats, R. A., & Brown, G. K. (1996). Manual for Beck Depression Inventory-II, San Antonio (TX). Psychological Corporation. Access: 01.07.2022. https://www.nctsn.org/measures/beck-depression-inventory-second-edition.
• Beck, A. T., Steer, R. A., & Carbin, M. G. (1988). Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review, 8(1), 77-100.
• Bogdan, A., Barnett, C., Ali, A., AlQwaifly, M., Abraham, A., Mannan, S., & et al. (2020). Chronic stress, depression and personality type in patients with myasthenia gravis. European Journal of Neurology, 27(1), 204-209. https://doi.org/10.1111/ ene.14057.
• Carey, I. M., Banchoff, E., Nirmalananthan, N., Harris, T., DeWilde, S., Chaudhry, U. A., & Cook, D. G. (2021). Prevalence and incidence of neuromuscular conditions in the UK between 2000 and 2019: A retrospective study using primary care data. Plos One, 16(12), e0261983.
• Dahlqvist, J. R., Widholm, P., Leinhard, O. D., & Vissing, J. (2020). MRI in neuromuscular diseases: An emerging diagnostic tool and biomarker for prognosis and efficacy. Annals of Neurology, 88(4), 669-681. https://doi.org/10.1002/ana.25804.
• Darmahkasih, A. J., Rybalsky, I., Tian, C., Shellenbarger, K. C., Horn, P. S., Lambert, J. T., & Wong, B. L. (2020). Neurodevelopmental, behavioral, and emotional symptoms common in Duchenne muscular dystrophy. Muscle & Nerve, 61(4), 466-474. https:// doi.org/10.1002/mus.26803.
• Deenen, J. C., Horlings, C. G., Verschuuren, J. J., Verbeek, A. L., & van Engelen, B. G. (2015). The epidemiology of neuromuscular disorders: A comprehensive overview of the literature. Journal of Neuromuscular Diseases, 2(1), 73-85. https://doi.org/10.3233/JND-140045.
• Feng, X., Liu, C., Xi, J., Sun, C., Yue, D., Zhu, W., Li, J., Liang, Z., Lu, J., & Luo, S. (2020). The correlation of clinical evaluation with life quality and mental status in a Chinese cohort with dysferlinopathy. Journal of Clinical Neuroscience, 81, 259-264. https://doi.org /10.1016/j.jocn.2020.09.069.
• Finder, J. D. (2021). Respiratory Complications in neuromuscular disorders. In T. Bertorini (Ed.), Neuromuscular disorder (p.323). Elsevier Health Sciences.
• Hisli, N. (1989). A reliability and validity study of Beck Depression Inventory in a university student sample. Journal of Psychology, 7(23), 3-13.
• Liu, Y., & Tang, X. (2018). Depressive syndromes in autoimmune disorders of the nervous system: prevalence, etiology, and influence. Frontiers in Psychiatry, 9(451), 1-9. https://doi.org/10.3389 /fpsyt.2018.0045.
• Messina, S., Vita, G. L., Sframeli, M., Mondello, S., Mazzone, E., et al. (2016). Health-related quality of life and functional changes in DMD: A 12-month longitudinal cohort study. Neuromuscular Disorders, 26(3), 189-196. http://dx.doi.org/ 10.1016/ j.nmd.2016.01.00.
• Mori-Yoshimura, M., Mizuno, Y., Yoshida, S., Ishihara, N., Minami, N., Morimoto, E., et al. (2019). Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy. Neuromuscular Disorders, 29(12), 930-939. https://doi.org/10.1016/ j.nmd.2019.09.006.
• Müller, K. I., Ghelue, M. V., Lund, I., Jonsrud, C., & Arntzen, K. A. (2021). The prevalence of hereditary neuromuscular disorders in Northern Norway. Brain and Behavior, 11(1), e01948. https://doi.org/ 10.1002 /brb3.1948.
• Nadali, J., Ghavampour, N., Beiranvand, F., Maleki Takhtegahi, M., Heidari, M. E., Salarvand, S., et al. (2023). Prevalence of depression and anxiety among myasthenia gravis (MG) patients: A systematic review and meta‐analysis. Brain and Behavior, 13(1), e2840. https://doi.org/10.1002/brb3.2840.
• O'Dowd, D. N., Bostock, E. L., Smith, D., Morse, C. I., Orme, P., & Payton, C. J. (2021). Psychological parameters impact health-related quality of life in mental and physical domains in adults with muscular dystrophy. Neuromuscular Disorders, 31(4), 328-335. https://doi.org/10.1016/j.nmd.2021.01.007.
• Ozer, S., Yildirim, S. A., Yilmaz, O., Duger, T., & Yilmaz, S. A. (2010). Assessment of health-related quality of life, depression, and anxiety in slowly and rapidly progressive neuromuscular disorders. Neurosciences Journal, 15(3), 177-183.
• Parada, P., Oliva, M., Lázaro, E., Amayra, I., Paz, J. F. L., Martínez, O., Jometón, A., Berrocoso, S., Iglesias, A., & Pérez, M. (2014). Anxiety, depression and self-efficacy in patients with myasthenia gravis. International Journal of Psychology and Psychological Therapy, 14(1), 105-113.
• Pascual-Morena, C., Cavero-Redondo, I., Reina-Gutiérrez, S., Saz-Lara, A., López-Gil, J. F., & Martínez-Vizcaíno, V. (2022). Prevalence of neuropsychiatric disorders in Duchenne and Becker muscular dystrophies: a systematic review and meta-analysis. Archives of Physical Medicine and Rehabilitation, 103(12), 2444-2453. https://doi.org/ 10.1016/j.apmr.2022.05.015.
• Peric, M., Peric, S., Stevanovic, J., Milovanovic, S., Basta, I., Nikolic, A., et al. (2018). Quality of life in adult patients with limb–girdle muscular dystrophies. Acta Neurologica Belgica, 118(2), 243-250. https://doi. org/10.1007/s13760-017-0857-9.
• Taylor, L., Wicks, P., Leigh, P. N., & Goldstein, L. H. (2010). Prevalence of depression in amyotrophic lateral sclerosis and other motor disorders. European Journal of Neurology, 17(8), 1047-1053. https:// doi.org/10.1111/j.1468-1.2010.02960.x.
• Ulusoy, M., Sahin, N. H., & Erkmen, H. (1998). Turkish version of the Beck Anxiety Inventory: Psychometric properties. Journal of Cognitive Psychotherapy, 12(2), 163.
• Yao, M., Xia, Y., Feng, Y., Ma, Y., Hong, Y., Zhang, Y., et al. (2021). Anxiety and depression in school-age patients with spinal muscular atrophy: a cross-sectional study. Orphanet Journal of Rare Diseases, 16(1), 1-12. https://doi.org/ 10.1186/ s13023-021-02008-8.
• Winblad, S., Jensen, C., Månsson, J. E., Samuelsson, L., & Lindberg, C. (2010). Depression in myotonic dystrophy type 1: Clinical and neuronal correlates. Behavioral and Brain Functions, 6(1), 1-7.
• WHO. (2017). Other common mental disorders: Global health estimates. Geneva: World Health Organization. Accessed: 22.02.2023. https://www.who.int/health-topics/depression#tab=tab_1.