Pyrethroid Toxication in Cats

Yıl 2020, Cilt: 3 Sayı: 2, 165 - 168, 29.12.2020

Rahmi Canbar Enver Yazar

Öz

Synthetic derivatives were synthesized after determining the effectiveness of the flowers of the Chrysanthemum cinerariaefolium plant against insects. These synthetic derivatives are called pyrethroids. Nowadays, synthetic pyrethroids are widely used as insecticide and ectoparasitic (tick, lice, fleas, scabies). Permethrin, deltamethrin, flumethrin, cypermethrin, fenvalerate and cyfluthrin containing commercial products has been licensed for use in dogs, horses, cattle, sheep and goats in Turkey. Products containing permethrin are widely used in dogs. Mammals are generally not susceptible to pyrethroid, but cats are quite sensitive. Serious poisoning may develops in cats as a result of accidental application of pyrethroids and/or contact of cats with pyrethroids treated dogs. In this review, it could be tried to give information about pyrethroid poisoning, clinical appearance and treatments in cats.

Anahtar Kelimeler

Pyrethroid, cat, poisoning

Proje Numarası

bulunmamaktadır

Kedilerde Piretroid Toksikasyonu

Öz

Chrysanthemum cinerariaefolium bitkisinin çiçeklerinin böceklere karşı etkinliğinin belirlenmesinden sonra sentetik türevleri sentezlenmiştir. Sentetik türevlere piretroidler adı verilmiştir. Günümüzde sentetik piretroidler insektisit ve ektoparaziter (kene, bit, pire, uyuz) amaçla yaygın şekilde kullanılmaktadır. Türkiye’de permetrin, deltametrin, flumetrin, sipermetrin, fenvalerat ve sifulitrin içeren ticari ürünler köpek, at, sığır, koyun ve keçilerde kullanılmak üzere ruhsatlandırılmıştır. Permetrin içeren ürünler köpeklerde oldukça fazla kullanılmaktadır. Memeli türleri genellikle piretroidlere duyarlı değildir. Ancak kediler oldukça duyarlıdır. Kedilere yanlışlıkla piretroid uygulanması ve/veya piretroid uygulanan köpeklerle kedilerin temasa geçmesi sonucunda kedilerde ciddi zehirlenmeler gelişebilmektedir. Bu derlemede kedilerde gözlenen piretroid zehirlenmeleri, klinik görünümü ve tedavileri hakkında bilgiler verilmeye çalışılmıştır.

Anahtar Kelimeler

Piretroid, kedi, zehirlenme

Destekleyen Kurum

bulunmamaktadır

Proje Numarası

bulunmamaktadır

Teşekkür

bulunmamaktadır

Kaynakça

• Amfim A, Simion VE, Parvu M, 2016. Epidemiological and therapeutics approaches in cats pyrethroids poisoning. Lucrari Stiintifice Medicina Veterinara, 49:11-16.
• Anadon A, Martinez-Larranaga MR, Martinez MA, 2009. Use and abuse of pyrethrins and synthetic pyrethroids in veterinary medicine. Vet J, 182:7-20.
• Bahcivan E, Oguz H, 2019. Intravenous lipid emulsion treatment in poisoning. Dicle Univ Vet Fak Derg, 12(1):70-77.
• Balcioglu IC, Kurt O, Ozbilgin A, 2004. Antiparasitic drugs. ANKEM Derg, 18(4):237-244.
• Bates N, 2020. Poisons affecting the neurological system. Vet Nurse, 11:116-125.
• Berny P, Caloni F, Croubels S, Sachana M, Vandenbroucke V, Davanzo F, Guitart R, 2010. Animal poisoning in Europe. Part 2: Companion animals. Vet J, 183:255-259.
• Bertero A, Fossati P, Caloni F, 2020. Indoor poisoning of companion animals by chemicals. Sci Total Environ, 733:139366.
• Boland LA, Angles JM, 2010. Feline permethrin toxicity: retrospective study of 42 cases. J Feline Med Surg, 12:61-71.
• Bruckner M, Schwedes CS, 2012. Successful treatment of permethrin toxicosis in two cats with an intravenous lipid administration. Tierarztliche Praxis Kleintiere, 2:129-134.
• Caloni F, Cortinovis C, Rivolta M, Davanzo F, 2016. Suspected poisoning of domestic animals by pesticides. Sci Total Environ, 539:331-336.
• Ceccherini G, Perondi F, Lippi I, Grazia G, Marchetti V, 2015. Intravenous lipid emulsion and dexmedetomidine for treatment of feline permethrin intoxication: A report from 4 cases. Open Vet J, 5(2):113-121.
• Das YK, Aksoy A, 2016. Pesticides. Turkiye Klinikleri J Vet Sci Pharmacol Toxicol-Special Topics, 2(2):1-17.
• DeGroot WD, 2014. Intravenous lipid emulsion for treating permethrin toxicosis in a cat. Can Vet J, 55:1253-1254.
• Dorman DC, Buck WB, Trammel HL, Jones RD, Beasley VR, 1990. Fenvalerate/N,N-diethyl-m-toluamide (Deet) toxicosis in two cats (abstract). JAVMA, 196(1):100-102.
• Draper WE, Bolfer L, Cottam E, McMichael M, Schubert T, 2013. Methocarbamol CRI for symptomatic treatment of pyrethroid intoxication: A report of three cases. J Am Anim Hosp Assoc, 49(5):325-328.
• Dymond NI, Swift IM, 2008. Permethrin toxicity in cats: A retrospective study of 20 cases. Aust Vet J, 86:219-222.
• Haworth MD, Smart L, 2012. Use of intravenous lipid therapy in three cases of feline permethrin toxicosis. J Vet Emer Crit Care, 22(6):697-702.
• Kuo K, Odunayo A, 2013. Adjunctive therapy with intravenous lipid emulsion and methocarbamol for permethrin toxicity in 2 cats. J Vet Emer Crit Care, 23(4):436-441.
• Merola V, Dunayer E, 2006. The 10 most common toxicosis in cats. Vet Med, 6:339-342.
• Ozkaya G, Celiker A, Kocer-Giray B, 2013. Evaluation of insecticide poisoning and the cases in Turkey. Turk Hij Den Biyol Derg, 70(2):75-102.
• Peacock RE, Hosgood G, Swindells KL, Smart L, 2015. A randomized, controlled clinical trial of intravenous lipid emulsion as an adjunctive treatment for permethrin toxicosis in cats. J Vet Emer Crit Care, 25(5):597-605.
• Richardson JA, 2000. Permethrin spot-on toxicoses in cats. J Vet Emer Crit Care, 10:103-106.
• Seitz MA, Burkitt-Creedon JM, 2016. Persistent gross lipemia and suspected corneal lipidosis following intravenous lipid therapy in a cat with permethrin toxicosis. J Vet Emerg Crit Care, 26(6):804-808.
• Siroka Z, Svobodova Z, 2013. The toxicity and adverse effects of selected drugs in animals – overview. Polish J Vet Sci, 16:181-191.
• Sutton NM, Bates N, Campbell A, 2007. Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons Information Service (VPIS), London. J Feline Med Surg, 9:335-339.
• Taylor S, 2016. Why are cats still dying from permethrin toxicity? Vet Times, August:1-7.
• Woodward KN, 2005. Veterinary pharmacovigilance. Part 2. Veterinary pharmacovigilance in practice – the operation of a spontaneous reporting scheme in a European Union country – the UK, and schemes in other countries. J Vet Pharmacol Therap, 28:149-170.
• Yazar E, 2018. Veterinary Drug and Vaccine from A to Z. Nobel tıp kitapevi, Istanbul, Turkey.
• Yazar E, 2019. Chemotherapeutics, in: Veterinary Drug Guide and Treatment Handbook, Ed: Yazar E, Nobel tıp kitabevi, Istanbul, Turkey.
• Yuh EL, Keir I, 2018. Hypertriglyceridemia and transient corneal lipidosis in a cat following intravenous lipid therapy for permethrin toxicosis. Can Vet J, 59:155-158.