Araştırma Makalesi
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Yıl 2018, Cilt: 10 Sayı: 2, 27 - 31, 07.12.2018

Öz

Kaynakça

  • 1- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013 Jan;36 Suppl 1:S67-74. doi: 10.2337/dc13-S067.
  • 2- Steiner DF, Cunningham D, Spigelman L, Aten B. Insulin biosynthesis: evidence for a precursor. Science 1967;157:697–700.
  • 3- Wahren J, Ekberg K, Jörnvall H. C-peptide is a bioactive peptide. Diabetologia 2007; 50:503–509.
  • 4- Zhang W, Kamiya H, Ekberg K, Wahren J, Sima AA. C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats. Diabetes Metab Res Rev. 2007 Jan;23(1):63-70.
  • 5- Vasic D, Marx N, Sukhova G, et al. C-peptide promotes lesion development in a mouse model of arteriosclerosis. J Cell Mol Med 2012; 16: 927–935.
  • 6- Marx N, Walcher D, Raichle C, et al. C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. Arterioscler Thromb Vasc Biol 2004; 24: 540–545.
  • 7- Walcher D, Babiak C, Poletek P, et al. C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2. Circ Res 2006; 99: 1181–1187.
  • 8- Pikkemaat M, Melander O, Mölstad S, Garberg G, Boström KB. C-peptide concentration, mortality and vascular complications in people with Type 2 diabetes. The Skaraborg Diabetes Register. Diabet Med. 2015 Jan;32(1):85-9. doi:10.1111/dme.12608.
  • 9- Nawal C L, Goyal LK, Kumar V, Gautam A, Agrawal A, Mital P. Serum C-peptide level as a predictor of atherosclerosis and cardiovascular disease in type 2 diabetes mellitus. J Mahatma Gandhi Inst Med Sci 2016;21:25-9
  • 10- Irwin ML, Duggan C, Wang CY, et al. Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and life style study. J Clin Oncol 2011; 29:47 – 53.
  • 11- Vasic D, Marx N, Sukhova G, et al. C-peptide promotes lesion development in a mouse model of arteriosclerosis. J Cell Mol Med 2012; 16: 927–935.
  • 12- Rask-Madsen C and King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab 2013; 17: 20–33.
  • 13- Nikolaus Marx, Guenther Silbernagel, Vincent Brandenburg, et al. Diabetes Care. 2013 Mar; 36(3):708-14
  • 14- Flavio E. Hirai, MPH, Scot E. Moss, MA, Barbara E.K. Klein, Ronald Klein, Diabetes Care. 2008 Mar; 31(3):493-7.

High c-peptide level: marker of mortality in type 2 diabetes mellitus patients

Yıl 2018, Cilt: 10 Sayı: 2, 27 - 31, 07.12.2018

Öz

Objective: We aimed to retrospectively investigate the effect of c-peptide level on mortality in patients with Type 2 Diabetes Mellitus.
Methods: Patients who applied to the Dicle University Medical Faculty in 2012 were screened in the database and included a 1000 DM patient with c-peptide, after 5 years the patients were re-evaluated. The patients were then categorized. The patients were divided into two groups, dead patients and living patients. Two groups of c-peptide levels were compared.
Results: Totally 1000 patients included in the study. 392 (39.2%) of the patients were male and 608 (60.8%) were female, the mean age was 57. Patients were divided into two groups: the patient group who died and the patient group who was living. The number of patients died was 146 (14.6%) and the number of living patients was 844 (75.4%). C-peptide levels were found to be higher in patients who died (3,5 ± 2,7 ng / ml) than those who survived (2,9 ± 1,7 ng / ml) and statistically significant (p<0.05).
Conclusion: The high c-peptide levels in patients with Diabetes Mellitus, it may be an important parameter to predict mortality.

Kaynakça

  • 1- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013 Jan;36 Suppl 1:S67-74. doi: 10.2337/dc13-S067.
  • 2- Steiner DF, Cunningham D, Spigelman L, Aten B. Insulin biosynthesis: evidence for a precursor. Science 1967;157:697–700.
  • 3- Wahren J, Ekberg K, Jörnvall H. C-peptide is a bioactive peptide. Diabetologia 2007; 50:503–509.
  • 4- Zhang W, Kamiya H, Ekberg K, Wahren J, Sima AA. C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats. Diabetes Metab Res Rev. 2007 Jan;23(1):63-70.
  • 5- Vasic D, Marx N, Sukhova G, et al. C-peptide promotes lesion development in a mouse model of arteriosclerosis. J Cell Mol Med 2012; 16: 927–935.
  • 6- Marx N, Walcher D, Raichle C, et al. C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. Arterioscler Thromb Vasc Biol 2004; 24: 540–545.
  • 7- Walcher D, Babiak C, Poletek P, et al. C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2. Circ Res 2006; 99: 1181–1187.
  • 8- Pikkemaat M, Melander O, Mölstad S, Garberg G, Boström KB. C-peptide concentration, mortality and vascular complications in people with Type 2 diabetes. The Skaraborg Diabetes Register. Diabet Med. 2015 Jan;32(1):85-9. doi:10.1111/dme.12608.
  • 9- Nawal C L, Goyal LK, Kumar V, Gautam A, Agrawal A, Mital P. Serum C-peptide level as a predictor of atherosclerosis and cardiovascular disease in type 2 diabetes mellitus. J Mahatma Gandhi Inst Med Sci 2016;21:25-9
  • 10- Irwin ML, Duggan C, Wang CY, et al. Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and life style study. J Clin Oncol 2011; 29:47 – 53.
  • 11- Vasic D, Marx N, Sukhova G, et al. C-peptide promotes lesion development in a mouse model of arteriosclerosis. J Cell Mol Med 2012; 16: 927–935.
  • 12- Rask-Madsen C and King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab 2013; 17: 20–33.
  • 13- Nikolaus Marx, Guenther Silbernagel, Vincent Brandenburg, et al. Diabetes Care. 2013 Mar; 36(3):708-14
  • 14- Flavio E. Hirai, MPH, Scot E. Moss, MA, Barbara E.K. Klein, Ronald Klein, Diabetes Care. 2008 Mar; 31(3):493-7.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Araştırma
Yazarlar

Çiğdem Budak Ece Bu kişi benim

Zafer Pekkolay

Alpaslan Kemal Tuzcu Bu kişi benim

Yayımlanma Tarihi 7 Aralık 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 10 Sayı: 2

Kaynak Göster

APA Ece, Ç. B., Pekkolay, Z., & Tuzcu, A. K. (2018). High c-peptide level: marker of mortality in type 2 diabetes mellitus patients. International Archives of Medical Research, 10(2), 27-31.
AMA Ece ÇB, Pekkolay Z, Tuzcu AK. High c-peptide level: marker of mortality in type 2 diabetes mellitus patients. IAMR. Aralık 2018;10(2):27-31.
Chicago Ece, Çiğdem Budak, Zafer Pekkolay, ve Alpaslan Kemal Tuzcu. “High C-Peptide Level: Marker of Mortality in Type 2 Diabetes Mellitus Patients”. International Archives of Medical Research 10, sy. 2 (Aralık 2018): 27-31.
EndNote Ece ÇB, Pekkolay Z, Tuzcu AK (01 Aralık 2018) High c-peptide level: marker of mortality in type 2 diabetes mellitus patients. International Archives of Medical Research 10 2 27–31.
IEEE Ç. B. Ece, Z. Pekkolay, ve A. K. Tuzcu, “High c-peptide level: marker of mortality in type 2 diabetes mellitus patients”, IAMR, c. 10, sy. 2, ss. 27–31, 2018.
ISNAD Ece, Çiğdem Budak vd. “High C-Peptide Level: Marker of Mortality in Type 2 Diabetes Mellitus Patients”. International Archives of Medical Research 10/2 (Aralık 2018), 27-31.
JAMA Ece ÇB, Pekkolay Z, Tuzcu AK. High c-peptide level: marker of mortality in type 2 diabetes mellitus patients. IAMR. 2018;10:27–31.
MLA Ece, Çiğdem Budak vd. “High C-Peptide Level: Marker of Mortality in Type 2 Diabetes Mellitus Patients”. International Archives of Medical Research, c. 10, sy. 2, 2018, ss. 27-31.
Vancouver Ece ÇB, Pekkolay Z, Tuzcu AK. High c-peptide level: marker of mortality in type 2 diabetes mellitus patients. IAMR. 2018;10(2):27-31.

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