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Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis

Yıl 2022, Cilt: 2 Sayı: 2, 166 - 175, 15.12.2022
https://doi.org/10.55484/ijpbp.1049943

Öz

Nyctanthes arbor-tristis L. contains various phytochemicals with tremendous potential to fight against different infections. However, the effect of these phytochemicals on Mycobacterium tuberculosis is yet unknown. Treatment of multi-drug resistance (MDR) and extensively drug-resistant (XDR) strains of the tuberculosis bacterium are still challenging. Therefore, there is an urgent need to overcome this problem. The present review focuses on the potential action of the hypolipidemic phytochemicals obtained from N. arbor-tristis on the growth and survival of M. tuberculosis in the human host. The extracts from different parts of this plant are hypolipidemic by various established mechanisms. Phytochemicals like iridoids and flavonoids from plant origin exhibit a high capacity to regulate cholesterol and fatty acid biosynthesis in vivo. The hypolipidemic properties of N. arbor-tristis-derived extracts are probably due to the presence of phytochemicals such as iridoids, flavonoids, etc. It may regulate fatty acid biosynthesis in M. tuberculosis by targeting bacterial fatty acid synthase enzyme. Additionally, these phytochemicals also inhibit cholesterol biosynthesis in the host by interrupting the function of HMG-CoA reductase. M. tuberculosis is an intracellular pathogen. It is also established fact as on date that entry of tuberculosis bacterium in the macrophage is macrophage membrane cholesterol-dependent. Host cholesterol is also otherwise necessary by multiple mechanisms for the pathogenesis of tuberculosis. Based on the above facts, we believe that N. arbor-tristis derived phytochemicals can act both on the tuberculosis bacterium and on the host for prevention and cure of tuberculosis.

Teşekkür

We are thankful to Prof. Harish Nayyar, Department of Botany; Amrit P Ghumman, Department of Chemistry, Panjab University; and Dharmjit Singh, Senior Artist, Postgraduate Institute of Medical Education and Research, Chandigarh, India for their precious support.

Kaynakça

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Yıl 2022, Cilt: 2 Sayı: 2, 166 - 175, 15.12.2022
https://doi.org/10.55484/ijpbp.1049943

Öz

Kaynakça

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Toplam 104 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Reviews
Yazarlar

Subendu Sarkar 0000-0002-0706-6374

Rajender Pal Singh Bu kişi benim 0000-0001-5979-1650

Yayımlanma Tarihi 15 Aralık 2022
Gönderilme Tarihi 28 Aralık 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 2 Sayı: 2

Kaynak Göster

APA Sarkar, S., & Singh, R. P. (2022). Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis. International Journal of Plant Based Pharmaceuticals, 2(2), 166-175. https://doi.org/10.55484/ijpbp.1049943
AMA Sarkar S, Singh RP. Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis. Int. J. Plant Bas. Pharm. Aralık 2022;2(2):166-175. doi:10.55484/ijpbp.1049943
Chicago Sarkar, Subendu, ve Rajender Pal Singh. “Nyctanthes Arbor-Tristis L.: Perspective of Phytochemical-Based Inhibition of Fatty Acid Biosynthesis in Mycobacterium Tuberculosis”. International Journal of Plant Based Pharmaceuticals 2, sy. 2 (Aralık 2022): 166-75. https://doi.org/10.55484/ijpbp.1049943.
EndNote Sarkar S, Singh RP (01 Aralık 2022) Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis. International Journal of Plant Based Pharmaceuticals 2 2 166–175.
IEEE S. Sarkar ve R. P. Singh, “Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis”, Int. J. Plant Bas. Pharm., c. 2, sy. 2, ss. 166–175, 2022, doi: 10.55484/ijpbp.1049943.
ISNAD Sarkar, Subendu - Singh, Rajender Pal. “Nyctanthes Arbor-Tristis L.: Perspective of Phytochemical-Based Inhibition of Fatty Acid Biosynthesis in Mycobacterium Tuberculosis”. International Journal of Plant Based Pharmaceuticals 2/2 (Aralık 2022), 166-175. https://doi.org/10.55484/ijpbp.1049943.
JAMA Sarkar S, Singh RP. Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis. Int. J. Plant Bas. Pharm. 2022;2:166–175.
MLA Sarkar, Subendu ve Rajender Pal Singh. “Nyctanthes Arbor-Tristis L.: Perspective of Phytochemical-Based Inhibition of Fatty Acid Biosynthesis in Mycobacterium Tuberculosis”. International Journal of Plant Based Pharmaceuticals, c. 2, sy. 2, 2022, ss. 166-75, doi:10.55484/ijpbp.1049943.
Vancouver Sarkar S, Singh RP. Nyctanthes arbor-tristis L.: Perspective of phytochemical-based inhibition of fatty acid biosynthesis in Mycobacterium tuberculosis. Int. J. Plant Bas. Pharm. 2022;2(2):166-75.