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İleri Glikasyon Son Ürünleri (AGE) ve Polikistik Over Sendromu İlişkisi

Yıl 2023, Cilt: 5 Sayı: 1, 8 - 17, 26.12.2023
https://doi.org/10.47769/izufbed.1318435

Öz

İleri glikasyon son ürünleri (AGE), arginin ve lizin gibi serbest amino asit grupları ile indirgen şekerlerin serbest karbonil grubu arasındaki enzimatik olmayan Maillard reaksiyonu yoluyla oluşan heterojen ve karmaşık bileşikler grubudur. Fizyolojik koşullarda tüm dokularda ve vücut sıvılarında AGE’ler oluşabilmektedir. Ekzojen olarak vücuda beslenme yoluyla da alınabilmektedir. Normal metabolizmanın bir parçası olarak vücutta oluşan AGE’ler dolaşımda yüksek düzeylere ulaştığında sağlık üzerinde olumsuz etkiler gösterebilmektedir. Bu olumsuz etkilerini; vücut proteinleri ile çapraz bağ yaparak veya hücre yüzey reseptörlerine bağlanarak göstermektedir. Bunun sonucu olarak; AGE’ler, oksidatif stres ve inflamasyonun gelişiminde rol oynayabilmektedir. AGE’ler; diyabet, insülin direnci, obezite, kardiyovasküler hastalıklar, nörodejeneratif hastalıklar, böbrek hastalıkları, infertilite ve polikistik over sendromu (PKOS) ile ilişkilendirilmiştir. PKOS’lu kadınlar; obezite, insülin direnci ve yumurtalık disfonksiyonuna sebep olan yüksek serum AGE düzeylerine sahiptir. AGE’lerin, vücutta hormonları inhibe etmesi, hormonları taklit etmesi, hormonların aşırı salınımına yol açması, oksidatif stres ve inflamasyona sebep olması ile PKOS’la ilişkili olabileceği düşünülmektedir. Güncel çalışmalar, diyet kaynaklı AGE’lerin (dAGE), PKOS’lu kadınlarda metabolik bozukluklara yol açabileceğini göstermektedir. PKOS semptomlarını yönetmek ve PKOS’la ilişkili hastalıkları önlemek amacıyla; diyet AGE içeriğinin azaltılmasının yeni bir tedavi yaklaşımı olabileceği öne sürülmektedir. Bu derlemede; AGE ve PKOS ilişkisinin güncel veriler eşliğinde değerlendirilmesi amaçlanmıştır.

Kaynakça

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Yıl 2023, Cilt: 5 Sayı: 1, 8 - 17, 26.12.2023
https://doi.org/10.47769/izufbed.1318435

Öz

Kaynakça

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  • Stinghen, A. E., Massy, Z. A., Vlassara, H., Striker, G. E., & Boullier, A. (2016). Uremic toxicity of advanced glycation end products in CKD. Journal of the American Society of Nephrology, 27(2), 354-370. DOI: 10.1681/ASN.2014101047.
  • Story M., Hayes M., Kalina B. Availability of foods in high schools: is there cause for concern? J Am Diet Assoc 1996;96:123-126. DOI: 10.1016/S0002-8223(96)00039-9.
  • Tantalaki, E., Piperi, C., Livadas, S., Kollias, A., Adamopoulos, C., Koulouri, A., ... & Diamanti-Kandarakis, E. (2014). Impact of dietary modification of advanced glycation end products (AGEs) on the hormonal and metabolic profile of women with polycystic ovary syndrome (PCOS). Hormones, 13(1), 65-73. DOI: 10.1007/BF03401321.
  • Tatone, C., Eichenlaub-Ritter, U., & Amicarelli, F. (2014). Dicarbonyl stress and glyoxalases in ovarian function. Biochemical Society Transactions, 42(2), 433-438. https://doi.org/10.1042/BST20140023.
  • Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., ... & Norman, R. J. (2018). Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Human reproduction, 33(9), 1602-1618. https://doi.org/10.1093/humrep/dey363.
  • Tessier F.J., Boulanger E., Howsam M. Metabolic transit of dietary advanced glycation end-products - the case of NƐ-carboxymethyllysine. Glycoconj J. 2021 Jun;38(3):311-317. doi: 10.1007/s10719-020-09950-y. Epub 2020 Sep 29. PMID: 32990827.
  • Thornalley, P. J., Langborg, A., & Minhas, H. S. (1999). Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochemical Journal, 344(1), 109-116. https://doi.org/10.1042/bj3440109.
  • Thornton, K., Merhi, Z., Jindal, S., Goldsammler, M., Charron, M. J., & Buyuk, E. (2020). Dietary Advanced Glycation End Products (AGEs) could alter ovarian function in mice. Molecular and cellular endocrinology, 510, 110826. https://doi.org/10.1016/j.mce.2020.110826.
  • Twarda-Clapa, A., Olczak, A., Białkowska, A. M., & Koziołkiewicz, M. (2022). Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells, 11(8), 1312. https://doi.org/10.3390/cells11081312.
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  • Vlassara, H., Cai, W., Goodman, S., Pyzik, R., Yong, A., Chen, X., ... & Uribarri, J. (2009). Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1. The Journal of Clinical Endocrinology & Metabolism, 94(11), 4483-4491. https://doi.org/10.1210/jc.2009-0089.
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  • Yalçın, E., & Rakıcıoğlu, N. (2022). Besinlerde Oluşan İleri Glikasyon Son Ürünlerine Polifenollerin Etkisi. Beslenme ve Diyet Dergisi, 50(2), 66-75. https://doi.org/10.33076/2022.BDD.1554.
  • Yamamoto, Y., & Yamamoto, H. (2013). RAGE-mediated inflammation, type 2 diabetes, and diabetic vascular complication. Frontiers in endocrinology, 4, 105. https://doi.org/10.3389/fendo.2013.00105.
  • Yaman, M., Demirci, M., Ede-Cintesun, E., Kurt, E., & Mızrak, Ö. F. (2022). Investigation of formation of well-known AGEs precursors in cookies using an in vitro simulated gastrointestinal digestive system. Food Chemistry, 373, 131451. https://doi.org/10.1016/j.foodchem.2021.131451.
  • Yılmaz, B., & Karabudak, E. (2016). Besinlerdeki ileri glikasyon son ürünleri ve azaltma yöntemleri. Beslenme ve Diyet Dergisi, 44(3), 280-288.
  • Yılmaz, B., & Karabudak, E. (2018). Diyet Kaynaklı İleri Glikasyon Son Ürünleri ve Sağlık Üzerine Etkileri. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, (4), 349-356. https://doi.org/10.31067/0.2018.55.
  • Yiğit, A., & Yıldız, M. (2022). Polikistik Over Sendromu ve Beslenme İlişkisi. SAĞLIK & BİLİM 2022: Beslenme-2, 147.
  • Zhu, J. L., Cai, Y. Q., Long, S. L., Chen, Z., & Mo, Z. C. (2020). The role of advanced glycation end products in human infertility. Life Sciences, 255, 117830. DOI: 10.1016/j.lfs.2020.117830.
  • Zhu, J. L., Chen, Z., Feng, W. J., Long, S. L., & Mo, Z. C. (2019). Sex hormone-binding globulin and polycystic ovary syndrome. Clinica chimica acta, 499, 142-148. DOI: 10.1016/j.cca.2019.09.010.
Toplam 97 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Beslenme Bilimi
Bölüm Makaleler
Yazarlar

Büşra Nur Aşık 0009-0005-0035-2828

Elif Ede Çintesun 0000-0001-6103-2784

Yayımlanma Tarihi 26 Aralık 2023
Gönderilme Tarihi 22 Haziran 2023
Kabul Tarihi 21 Ağustos 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 5 Sayı: 1

Kaynak Göster

APA Aşık, B. N., & Ede Çintesun, E. (2023). İleri Glikasyon Son Ürünleri (AGE) ve Polikistik Over Sendromu İlişkisi. İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 5(1), 8-17. https://doi.org/10.47769/izufbed.1318435

20503

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