Quantitative EEG Analysis in Patients with Mild Cognitive Impairment

Yıl 2025, Cilt: 12 Sayı: 2, 51 - 58, 31.08.2025

Süreyya Kumru

https://doi.org/10.32739/jnbs.12.2.2

Öz

Aim: The aim of this study was to compare the electrophysiological results of 25 patients with Alzheimer Disease (AD) and 30 patients with Mild Cognitive Impairment (MCI) with 25 age-, gender- and educationmatched Healthy Control (HC) subjects using spectral power analysis method. Materials and Methods: Resting EEG recordings were obtained with eyes closed for 4 minutes and with eyes open for 4 minutes. Electrode locations F3, Fz, F4, F7, F8, C3, Cz, C4, P3, Pz, P4, O1, O2, FP1, FP2 were preferred for analyses. Absolute power values of delta, theta, alpha, beta frequency bands were obtained after the preprocessing steps of the data by Fast Fourier Transform. Mann-Whitney U test was used for AD-MCI, AD-HC, MCIHC pairwise comparisons of alpha and theta channel measurements. Kruskal-Wallis test was used for triple comparisons of AD, MCI, HC. Results: In this study, consistent with previous published studies, an increase in theta power of FZ channels was observed in the AD participant group compared to the other participant groups (MCI and HC), with AD > MCI > HC. Conclusion: The absolute power values of the frequency bands with differences detected between the groups are sensitive in distinguishing MCI-AD cases for the theta power value in the FZ channel. This result reveals the importance of resting QEEG absolute power value analysis in diagnosing AD disease and detecting MCI at an early stage.

Anahtar Kelimeler

Mild Cognitive Impairment , Alzheimer , Resting EEG , QEEG

Kaynakça

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