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BAKLA (Vicia faba L.) KÖK UCU HÜCRELERİNDE NONİLFENOLÜN SİTOGENETİK ETKİLERİNİN İNCELENMESİ

Yıl 2023, Cilt: 2023 Sayı: 18, 40 - 52, 03.07.2023

Öz

Nonilfenoller insan ve hayvanlarda salgılanan bazı hormonların taklitçisi olarak iş gören kimyasal maddelerden biridir. Nonilfenoller günlük hayatta çamaşır, bulaşık deterjanı, antioksidan, çözündürücü, boya, böcek öldürücü, kişisel bakım ürünleri, bazı bebek bezlerinde, plastik üretiminde yoğun olarak kullanılmaktadır. Bu maddenin insan ve hayvanlardaki etkileri ile ilgili çok sayıda çalışma yapılmış fakat bitkiler üzerindeki sitogenetik etkileri ile ilgili yeterli çalışmaya rastlanmamıştır. Bu çalışmada nonilfenolün bakla (Vicia faba L.) tohumlarının çimlenmesi sırasında gerçekleşen mitoz bölünmesi üzerindeki etkileri ilk kez incelenmiştir. Kontrol, 25, 50 ve 100 ppm nonilfenol içeren çözeltilerle sulanan tüm bakla tohumları çimlenmiş fakat 200, 400, 800 ve 1000 ppm çözelti ile sulanan tohumlar çimlenmemiştir. Artan nonilfenol konsantrasyonu mitoz bölünmeyi olumsuz etkilemiştir. Nonilfenol, çimlenen tohumların kromozom ve çekirdeklerinde de anormallikler meydana getirmiştir. En çok gözlenen anormallik bir, iki ya da üç mikro çekirdek oluşumudur. Ayrıca düzensiz kromozom dağılması, kromozom yapışması, kromozom büzülmesi, köprü kromozom gibi kromozom anormallikleri de bu çalışmada gözlenmiştir. En çok anormallik çeşidi 50 ppm nonilfenol çözeltisi uygulanan tohumlarda, en az anormallik çeşidi ise 100 ppm nonilfenol çözeltisi uygulanan tohumlarda gözlenmiştir. Bu sonuçlar nonilfenolün sadece insan ve hayvanlarda değil bitkilerin mitoz bölünmesini de etkilediği ve kromozom anormallikleri yaptığını net olarak göstermiştir.

Kaynakça

  • Çetinkaya S (2009). Endokrin çevre bozucular ve ergenlik üzerine etkileri. Dicle Tıp Dergisi, Cilt 36(1), s. 59-66, Diyarbakır, Türkiye.
  • Durusoy R, Karababa AO (2011). Plastik gıda ambalajları ve sağlık. TAF Preventive Medicine Bulletin, Cilt 10(1), s. 87-96, Türkiye.
  • Toppari J, Larsen J, Christiansen P, Giwercman A, Grandjean P, Guillette Jr L, Jegou B, Jensen T, Jouannet P, Keiding N, Leffers H, Mclachlan J, Meyer O, Muller J, Rajpert-De-Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek N (1996). Male Reproductive Health and Environmental Xenoestrogens. Environ. Health Perspec., Vol. 104(4), s.741-803.
  • Forman D (1991). The Ames Test and the Causes of Cancer. Br. Med. J., Vol. 303, s. 428-429.
  • Balakrishnan B, Thorstensen E, Ponnampalam A, Mitchell MD (2011). Passage of 4-nonylphenol across the human placenta. Placenta, Vol. 32, s.788-792.
  • Jubendradass R, D’cruz SC, Rani SJA, Mathur PP (2012). Nonylphenol induces apoptosis via mitochondria- and Fas-L-mediated pathways in the liver of adult male rat. Regulatory Toxicology and Pharmacology, Vol. 62, s.405-411.
  • Vural N, Duygu Y (1992). Ankara Çayının Anyonik ve Noniyonik Yüzey Aktif Madde Kirliliğinin Araştırılması. Ankara Ecz. Fak. Der. Cilt 21, s.1-2 Ankara, Türkiye.
  • Muller S, Schmid P, Schlatter C (1998). Pharmacokinetic behavior of 4-nonylphenol in humans. Environmental Toxicology and Pharmacology, Vol. 5(4), s. 257-265.
  • Soares A, Guieysse B, Jefferson B, Cartmell E, Lester JN (2008). Nonylphenol in the environment: A critical review on occurrence, fate, toxicity and treatment in wastewaters. Environment International, Vol. 34, s.1033-1049.
  • Raecker T, Thiele B, Boehme RM, Guenther K (2011). Endocrine disrupting nonyl- and octylphenol in infant food in Germany: Considerable daily intake of nonylphenol for babies. Chemosphere, Vol. 82, s.1533-1540.
  • Diehl J, Johnson SE, Xia K, West A, Tomanek L (2012). The distribution of 4-nonylphenol in marine organisms of North American Pacific Coast estuaries. Chemosphere, Vol. 87, s. 490-497.
  • Kinnberg K, Korsgaard B, Bjerregaard P (2000). Concentration dependent effects of nonylphenol on testis structure in adult platyfish Xiphophorus maculatus. Marine Environmental Research, Vol. 50, s.169-173.
  • Sabbietia MG, Agas D, Palermo F, Mosconi G, Santoni G, Amantini C, Farfariello V, Marchettia L (2011). 4- Nonylphenol triggers apoptosis and affects 17-β-Estradiol receptors in calvarial osteoblasts. Toxicology, Vol. 290, s. 334-341.
  • Hossaini A, Dalgaard M, Vinggaard AM, Frandsen H, Larsen JJ (2001). In utero reproductive study in rats exposed to nonylphenol. Reproductive Toxicology, Vol.15, s.537-543.
  • Chang LL, Wunb WSA, Wang PS (2014). Recovery from developmental nonylphenol exposure is possible for female rats. Chemico-Biological Interaction, Vol.221, s. 52-60.
  • Laurenzana EM, Balasubramanian G, Weis C, Blaydes B, Newbold RR, Delclos KB (2002). Effect of nonylphenol on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal, and adult rats. Chemico-Biological Interactions, Vol.139, s. 23- 41.
  • Han XD, Tu ZG, Gong Y, Shen SN, Wang XY, Kang LN, Hou YY, Chen JX (2004). The toxic effects of nonylphenol on the reproductive system of male rats. Reproductive Toxicology, Vol.19, s. 215-221.
  • Xia YY, Zhan P, Wang Y (2008). Effects of Nonylphenol on Brain Gene Expression Profiles in F1 Generation Rats. Biomedical and Environmental Sciences, Vol.21, s.1-6.
  • Korkmaz A, Aydoğan M, Kolankaya D, Barlas N (2011). Vitamin C coadministration augments bisphenol A, nonylphenol, and octylphenol induced oxidative damage on kidney of rats. Environmental Toxicology, Vol.26(4), s. 325-337.
  • Aydoğan M, Korkmaz A, Barlas N, Kolankaya D (2010). Prooxidant effect of vitamin C coadministration with bisphenol A, nonylphenol, and octylphenol on the reproductive tract of male rats. Drug and Chemical Toxicology, Vol.33(2), s.193-203.
  • Jubendradass R, D'cruz SC, Mathur PP (2011). Short-term exposure to nonylphenol induces pancreatic oxidative stress and alters liver glucose metabolism in adult female rats. J Biochem Mol Toxicol., Vol. 25(2), s.77- 83.
  • Zhang H, Xue W, Li Y, Ma Y, Zhu Y, Huo W, Xu B, Xia W, Xu S (2014). Perinatal exposure to 4-nonylphenol affects adipogenesis in first and second generation rats offspring. Toxicology Letters, Vol.225, s.325-332.
  • Zemheri F (2015). Ratlarda kronik nonilfenol ve c vitamini uygulamasının gen ekspresyon düzeyine etkisi. (Doktora Tezi). Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü.
  • Çakmak G, Togan İ, Uğuz C, Severcan F (2003). FT-IR Spectroscopic Analysis of Rainbow Trout Liver Exposed to Nonylphenol, Appl. Spectrosc. Vol.57, s. 835-84.
  • Nice HE (2005). Sperm motility in the Pacific oyster (Crassostrea gigas) is affected by nonylphenol. Marine Pollution Bulletin Vol.50, s.1668-1674.
  • Lukac N, Lukacova J, Pinto B, Knazicka Z, Tvrda E, Massanyi P (2013). The effect of nonylphenol on the motility and viability of bovine spermatozoa in vitro. Journal of Environmental Science and Health, Part A Vol. 48, s. 973-979.
  • Roig B, Cadiere A, Bressieux S, Biau S, Faure S, Barbara P (2014). Environmental concentration of nonylphenol alters the development of urogenital and visceral organs in avian model. Environment International, Vol.62, s.78-85.
  • Uğuz C, Varışlı O, Ağca C, Ağca Y (2014). In vitro effects of nonylphenol on motility, mitochondrial, akrozomal and chromatin integrity of ram and boar spermatozoa, Andrologia, Vol. 47(8), s. 910-919.
  • Hense BA, Welzl G, Severin GF, Schrammc KW (2005). Nonylphenol induced changes in trophic web structure of plankton analysed by multivariate statistical approaches. Aquatic Toxicology, Vol.73, s. 190-209.
  • Ademollo N, Ferrara F, Delise M, Fabietti F, Funari E (2008). Nonylphenol and octylphenol in human breast milk. Environment International, Vol.34, s. 984-987.
  • Diana A, Dimitra V (2011). Alkylphenols and phthalates in bottled waters. Journal of Hazardous Material, Vol.185, s. 281-286.
  • Li X, Ying GG, Zhao JL, Chen ZF, Lai HJ, Su HC (2013). 4- Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels. Environment International, Vol.52, s. 81-86.
  • Dong Y,Wang J, Feng D, Qin H, Wen H, Yin Z, Gao G, Li C (2014). Protective Effect of Quercetin against Oxidative Stress and Brain Edema in an Experimental Rat Model of Subarachnoid Hemorrhage. Int. J. Med. Sci., Vol.11(3), s.282-290.
  • Wu M, Xu H, Shen Y, Qiu W, Yang M (2011). Oxidatıve Stress in Zebrafish Embryos Induced By Short-Term Exposure To Bisphenol A, Nonylphenol, and Their Mixture. Environmental Toxicology and Chemistry, Vol. 30(10), s. 2335-2341.
  • Boyacıoğlu M, Arslan Çakal Ö, Parlak H, Karaaslan M (2007). Mutagenicity of nonylphenol and octylphenol using salmonella mutation assay., E.Ü. Su Ürünleri Dergisi, E.U. Journal of Fisheries & Aquatic Sciences, Vol.24, (3-4), s. 299-302.
  • Yıldırım A, Bardakçı F, Karataş M, Tanyolaç B (2007) Moleküler Biyoloji. Nobel Yayın No: 1170, Ankara, Türkiye.
  • Ergün SS, Üstüner B, Alçay S, Sağırkaya H, Uğuz C (2014). The Effects of Nonylphenol on Gamete Physiology in Bovine. Journal of Applied Biological Sciences, Vol. 8(2), s.32-38.
  • Abdel Rahman AN, Mahmoud SM, Khamis T, Rasheed N, Mohamed DI, Ghanem R, Mansour DM, Ismail TA, Mahboub HH (2022). Palliative effect of dietary common sage leaves against toxic impacts of nonylphenol in Mirror carp (Cyprinus carpio var specularis): Growth, gene expression, immune-antioxidant status, and histopathological alterations. Aquaculture Reports, Vol.25.
  • Jiang L, Yang Y, Zhang Y, Liu Y, Pan B, Wang B, Lin Y (2019). Accumulation and toxicological effects of nonylphenol in tomato (Solanum lycopersicum L) plants. Scientific Reports, Vol. 9(1), s.1-9.
  • Jiang L, Wang B, Liang J, Pan B, Yang Y, Lin Y (2020). Reduced phytotoxicity of nonylphenol on tomato (Solanum lycopersicum L.) plants by earthworm casts, Environmental Pollution, Vol. 265.
  • Ke Z, Wang D, Wu Z (2022) Separate and combined effects of cadmium (Cd) and nonylphenol (NP) on growth and antioxidative enzymes in Hydrocharis dubia (Bl.) Backer. Environ Sci Pollut Res Vol. 29, s.78913–78925.
  • Hu Y, Wu W, Xu D, Guan X, Wang S (2021). Occurrence, uptake, and health risk assessment of nonylphenol in soil-celery system simulating long-term reclaimed water irrigation, Journal of Hazardous Materials,Vol. 406.
  • Darlington CD, La Cour LF (1976). The Handling of Chromosomes. Allen and Unwin.
  • İnceer H, Beyazoğlu O (2000). Bakır klorür’ün Vicia hirsuta (L.) S.F. Gray kök ucu hücreleri üzerine sitogenetik etkileri. Turk J Biol. Vol. 24, s.553–559.
  • Kıran Y, Şahin A (2005). The effects of the lead on the seed germination, root growth and root tip cell mitotic divisions of Lens culinaris Medik. GU J Sci. Vol.18(1), s.17–25.
  • Yi S, Wang RL, Feng T, Xiang YC, Zhou H (2007). Effects of uranium tailings lixivium on early growth of Vicia Faba. J Hunan Univ Sci Technol. Vol. 4, s.113–116.
  • Özdemir C, Ereeş FS, Çam S (2008). Cytogenetic effects of uranium on root tip cells of Vicia faba L. Bot Lithuan. Vol.14 (3) s.155–158.
  • Parween T, Jan S, Mahmooduzzafar Sharma MP, Mujib A, Fatma T (2011). Genotoxic impact of cadmium on root meristem of Vicia faba L. Russ Agric Sci. Vol. 37(2), p.115–119.
  • Özdemir A, Bozdağ B, Sepet H, Parlak Y, Kocabaş O, Ereeş FS, Özdemir C (2015) Cytogenetic effects of 99technetium on meristematic cells of root tips of Vicia faba L. and statistical comparison, Caryologia, Vol.68(3), s. 200-206.
  • Sepet H, Çanlı M, Özdemir A, Bozdağ B, Özdemir C (2014). Cytogenetic Effects Of 48Titanium (48Ti) On Meristematic Cells Of Root Tips Of Lens culinaris Med. Pak. J. Bot., Vol.46(1), s.101-110.
  • Alaca C, Özdemir A, Bozdağ B, Özdemir C (2020) Cytogenetic effects of C6H4 (CH3)2 (xylene) on meristematic cells of root tips of Vicia faba L. and mathematical analysis. Caryologia Vol. 73(1), s. 27-35
  • Hernandez RG, Zumbadoa M, Luzardo OP, Monterde JG, Blanco A, Boada LD (2007). Multigenerational study of the hepatic effects exerted by the consumption of nonylphenol- and 4-octylphenol contaminated drinking water in Sprague–Dawley rats. Environmental Toxicology and Pharmacology, Vol.23, s.73-81.
Yıl 2023, Cilt: 2023 Sayı: 18, 40 - 52, 03.07.2023

Öz

Kaynakça

  • Çetinkaya S (2009). Endokrin çevre bozucular ve ergenlik üzerine etkileri. Dicle Tıp Dergisi, Cilt 36(1), s. 59-66, Diyarbakır, Türkiye.
  • Durusoy R, Karababa AO (2011). Plastik gıda ambalajları ve sağlık. TAF Preventive Medicine Bulletin, Cilt 10(1), s. 87-96, Türkiye.
  • Toppari J, Larsen J, Christiansen P, Giwercman A, Grandjean P, Guillette Jr L, Jegou B, Jensen T, Jouannet P, Keiding N, Leffers H, Mclachlan J, Meyer O, Muller J, Rajpert-De-Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek N (1996). Male Reproductive Health and Environmental Xenoestrogens. Environ. Health Perspec., Vol. 104(4), s.741-803.
  • Forman D (1991). The Ames Test and the Causes of Cancer. Br. Med. J., Vol. 303, s. 428-429.
  • Balakrishnan B, Thorstensen E, Ponnampalam A, Mitchell MD (2011). Passage of 4-nonylphenol across the human placenta. Placenta, Vol. 32, s.788-792.
  • Jubendradass R, D’cruz SC, Rani SJA, Mathur PP (2012). Nonylphenol induces apoptosis via mitochondria- and Fas-L-mediated pathways in the liver of adult male rat. Regulatory Toxicology and Pharmacology, Vol. 62, s.405-411.
  • Vural N, Duygu Y (1992). Ankara Çayının Anyonik ve Noniyonik Yüzey Aktif Madde Kirliliğinin Araştırılması. Ankara Ecz. Fak. Der. Cilt 21, s.1-2 Ankara, Türkiye.
  • Muller S, Schmid P, Schlatter C (1998). Pharmacokinetic behavior of 4-nonylphenol in humans. Environmental Toxicology and Pharmacology, Vol. 5(4), s. 257-265.
  • Soares A, Guieysse B, Jefferson B, Cartmell E, Lester JN (2008). Nonylphenol in the environment: A critical review on occurrence, fate, toxicity and treatment in wastewaters. Environment International, Vol. 34, s.1033-1049.
  • Raecker T, Thiele B, Boehme RM, Guenther K (2011). Endocrine disrupting nonyl- and octylphenol in infant food in Germany: Considerable daily intake of nonylphenol for babies. Chemosphere, Vol. 82, s.1533-1540.
  • Diehl J, Johnson SE, Xia K, West A, Tomanek L (2012). The distribution of 4-nonylphenol in marine organisms of North American Pacific Coast estuaries. Chemosphere, Vol. 87, s. 490-497.
  • Kinnberg K, Korsgaard B, Bjerregaard P (2000). Concentration dependent effects of nonylphenol on testis structure in adult platyfish Xiphophorus maculatus. Marine Environmental Research, Vol. 50, s.169-173.
  • Sabbietia MG, Agas D, Palermo F, Mosconi G, Santoni G, Amantini C, Farfariello V, Marchettia L (2011). 4- Nonylphenol triggers apoptosis and affects 17-β-Estradiol receptors in calvarial osteoblasts. Toxicology, Vol. 290, s. 334-341.
  • Hossaini A, Dalgaard M, Vinggaard AM, Frandsen H, Larsen JJ (2001). In utero reproductive study in rats exposed to nonylphenol. Reproductive Toxicology, Vol.15, s.537-543.
  • Chang LL, Wunb WSA, Wang PS (2014). Recovery from developmental nonylphenol exposure is possible for female rats. Chemico-Biological Interaction, Vol.221, s. 52-60.
  • Laurenzana EM, Balasubramanian G, Weis C, Blaydes B, Newbold RR, Delclos KB (2002). Effect of nonylphenol on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal, and adult rats. Chemico-Biological Interactions, Vol.139, s. 23- 41.
  • Han XD, Tu ZG, Gong Y, Shen SN, Wang XY, Kang LN, Hou YY, Chen JX (2004). The toxic effects of nonylphenol on the reproductive system of male rats. Reproductive Toxicology, Vol.19, s. 215-221.
  • Xia YY, Zhan P, Wang Y (2008). Effects of Nonylphenol on Brain Gene Expression Profiles in F1 Generation Rats. Biomedical and Environmental Sciences, Vol.21, s.1-6.
  • Korkmaz A, Aydoğan M, Kolankaya D, Barlas N (2011). Vitamin C coadministration augments bisphenol A, nonylphenol, and octylphenol induced oxidative damage on kidney of rats. Environmental Toxicology, Vol.26(4), s. 325-337.
  • Aydoğan M, Korkmaz A, Barlas N, Kolankaya D (2010). Prooxidant effect of vitamin C coadministration with bisphenol A, nonylphenol, and octylphenol on the reproductive tract of male rats. Drug and Chemical Toxicology, Vol.33(2), s.193-203.
  • Jubendradass R, D'cruz SC, Mathur PP (2011). Short-term exposure to nonylphenol induces pancreatic oxidative stress and alters liver glucose metabolism in adult female rats. J Biochem Mol Toxicol., Vol. 25(2), s.77- 83.
  • Zhang H, Xue W, Li Y, Ma Y, Zhu Y, Huo W, Xu B, Xia W, Xu S (2014). Perinatal exposure to 4-nonylphenol affects adipogenesis in first and second generation rats offspring. Toxicology Letters, Vol.225, s.325-332.
  • Zemheri F (2015). Ratlarda kronik nonilfenol ve c vitamini uygulamasının gen ekspresyon düzeyine etkisi. (Doktora Tezi). Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü.
  • Çakmak G, Togan İ, Uğuz C, Severcan F (2003). FT-IR Spectroscopic Analysis of Rainbow Trout Liver Exposed to Nonylphenol, Appl. Spectrosc. Vol.57, s. 835-84.
  • Nice HE (2005). Sperm motility in the Pacific oyster (Crassostrea gigas) is affected by nonylphenol. Marine Pollution Bulletin Vol.50, s.1668-1674.
  • Lukac N, Lukacova J, Pinto B, Knazicka Z, Tvrda E, Massanyi P (2013). The effect of nonylphenol on the motility and viability of bovine spermatozoa in vitro. Journal of Environmental Science and Health, Part A Vol. 48, s. 973-979.
  • Roig B, Cadiere A, Bressieux S, Biau S, Faure S, Barbara P (2014). Environmental concentration of nonylphenol alters the development of urogenital and visceral organs in avian model. Environment International, Vol.62, s.78-85.
  • Uğuz C, Varışlı O, Ağca C, Ağca Y (2014). In vitro effects of nonylphenol on motility, mitochondrial, akrozomal and chromatin integrity of ram and boar spermatozoa, Andrologia, Vol. 47(8), s. 910-919.
  • Hense BA, Welzl G, Severin GF, Schrammc KW (2005). Nonylphenol induced changes in trophic web structure of plankton analysed by multivariate statistical approaches. Aquatic Toxicology, Vol.73, s. 190-209.
  • Ademollo N, Ferrara F, Delise M, Fabietti F, Funari E (2008). Nonylphenol and octylphenol in human breast milk. Environment International, Vol.34, s. 984-987.
  • Diana A, Dimitra V (2011). Alkylphenols and phthalates in bottled waters. Journal of Hazardous Material, Vol.185, s. 281-286.
  • Li X, Ying GG, Zhao JL, Chen ZF, Lai HJ, Su HC (2013). 4- Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels. Environment International, Vol.52, s. 81-86.
  • Dong Y,Wang J, Feng D, Qin H, Wen H, Yin Z, Gao G, Li C (2014). Protective Effect of Quercetin against Oxidative Stress and Brain Edema in an Experimental Rat Model of Subarachnoid Hemorrhage. Int. J. Med. Sci., Vol.11(3), s.282-290.
  • Wu M, Xu H, Shen Y, Qiu W, Yang M (2011). Oxidatıve Stress in Zebrafish Embryos Induced By Short-Term Exposure To Bisphenol A, Nonylphenol, and Their Mixture. Environmental Toxicology and Chemistry, Vol. 30(10), s. 2335-2341.
  • Boyacıoğlu M, Arslan Çakal Ö, Parlak H, Karaaslan M (2007). Mutagenicity of nonylphenol and octylphenol using salmonella mutation assay., E.Ü. Su Ürünleri Dergisi, E.U. Journal of Fisheries & Aquatic Sciences, Vol.24, (3-4), s. 299-302.
  • Yıldırım A, Bardakçı F, Karataş M, Tanyolaç B (2007) Moleküler Biyoloji. Nobel Yayın No: 1170, Ankara, Türkiye.
  • Ergün SS, Üstüner B, Alçay S, Sağırkaya H, Uğuz C (2014). The Effects of Nonylphenol on Gamete Physiology in Bovine. Journal of Applied Biological Sciences, Vol. 8(2), s.32-38.
  • Abdel Rahman AN, Mahmoud SM, Khamis T, Rasheed N, Mohamed DI, Ghanem R, Mansour DM, Ismail TA, Mahboub HH (2022). Palliative effect of dietary common sage leaves against toxic impacts of nonylphenol in Mirror carp (Cyprinus carpio var specularis): Growth, gene expression, immune-antioxidant status, and histopathological alterations. Aquaculture Reports, Vol.25.
  • Jiang L, Yang Y, Zhang Y, Liu Y, Pan B, Wang B, Lin Y (2019). Accumulation and toxicological effects of nonylphenol in tomato (Solanum lycopersicum L) plants. Scientific Reports, Vol. 9(1), s.1-9.
  • Jiang L, Wang B, Liang J, Pan B, Yang Y, Lin Y (2020). Reduced phytotoxicity of nonylphenol on tomato (Solanum lycopersicum L.) plants by earthworm casts, Environmental Pollution, Vol. 265.
  • Ke Z, Wang D, Wu Z (2022) Separate and combined effects of cadmium (Cd) and nonylphenol (NP) on growth and antioxidative enzymes in Hydrocharis dubia (Bl.) Backer. Environ Sci Pollut Res Vol. 29, s.78913–78925.
  • Hu Y, Wu W, Xu D, Guan X, Wang S (2021). Occurrence, uptake, and health risk assessment of nonylphenol in soil-celery system simulating long-term reclaimed water irrigation, Journal of Hazardous Materials,Vol. 406.
  • Darlington CD, La Cour LF (1976). The Handling of Chromosomes. Allen and Unwin.
  • İnceer H, Beyazoğlu O (2000). Bakır klorür’ün Vicia hirsuta (L.) S.F. Gray kök ucu hücreleri üzerine sitogenetik etkileri. Turk J Biol. Vol. 24, s.553–559.
  • Kıran Y, Şahin A (2005). The effects of the lead on the seed germination, root growth and root tip cell mitotic divisions of Lens culinaris Medik. GU J Sci. Vol.18(1), s.17–25.
  • Yi S, Wang RL, Feng T, Xiang YC, Zhou H (2007). Effects of uranium tailings lixivium on early growth of Vicia Faba. J Hunan Univ Sci Technol. Vol. 4, s.113–116.
  • Özdemir C, Ereeş FS, Çam S (2008). Cytogenetic effects of uranium on root tip cells of Vicia faba L. Bot Lithuan. Vol.14 (3) s.155–158.
  • Parween T, Jan S, Mahmooduzzafar Sharma MP, Mujib A, Fatma T (2011). Genotoxic impact of cadmium on root meristem of Vicia faba L. Russ Agric Sci. Vol. 37(2), p.115–119.
  • Özdemir A, Bozdağ B, Sepet H, Parlak Y, Kocabaş O, Ereeş FS, Özdemir C (2015) Cytogenetic effects of 99technetium on meristematic cells of root tips of Vicia faba L. and statistical comparison, Caryologia, Vol.68(3), s. 200-206.
  • Sepet H, Çanlı M, Özdemir A, Bozdağ B, Özdemir C (2014). Cytogenetic Effects Of 48Titanium (48Ti) On Meristematic Cells Of Root Tips Of Lens culinaris Med. Pak. J. Bot., Vol.46(1), s.101-110.
  • Alaca C, Özdemir A, Bozdağ B, Özdemir C (2020) Cytogenetic effects of C6H4 (CH3)2 (xylene) on meristematic cells of root tips of Vicia faba L. and mathematical analysis. Caryologia Vol. 73(1), s. 27-35
  • Hernandez RG, Zumbadoa M, Luzardo OP, Monterde JG, Blanco A, Boada LD (2007). Multigenerational study of the hepatic effects exerted by the consumption of nonylphenol- and 4-octylphenol contaminated drinking water in Sprague–Dawley rats. Environmental Toxicology and Pharmacology, Vol.23, s.73-81.
Toplam 52 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Mühendislik, Doku Mühendisliği
Bölüm Araştırma Makaleleri
Yazarlar

Bahattin Bozdağ 0000-0002-4466-3901

Canan Özdemir 0000-0003-1316-4146

Ali Özdemir 0000-0001-9330-7084

Yusuf Vural 0000-0003-3485-1914

Sema Vural 0009-0003-6216-1934

Erken Görünüm Tarihi 3 Temmuz 2023
Yayımlanma Tarihi 3 Temmuz 2023
Gönderilme Tarihi 15 Mart 2023
Kabul Tarihi 20 Haziran 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 2023 Sayı: 18

Kaynak Göster

APA Bozdağ, B., Özdemir, C., Özdemir, A., Vural, Y., vd. (2023). BAKLA (Vicia faba L.) KÖK UCU HÜCRELERİNDE NONİLFENOLÜN SİTOGENETİK ETKİLERİNİN İNCELENMESİ. Journal of New Results in Engineering and Natural Sciences, 2023(18), 40-52.