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Renin-Anjiyotensin-Aldosteron Sistemine Etkili Tıbbi Bitkilerin Potansiyel Kullanımı

Yıl 2022, Cilt: 3 Sayı: 1, 105 - 118, 27.04.2022

Öz

Renin-Anjiyotensin-Aldosteron sistemi (RAAS), kan basıncının, elektrolit dengesinin ve vasküler büyümenin düzenlenmesindeki önemi ile tanınmaktadır. RAAS’ın aşırı aktivasyonu koroner kalp hastalıkları, hipertansiyon, kronik böbrek yetmezliği, diyabet gibi morbidite ve mortalite oranları yüksek kronik hastalıkların gelişiminde önemli rol oynamaktadır. Bu aktivasyon ile ortaya çıkan hastalıklar yine RAAS bileşenlerinin anjiyotensin reseptör blokerleri (ARB) başta olmak üzere çeşitli basamaklarda farmakolojik ajanlar ile inhibe edilmesi ile yapılmaktadır. Öte yandan halk tıbbında yüzyıllardır pek çok bitki türünün geleneksel olarak hastalıkları tedavi edici etkilerinden ötürü kullanıldığı bilinmektedir. Günümüzde gelişen teknolojiler ile birlikte bitki türlerinin taşıdıkları fitobileşenlerin kimyasal yapıları aydınlatılmakta, biyolojik aktiviteleri ile ilişkileri anlaşılır hale gelmektedir. Hastalıkların tedavisinde kullanılan tıbbi bitki türlerinin incelenmesi yeni ilaç moleküllerinin keşfi ve geliştirilmesinde kilit rol oynayabilir. Bunun yanı sıra uygun şartlarda hazırlanmış standardize bitkisel preparatların hasta yaşam kalitesinin yükseltilmesi, kronik hastalıkların önlenmesi ve tedavilerinde destekleyici kullanımları farmakoekonomiye önemli faydalar sağlayabilir. Bu çalışma kronik hastalıkların gelişiminde kritik rol oynayan, RAAS aracılığı ile kardiyovasküler, solunum, endokrin ve üriner sistem üzerine etki ettikleri in vivo, in vitro ve klinik çalışmalar ile gösterilmiş 11 tıbbi bitki türü üzerinde yürütülen araştırma sonuçlarını derlemektedir. Seçilen bitki türleri Allium sp, Camelia sinensis, Nigella sativa, Olea europaea, Hibiscus sabdarffa, Curcuma longa, Crataegus sp, Rauwolfia serpentina, Rosmarinus officinalis, Crocus sativus ve Ephedra sinica olarak belirlenmiştir.

Kaynakça

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Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Geleneksel, Tamamlayıcı ve Bütünleştirici Tıp
Bölüm Derleme
Yazarlar

Tuba Serbetcı 0000-0002-9545-152X

Berfu Boğa 0000-0003-3565-6088

Yayımlanma Tarihi 27 Nisan 2022
Gönderilme Tarihi 1 Şubat 2022
Kabul Tarihi 11 Şubat 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 3 Sayı: 1

Kaynak Göster

APA Serbetcı, T., & Boğa, B. (2022). Renin-Anjiyotensin-Aldosteron Sistemine Etkili Tıbbi Bitkilerin Potansiyel Kullanımı. KTO Karatay Üniversitesi Sağlık Bilimleri Dergisi, 3(1), 105-118.