Is vitamin D deficiency frequently in patients with cirrhosis?

Yıl 2023, Cilt: 15 Sayı: 3, 83 - 87, 31.12.2023

Ahmet Uyanıkoğlu

https://doi.org/10.35514/mtd.2024.98

Öz

Aim: In this study, it was aimed to compare the frequency of vitamin D deficiency in compensated and decompensated cirrhotic patients with the control group.
Materials and Methods: Eighty patients and eighty control groups which have liver cirrhosis are included in this study. The diagnosis of cirrhosis are made by clinical, laboratory and imaging methods. Ascites, variceal bleeding, and elevated bilirubin were accepted as signs of decompensation.
Results: 46 of 80 cirrhotic patients are male (57.5%), the average age of the patient group is 54.40 ± 11.77 and the age distribution is 18-75. The control group consisted of 44 males (55%), average age of the control group is 53.85 ± 9.59, and age distribution is 18-75.
In patients with decompensated cirrhosis, the frequency of low vitamin D levels below 10 ng/ml was found to be statistically significantly more frequent compared to patients with compensated cirrhosis and the control group (p<0.05), while a higher vitamin D level above 30 ng/ml in decompensated cirrhosis compared to compensated cirrhosis and control group. significantly lower frequency (p<0.05).
There was no correlation between MELD score, Child score and vitamin D level in cirrhotic patients.
Conclusion: No correlation was found between Child stage, MELD score, and vitamin D levels. Vitamin D deficiency requiring replacement is more common in decompensated cirrhotic patients compared to compensated cirrhosis and control group.

Anahtar Kelimeler

cirrhosis, decompantation, D vitamin

Sirotik hastalarda D vitamini eksikliği sık mı?

Öz

Amaç: Bu çalışmada kompanse ve dekompanse sirotik hastalarda, D vitamin eksiklik sıklığının kontrol grubu ile karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Karaciğer sirozu olan 80 hasta ve 80 kontrol olgusu alınmıştır. Siroz tanısı klinik, laboratuvar ve görüntüleme yöntemleri ile konulmuştur. Asit, varis kanaması, bilirubin yüksekliği dekompansasyon bulguları olarak kabul edilmiştir.
Bulgular: Sirotik 80 hastanın, 46’sı erkek (%57,5), yaş ortalaması 54,40±11,77, yaş dağılımı 18-75, kontrol grubunun 44’ü erkek (%55), yaş ortalaması 53,85±9,59, yaş dağılımı 18-75 idi.
Dekompanse sirozlu hastalarda kompanse sirozlu hastalara ve kontrol grubuna göre 10 ng/ml altında vitamin D düzey düşüklük sıklığı istatistiki olarak anlamlı düzeyde daha sık saptanırken (p<0.05), 30 ng/ml üzerinde D vitamin düzey yüksekliği dekompanse sirozda kompanse siroz ve kontrol grubuna göre anlamlı düzeyde daha düşük sıklıkta saptanmıştır (p<0.05).
Sirotik hastalarda MELD skoru, CHILD skoru ile D vitamin düzeyi arasında korelasyon saptanmadı.
Sonuç: Child evresi, MELD skoru ile D vitamini düzeyi arasında korelasyon saptanmamıştır. Dekompanse sirotik hastalarda kompanse siroz ve kontrol grubuna göre replasman gerektirecek D vitamini eksikliği daha sıktır.

Anahtar Kelimeler

siroz, dekompansasyon, D vitamin

Kaynakça

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