The Role of cancer antigen 125 (Ca 125), Human Epididymis Protein 4 (HE4), Soluble Mezotelin Related Protein (SMRP), Folate Receptor Alpha (FOLRα) in Estimation of Malignancy Risk in Pelvic Masses

Yıl 2018, Cilt: 2 Sayı: 3, 208 - 216, 30.12.2018

Rabia Başer Açıkgöz Müge Harma

Öz

An
adnexal mass is a common gynecologic problem and malignancy must be excluded
for any mass that is not clearly benign. Since ovarian cancer is the most
common cause of gynecologic cancer death. The differential diagnosis of benign
and malignant neoplastic masses is important for referring the patient to the
gynecologic oncologist. Use of serum biomarkers for the diagnosis of ovarian
cancer is an active area of investigation. Our research was performed between
September 2014 and January 2017. Between 18 and 90 ages, 95 operated patients
because of pelvic masses are included. Preoperatively CA 125, HE4, SMRP, FOLRα
levels are measured for each patient and relationship between tumor marker
levels and pathological reports is examined. HE4 and SMRP levels are found
higher in malignant masses significantly. But CA 125 and FOLRα levels are not
related with malignancy. HE4 and
SMRP can be used as a serum biomarker for prediction of ovarian cancer
according to our study. However the data should be supported with more studies.

Anahtar Kelimeler

Pelvic Mass, Ca 125 Antigen, HE4 protein, SMRP protein, Folate Receptor alpha

Pelvik Kitlelerin Malignite Riski Değerlendirilmesinde Kanser Antijeni 125 (Ca 125), Human Epididymis Protein 4 (HE4), Soluble mesothelin-related protein (SMRP) ve Folat Reseptör Alfa (FOLRα) Ölçümünün Yeri

Öz

Adneksiyal
kitle yaygın jinekolojik sorundur ve kitleler için malignite net bir şekilde
dışlanmalıdır. Over kanserleri en mortal jinekolojik kanserlerdir. Benign ve
malign adneksiyal kitlelerin ayırıcı tanısı, hastanın jinekolojik onkologa
yönlendirilmesinde önemlidir. Over kanseri tanısında serum biyomarkerlarının
kullanılması yaygın olarak araştırılmaktadır. Çalışmamız Ekim 2014 – Ocak 2017
tarihleri arasında yapıldı. Pelvik kitlesi olan 18 ve 90 yaşları arasında 95
hasta seçildi. Her hasta için preooperatif CA 125, HE4, SMRP, FOLRα seviyeleri ölçüldü ve patoloji sonuçları ile kan
sonuçları arasındaki ilişki incelendi. HE4
ve SMRP malign kitlelerde önemli ölçüde yüksek bulundu. Fakat Ca 125 ve FOLRα
seviyeleri malingnitede anlamsız saptandı. Çalışmamıza göre; HE4 ve SMRP over
kanserini ön görmede kullanılabilir. Fakat daha fazla çalışmalar ile
desteklenmelidir.

Anahtar Kelimeler

Pelvik Kitle, Kanser Antijeni 125, HE4, SMRP, Folat Reseptör Alfa

Kaynakça

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