Jatropha gossypiifolia whole parts have been utilized in the management of several diseases such as anemia, and many others diseases. This study screened for the mineral composition, and in-vivo hematinic and antioxidant properties of J. gossypiifolia root n-hexane extract in Wistar rats. Standard protocols were used for the mineral constituents of J. gossypiifolia root. Forty-five male Wistar rats were randomly selected for this study. They were administered 40 mg/kg phenylhydrazine hydrochloride to induce-hemolytic anemia for 5 days and thereafter treated with graded oral doses of 30, 50, and 100 mg/kg J. gossypiifolia extract for 14 days. Hematological, antioxidant, peripheral blood smear, and histopathological evaluations of the blood cells and bone marrow were carried out. The results of the mineral composition of J. gossypiifolia physiological quantity include; calcium, potassium, sodium, chloride, manganese, iron, zinc, magnesium, and phosphorus. Calcium and magnesium were abundant at (33.14 and 8.34 mg/1kg) of the plant root. The results for the treatment groups at graded doses include; RBC at days 7 (4.68, 4.72, 4.82 x 106/ul) and 14 (6.51, 6.59, 6.82 x 106/ul), hematocrit at days 7 (40.30, 46.13, 48.63 %) and 14 (40.30, 41.47, 45.30%) and hemoglobin at days 7 (10.18, 10.92, 11.82 g/dl) and 14 (11.40, 11.87, 12.90 g/dl) when compared with untreated control (p<0.05). The peripheral blood smear showed normal blood morphology across the treatment groups when compared with untreated control rats. The histopathological architectural framework of the bone marrow elicited an excitatory effect of myeloid/erythroid cell ratio in the treatment groups when compared with phenylhydrazine control. J. gossypiifolia extract displayed hematinic potential, which concurred with its ethnomedicinal report.
Mineral constituents Hematinic Antioxidants Jatropha gossypiifolia
University of Benin
LS21009
Appreciate the effort of every contributor to this report
Mineral constituents Hematinic Antioxidants Jatropha gossypiifolia
LS21009
Birincil Dil | İngilizce |
---|---|
Konular | Sağlık Kurumları Yönetimi |
Bölüm | Research Article |
Yazarlar | |
Proje Numarası | LS21009 |
Erken Görünüm Tarihi | 6 Ekim 2023 |
Yayımlanma Tarihi | 30 Eylül 2023 |
Gönderilme Tarihi | 16 Aralık 2022 |
Kabul Tarihi | 27 Mart 2023 |
Yayımlandığı Sayı | Yıl 2023 Cilt: 40 Sayı: 3 |
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