The Etiological Role of Thyroid Dysfunction and Vitamin Deficiency in Patients with Telogen Effluvium

Yıl 2020, Cilt: 42 Sayı: 6, 705 - 709, 09.11.2020

Fevzi Sökmen

https://doi.org/10.20515/otd.775603

Öz

Aim: Telogen effluvium (TE) is one of the most common forms of non-scarring alopecia. This study aims to examine the proportion of vitamin B12 deficiency, vitamin D deficiency, iron deficiency, and thyroid dysfunction in patients with TE.
Materials and Methods: This retrospective observational study reviewed the records of 151 patients with TE who were admitted to our hospital from January 2016 to December 2019. The etiology of the patients' history information, medications, and laboratory findings were conducted. Ferritin, vitamin B12, vitamin D, TSH, sT4, sT3, thyroid autoantibodies (anti-TPO, anti-thyroglobulin, TSH receptor blocker antibody) of the patients were recorded.
Results: The median age of 151 patients was 29 (18 – 67). 22% of patients had vitamin B12 deficiency, 34% had a folic acid deficiency, 93.5% had vitamin D deficiency, and 68.5% had iron deficiency and 22.5% were anemic. While 117 (77.5%) of the women were premenopausal, 34 (22.5%) were postmenopausal. There were 23 (15.2%) patients with thyroid dysfunction, 2 had subclinical hyperthyroidism, 2 had hypothyroidism, and 19 had subclinical hypothyroidism.
Discussion and Conclusion: Study findings were obtained in our study that vitamin D and vitamin B12 deficiency, iron deficiency, and thyroid dysfunction may be associated with TE.

Anahtar Kelimeler

hyperthyroidism, hypothyroidism, iron defficiency, vitamin B12, vitamin D, telogen effluvium

Kaynakça

• 1. Rebora A. Telogen effluvium: a comprehensive review. Clin Cosmet Investig Dermatol. 2019;12:583.
• 2. Malkud S. Telogen Effluvium: A Review. J Clin Diagn Res. 2015;9:We01-3.
• 3. Daly T, Daly K. Telogen Effluvium With Dysesthesia (TED) Has Lower B12 Levels and May Respond to B12 Supplementation. J Drugs Dermatol. 2018;17:1236-40.
• 4. Seleit I, Bakry OA, Badr E, et al. Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study. Clin Cosmet Investig Dermatol. 2019;12:745.
• 5. Erkus E, Aktas G, Atak BM, et al. Haemogram parameters in vitamin D deficiency. J Coll Physicians Surg Pak. 2018;28:779-82.
• 6. Gerkowicz A, Chyl-Surdacka K, Krasowska D, et al. The role of vitamin D in non-scarring alopecia. Int J Mol Sci. 2017;18:2653.
• 7. Rasheed H, Mahgoub D, Hegazy R, et al. Serum ferritin and vitamin d in female hair loss: do they play a role? Skin Pharmacol Physiol. 2013;26:101-7.
• 8. Karadağ AS, Ertuğrul DT, Tutal E, et al. The role of anemia and vitamin D levels in acute and chronic telogen effluvium. Turkish Journal of Medical Sciences. 2011;41:827-33.
• 9. Alpdemir M, Alpdemir MF. Meta Analysis Vitamin D deficiency status in Turkey: A meta-analysis. Int J Med Biochem. 2019;2:118-31.
• 10. HERCBERGZ S. Low iron stores: a risk factor for excessive hair loss in non-menopausal women.
• 11. Rushton D. Nutritional factors and hair loss. Clin Dermatol. 2002;27:396-404.
• 12. Jamwal A, Sharma A, Rather P. Cutaneous manifestations of hypothyroidism: prospective hospital based clinical study. J Adv Med Dent Scie. 2013;1:5-12.
• 13. Poonia K, Thami GP, Bhalla M, et al. NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India. J Cosmet Dermatol. 2019;18:401-7.
• 14. Freinkel RK, Freinkel N. Hair growth and alopecia in hypothyroidism. Arch Dermatol. 1972;106:349-52.