Nobiletin’in nörodejeneratif hastalıklarda nöroprotektif etkilerine ilişkin güncel bir bakış

Yıl 2025, Cilt: 12 Sayı: 1, 160 - 166, 17.04.2025

İlknur Karakaya , Mustafa Saygın

Öz

Öz
Nobiletin, limon, portakal ve mandalina gibi turunçgillerin kabuğunda bulunan önemli biyolojik aktivitelere sahip bir flavonoid bileşiğidir. Nobiletin, antikanserojen, antienflamatuar, antiaterojenik, antiobezite antidiyabetik etkilerinden dolayı oldukça ilgi gören bir bileşiktir. Son yıllarda, nobiletinin santral sinir sistemi (SSS) üzerindeki potansiyel etkileri detaylı bir şeklide araştırılmış ve nöronal bozukluklardaki rolü oldukça ilgi çekici olmuştur. Yapılan çalışmalardan elde edilen sonuçlar; nobiletinin sinir sisteminde inflamatuar faktörlerin ekspresyonunu inhibe etmek, nörotoksik yanıtı azaltmak, antioksidan kapasiteyi artırmak, nöronların hücre ölümünü engellemek, akson büyümesini teşvik etmek, kan-beyin bariyeri geçirgenliğini azaltmak, beyin ödemini azaltmak, cAMP yanıt elemanı bağlayıcı protein ekspresyonunu (CREB) artırmak, hafızayı iyileştirmek ve antioksidatif stres kapasitesini iyileştirmek, enterik sinir sistemi, medulla spinalis ve siyatik sinir dejenerasyonunu engellemek gibi birçok biyolojik işlevlere sahip olduğunu göstermiştir. Günümüzde oldukça fazla sayıda bireyi etkileyerek küresel bir sağlık sorunu haline gelen Alzheimer ve Parkinson gibi nörodejeneratif hastalıklarda kullanılan mevcut tedavi yöntemleri ile kesin bir tedavisi bulunmamaktadır. Mevcut tedaviler bilişsel gerilemeyi iyileştirseler de hastalığın ilerlemesini önleyememekte, durduramamakta veya hastalığın neden olduğu etkiyi tersine çevirememektedir. Kan-beyin bariyerini geçebilen ve minimal veya hiç yan etkisi olmayan ilaçlar geliştirmek için klinik çalışmalar yapılmakta ve yapılmaya devam etmektedir. Nobiletin'in özellikle santral sinir sistemi (SSS) üzerindeki etkileri, Dünya’da en sık görülen ve mevcut tedavi modaliteleri ile prognozu tamamen değiştirilemeyen Alzheimer, Parkinson gibi nörodejeneratif hastalıklar başta olmak üzere birçok merkezi sinir sistemi hastalıkları ve bilişsel bozukluklarda tedaviye destek olma potansiyeli ile daha etkili tedavi ve protektif modalitelerin geliştirilmesini sağlayabilir.

Anahtar Kelimeler

Nobiletin, Santral Sinir Sistemi, Nöroprotektif, Nörodejeneratif

A current perspective on the neuroprotective effects of nobiletin in neurodegenerative diseases

Öz

Abstract
Nobiletin is a flavonoid compound with important biological activities found in the peel of citrus fruits such as lemon, orange and tangerine. Nobiletin is a compound that attracts a lot of attention due to its anticarcinogenic, anti-inflammatory, antiatherogenic, antiobesity and antidiabetic effects. In recent years, the potential effects of nobiletin on the central nervous system (CNS) have been investigated in detail and its role in neuronal disorders has been quite interesting. Results obtained from the studies carried out; nobiletin inhibits the expression of inflammatory factors in the nervous system, reduces the neurotoxic response, increases antioxidant capacity, inhibits cell death of neurons, promotes axon growth, reduces blood-brain barrier permeability, reduces brain edema, increases cAMP response element binding protein expression (CREB), improves memory. It has been shown that it has many biological functions such as healing and improving antioxidative stress capacity, preventing degeneration of the enteric nervous system, medulla spinalis and sciatic nerve. There is no definitive treatment for neurodegenerative diseases such as Alzheimer's and Parkinson's, which have become a global health problem by affecting a large number of individuals today. Although current treatments improve cognitive decline, they cannot prevent, stop, or reverse the disease's progression. Clinical studies have been and continue to be conducted to develop drugs that can cross the blood-brain barrier and have minimal or no side effects. The effects of Nobiletin, especially on the central nervous system (CNS), have the potential to support the treatment of many central nervous system diseases and cognitive disorders, especially neurodegenerative diseases such as Alzheimer's and Parkinson's, which are the most common in the world and whose prognosis cannot be completely changed with current treatment modalities. It can enable the development of effective treatment and protective modalities.

Anahtar Kelimeler

Nobiletin, Central Nervous System, Neuroprotective, Neurodegenerative

Kaynakça

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