2-Aminopiridin türevleri ile 2-metoksi-5-sülfamoyilbenzoik asit tuzlarının sentezi, karakterizasyonu, antimikrobiyal aktivitelerinin incelenmesi

Yıl 2023, Cilt: 49 Sayı: 2, 53 - 63, 30.10.2023

Halil İlkimen Cengiz Yenikaya Aysel Gülbandılar

https://doi.org/10.35238/sufefd.1315568

Öz

Bu çalışmada, 2-metoksi-5-sülfamoyilbenzoik asit (Hsba) ile 2-aminopiridin (ap), 2-benzilaminopiridin (2Bzap), 2-aminometilpiridin (2amp) ve 2-amino-3-hidroksipiridin (2a3OHp)’in proton transfer tuzları (2apsba, 2Bzapsba, 2ampsba ve 2a3OHpsba) sentezlenmiştir. Başlangıç maddeleri ve proton transfer tuzlarının Enterococcus faecalis (ATCC 29212), Listeria monocytogenes (ATCC 7644), Bacillus subtilis, Staphylococcus aureus (NRRL-B 767) (Gram pozitif), Escherichia coli (ATCC 25922) ve Pseudomonas aeruginosa (ATCC 27853) (Gram negatif) bakterilerine ve Candida Albicans (ATCC 14053) mayasına karşı antibakteriyel ve antifungal aktiviteleri incelenmiştir. Antifungal aktiviteler Flukonazol ile antibakteriyel aktiviteleri ise Sefepim, Vankomisin ve Levofloksasin ile kıyaslanmıştır. Deneyde kullanılan ve sentezlenen bileşikler bakteri ve mayalara karşı aktiviteye sahiptir. Bileşiklerin en iyi aktivite değerleri B. subtilis bakterisinde 2Bzap ve 2a3OHp (31,25 µg/mL), E. faecalis ve S. aureus bakterilerinde tüm bileşikler (Hsba hariç) (62,50 µg/mL), E. coli bakterisinde 2a3OHpsba (15,60 µg/mL), L. monocytogenes bakterisinde Hsba, 2Bzap, 2amp ve 2a3OHp (31,25 µg/mL), P. aeruginoa bakterisinde Hsba (31,25 µg/mL) ve C. albicans mayasında 2Bzap (31,25 µg/mL)’de gözlenmiştir.

Anahtar Kelimeler

2-Metoksi-5-sülfamoyilbenzoik asit, 2-Aminopiridin, Proton Transfer Tuzu, Antifungal aktivite, Antibakteriyel Aktivite

Destekleyen Kurum

Kütahya Dumlupınar Üniversitesi

Proje Numarası

2022/29

Teşekkür

Bu çalışma, Kütahya Dumlupınar Üniversitesi Bilimsel Araştırma Projeleri Komisyon’unca, 2022/29 numaralı proje olarak desteklenmiştir. Katkılarından dolayı Kütahya Dumlupınar Üniversitesi Bilimsel Araştırma Projeleri Komisyonu’na teşekkür ederiz.

Synthesis, characterization and investigation of antimicrobial activities of salts of 2-aminopyridine derivatives and 2-methoxy-5-sulfamoylbenzoic acid

Öz

In this study, proton transfer salts (2apsba, 2Bzapsba, 2ampsba and 2a3OHpsba) between 2-methoxy-5-sulfamoylbenzoic acid (Hsba) and 2-aminopyridine (ap), 2-benzylaminopyridine (2Bzap), 2-aminomethylpyridine (2amp) and 2-amino-3-hydroxypyridine (2a3OHp) were synthesized. Starting materials and proton transfer salts of Enterococcus faecalis (ATCC 29212), Listeria monocytogenes (ATCC 7644), Bacillus subtilis, Staphylococcus aureus (NRRL-B 767) (Gram positive), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) (Gram negative) bacteria and Candida Albicans (ATCC 14053) yeast of antibacterial and antifungal activities against were investigated. Antifungal activities were compared with Fluconazole and antibacterial activities with Cefepime, Vancomycin and Levofloxacin. The compounds used and synthesized in the experiment have activity against bacteria and yeasts. The best activity values of the compounds were observed 2Bzap and 2a3OHp (31.25 µg/mL) in B. subtilis bacteria, all compounds (except Hsba) (62.50 µg/mL) in E. faecalis and S. aureus bacteria, 2a3OHpsba (15.60 µg/mL) in E. coli bacteria, 2Bzapsba, Hsba, 2Bzap, 2amp and 2a3OHp (31.25 µg/mL) in L. monocytogenes bacteria, Hsba (31.25 µg/mL) in P. aeruginoa bacteria and 2Bzap (31.25 µg/mL) in C. albicans yeast.

Anahtar Kelimeler

2-Methoxy-5-sulfamoylbenzoic acid, 2-Aminopyridine, Proton Transfer Salt, Antifungal activity, Antibacterial activity.

Proje Numarası

2022/29

Kaynakça

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