Year 2018, Volume 12, Issue 2, Pages 65 - 70 2018-08-15

Castration induces progressive increase in the carotid intima-medial thickness of the male rat

Isaac Cheruiyot [1] , Beda Olabu [2] , Martin Kamau [3] , Kevin Ongeti [4] , Pamela Mandela [5]

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Objectives: The role of androgens in the development of cardiovascular diseases remains controversial. The current study

therefore aimed to determine the changes in the carotid intima-medial thickness of the male rat in surgically-induced hypogonadism.

Methods: Twenty-two Rattus norvegicus male rats aged two months were used. The rats were randomly assigned into baseline

(4), experimental (9) and control (9) groups. Hypogonadism was surgically induced in the experimental group by bilateral

orchiectomy under local anesthesia. At experiment weeks 3, 6 and 9, three rats from each group (experimental and control) were

euthanized, their common carotid artery harvested, and routine processing was done for paraffin embedding, sectioning and

staining. The photomicrographs were taken using a digital photomicroscope for morphometric analysis.

Results: The mean carotid intima-median thickness was 321.97 μm at baseline. There was a progressive increase in the carotid

intima-median thickness by 17.6%, 37% and 67.1% of the baseline values in the castrated group at the end of the third, sixth

and ninth week respectively (p<0.001). Although the carotid intima-median thickness increased in the non-castrated group with

increasing duration of the study, these increases were not statistically significant (p=0.110). The increase in carotid intima-median

thickness was associated with hyperplasia of the intimal layer as well as increased deposition of collagen fibers in the medial

layer.

Conclusion: Androgen deprivation by surgical castration induces a progressive increase in the carotid intima-median thickness.

This may constitute an anatomical basis for the higher predisposition of hypogonadal males to cardiovascular diseases.


androgens, carotid intima-medial thickness, castration, cardiovascular disease, hypogonadism
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Original Articles
Authors

Orcid: 0000-0002-1211-8247
Author: Isaac Cheruiyot (Primary Author)
Institution: Univesity of Nairobi
Country: Kenya


Author: Beda Olabu
Institution: Univesity of Nairobi
Country: Kenya


Author: Martin Kamau
Institution: University of Nairobi

Author: Kevin Ongeti
Institution: University of Nairobi

Author: Pamela Mandela
Institution: University of Nairobi

Dates

Publication Date: August 15, 2018

Bibtex @research article { anatomy422308, journal = {Anatomy}, issn = {1307-8798}, eissn = {1308-8459}, address = {Turkish Society of Anatomy and Clinical Anatomy (TSACA)}, year = {2018}, volume = {12}, pages = {65 - 70}, doi = {}, title = {Castration induces progressive increase in the carotid intima-medial thickness of the male rat}, key = {cite}, author = {Cheruiyot, Isaac and Olabu, Beda and Kamau, Martin and Ongeti, Kevin and Mandela, Pamela} }
APA Cheruiyot, I , Olabu, B , Kamau, M , Ongeti, K , Mandela, P . (2018). Castration induces progressive increase in the carotid intima-medial thickness of the male rat. Anatomy, 12 (2), 65-70. Retrieved from http://dergipark.org.tr/anatomy/issue/42272/422308
MLA Cheruiyot, I , Olabu, B , Kamau, M , Ongeti, K , Mandela, P . "Castration induces progressive increase in the carotid intima-medial thickness of the male rat". Anatomy 12 (2018): 65-70 <http://dergipark.org.tr/anatomy/issue/42272/422308>
Chicago Cheruiyot, I , Olabu, B , Kamau, M , Ongeti, K , Mandela, P . "Castration induces progressive increase in the carotid intima-medial thickness of the male rat". Anatomy 12 (2018): 65-70
RIS TY - JOUR T1 - Castration induces progressive increase in the carotid intima-medial thickness of the male rat AU - Isaac Cheruiyot , Beda Olabu , Martin Kamau , Kevin Ongeti , Pamela Mandela Y1 - 2018 PY - 2018 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 65 EP - 70 VL - 12 IS - 2 SN - 1307-8798-1308-8459 M3 - UR - Y2 - 2018 ER -
EndNote %0 Anatomy Castration induces progressive increase in the carotid intima-medial thickness of the male rat %A Isaac Cheruiyot , Beda Olabu , Martin Kamau , Kevin Ongeti , Pamela Mandela %T Castration induces progressive increase in the carotid intima-medial thickness of the male rat %D 2018 %J Anatomy %P 1307-8798-1308-8459 %V 12 %N 2 %R %U
ISNAD Cheruiyot, Isaac , Olabu, Beda , Kamau, Martin , Ongeti, Kevin , Mandela, Pamela . "Castration induces progressive increase in the carotid intima-medial thickness of the male rat". Anatomy 12 / 2 (August 2018): 65-70.
AMA Cheruiyot I , Olabu B , Kamau M , Ongeti K , Mandela P . Castration induces progressive increase in the carotid intima-medial thickness of the male rat. Anat. 2018; 12(2): 65-70.
Vancouver Cheruiyot I , Olabu B , Kamau M , Ongeti K , Mandela P . Castration induces progressive increase in the carotid intima-medial thickness of the male rat. Anatomy. 2018; 12(2): 70-65.