Year 2015, Volume 4, Issue 1, Pages 1 - 11 2016-01-12

SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS
BENZODİOKSOL HALKASI TAŞIYAN PİRAZOLİN TÜREVLERİNİN SENTEZİ VE YENİ ANTİMİKROBİYAL AJANLAR OLARAK DEĞERLENDİRİLMESİ

Mehlika Dilek ALTINTOP [1] , Belgin SEVER [2] , Ahmet ÖZDEMİR [3] , Zafer Asım KAPLANCIKLI [4]

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In the current work,new pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2-thienyl)-5-(3,4-methylenedioxyphenyl)-2-pyrazoline with sodium salts of N,N-disubstituted dithiocarbamic acids. The compounds were investigated for their inhibitory effects on pathogenic bacteria and yeasts using broth microdilution method. MTT assay was carried out to determine the cytotoxic effects of the compounds on NIH/3T3 mouse embryonic fibroblast cell line. Among the tested compounds, 1-[[(4-(4-fluorophenyl)piperazin-1-yl)thiocarbamoylthio]acetyl]-3-(2-thienyl)-5-(3,4-methylendioxyphenyl)-2-pyrazoline (2) was found to be the most promising antimicrobial agent due to its notable inhibitory effects on Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Candida parapsilosis when compared with the reference agents. Compound 2 did not cause any toxicity against NIH/3T3 cell line. This outcome pointed out that the antimicrobial activity of compound 2 was selective.

Bu çalışmada, 1-(kloroasetil)-3-(2-tiyenil)-5-(3,4-metilendioksifenil)-2-pirazolinin N,N-disübstitüe ditiyokarbamik asitler ile reaksiyonuyla yeni pirazolin türevleri sentezlendi. Bileşikler, broth mikrodilüsyon yöntemi kullanılarak patojenik bakterilere ve mayalara karşı inhibitör etkileri için araştırıldı. Bileşiklerin NIH/3T3 fare embriyonik fibroblast hücre dizisine karşı sitotoksik etkilerini saptamak için MTT deneyi gerçekleştirildi. Referans maddeler ile kıyaslandığında test edilen bileşikler arasında, 1-[[(4-(4-florofenil)piperazin-1-il)tiyokarbamoiltiyo]asetil]-3-(2-tiyenil)-5(3,4-metilendioksifenil)-2-pirazolin (2) Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli ve Candida parapsilosis mikroorganizmaları üzerindeki dikkate değer inhibitör etkilerine bağlı olarak en umut verici antimikrobiyal ajan olarak bulundu. Bileşik 2, NIH/3T3 hücre dizisine karşı herhangi bir toksisiteye neden olmadı. Bu sonuç, bileşik 2’nin antimikrobiyal etkisinin seçici olduğunu gösterdi
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Primary Language en
Journal Section Articles
Authors

Author: Mehlika Dilek ALTINTOP

Author: Belgin SEVER

Author: Ahmet ÖZDEMİR

Author: Zafer Asım KAPLANCIKLI

Bibtex @ { aubtdc237915, journal = {ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology}, issn = {2146-0264}, eissn = {2146-0213}, address = {Eskişehir Teknik Üniversitesi}, year = {2016}, volume = {4}, pages = {1 - 11}, doi = {10.18036/btdc.55522}, title = {SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS}, key = {cite}, author = {ALTINTOP, Mehlika Dilek and SEVER, Belgin and ÖZDEMİR, Ahmet and KAPLANCIKLI, Zafer Asım} }
APA ALTINTOP, M , SEVER, B , ÖZDEMİR, A , KAPLANCIKLI, Z . (2016). SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS. ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology, 4 (1), 1-11. Retrieved from http://dergipark.org.tr/aubtdc/issue/22140/237915
MLA ALTINTOP, M , SEVER, B , ÖZDEMİR, A , KAPLANCIKLI, Z . "SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS". ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology 4 (2016): 1-11 <http://dergipark.org.tr/aubtdc/issue/22140/237915>
Chicago ALTINTOP, M , SEVER, B , ÖZDEMİR, A , KAPLANCIKLI, Z . "SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS". ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology 4 (2016): 1-11
RIS TY - JOUR T1 - SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS AU - Mehlika Dilek ALTINTOP , Belgin SEVER , Ahmet ÖZDEMİR , Zafer Asım KAPLANCIKLI Y1 - 2016 PY - 2016 N1 - DO - T2 - ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology JF - Journal JO - JOR SP - 1 EP - 11 VL - 4 IS - 1 SN - 2146-0264-2146-0213 M3 - UR - Y2 - 2019 ER -
EndNote %0 ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS %A Mehlika Dilek ALTINTOP , Belgin SEVER , Ahmet ÖZDEMİR , Zafer Asım KAPLANCIKLI %T SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS %D 2016 %J ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology %P 2146-0264-2146-0213 %V 4 %N 1 %R %U
ISNAD ALTINTOP, Mehlika Dilek , SEVER, Belgin , ÖZDEMİR, Ahmet , KAPLANCIKLI, Zafer Asım . "SYNTHESIS AND EVALUATION OF BENZODIOXOLE APPENDED PYRAZOLINE DERIVATIVES AS NEW ANTIMICROBIAL AGENTS". ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology 4 / 1 (January 2016): 1-11.