Year 2018, Volume 2, Issue 2, Pages 53 - 68 2018-12-29

Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers

Nurulhünda Hancı [1] , Fehmi Odabasoglu [2] , Fadime Atalay Dumlu [3] , Ozlem Aydın Berktaş [4] , Zerrin Kutlu [5] , Mesut Halici [6] , Zekai Halici [7]

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Sesame oil (SO) is a component of the traditional health food in India as well as in oriental countries and has long been thought to possess the ability to prevent various diseases. We examined the protective effects of sesame oil against acute gastric mucosal damage induced in rats by nonsteroidal anti-inflammatory drug indomethacin (IND). We also intended to determine the relation between antiulcer effect of SO and its antioxidant properties by biochemical evaluation. In this study a total of 5 rat groups were used for ulcer experiment. Antiulcer effects of SO have been investigated on 24 hour fasted 5 rat groups with indomethacine (IND)-induced ulcer model in the presence of positive (Famotidine, FAM), negative (untreated IND group) and intact control groups. In ulcer experiments, two doses of SO exerted significant anti-ulcerogenic effects. In gastric tissues, sesame oil administration decreased the level of LPO and activities of CAT, GR, MPO which were increased after IND application. Furthermore, SO increased the level of GSH which decreased in ulcerous stomach tissues when compared to healthy rat group. We determined that SO has anti-ulcerative effect and this effect are related to antioxidative properties of sesame oil.

Sesame oil, Indomethacin, Gastroprotective effect, Myeloperoxidase, Vegetable oil
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Primary Language en
Subjects Food Science and Technology
Journal Section Article

Author: Nurulhünda Hancı
Country: Turkey

Author: Fehmi Odabasoglu (Primary Author)

Author: Fadime Atalay Dumlu
Country: Turkey

Author: Ozlem Aydın Berktaş
Country: Turkey

Author: Zerrin Kutlu
Country: Turkey

Author: Mesut Halici
Country: Turkey

Author: Zekai Halici
Country: Turkey

Bibtex @research article { ejfst477860, journal = {Eurasian Journal of Food Science and Technology}, issn = {}, address = {Rüveyda Mervenur BAĞDATLI}, year = {2018}, volume = {2}, pages = {53 - 68}, doi = {}, title = {Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers}, key = {cite}, author = {Hancı, Nurulhünda and Odabasoglu, Fehmi and Atalay Dumlu, Fadime and Aydın Berktaş, Ozlem and Kutlu, Zerrin and Halici, Mesut and Halici, Zekai} }
APA Hancı, N , Odabasoglu, F , Atalay Dumlu, F , Aydın Berktaş, O , Kutlu, Z , Halici, M , Halici, Z . (2018). Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers. Eurasian Journal of Food Science and Technology, 2 (2), 53-68. Retrieved from
MLA Hancı, N , Odabasoglu, F , Atalay Dumlu, F , Aydın Berktaş, O , Kutlu, Z , Halici, M , Halici, Z . "Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers". Eurasian Journal of Food Science and Technology 2 (2018): 53-68 <>
Chicago Hancı, N , Odabasoglu, F , Atalay Dumlu, F , Aydın Berktaş, O , Kutlu, Z , Halici, M , Halici, Z . "Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers". Eurasian Journal of Food Science and Technology 2 (2018): 53-68
RIS TY - JOUR T1 - Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers AU - Nurulhünda Hancı , Fehmi Odabasoglu , Fadime Atalay Dumlu , Ozlem Aydın Berktaş , Zerrin Kutlu , Mesut Halici , Zekai Halici Y1 - 2018 PY - 2018 N1 - DO - T2 - Eurasian Journal of Food Science and Technology JF - Journal JO - JOR SP - 53 EP - 68 VL - 2 IS - 2 SN - - M3 - UR - Y2 - 2019 ER -
EndNote %0 Eurasian Journal of Food Science and Technology Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers %A Nurulhünda Hancı , Fehmi Odabasoglu , Fadime Atalay Dumlu , Ozlem Aydın Berktaş , Zerrin Kutlu , Mesut Halici , Zekai Halici %T Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers %D 2018 %J Eurasian Journal of Food Science and Technology %P - %V 2 %N 2 %R %U
ISNAD Hancı, Nurulhünda , Odabasoglu, Fehmi , Atalay Dumlu, Fadime , Aydın Berktaş, Ozlem , Kutlu, Zerrin , Halici, Mesut , Halici, Zekai . "Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers". Eurasian Journal of Food Science and Technology 2 / 2 (December 2018): 53-68.