Year 2018, Volume 2, Issue 2, Pages 53 - 68 2018-12-29

Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers

Nurulhünda Hancı [1] , Fehmi Odabasoglu [2] , Fadime Atalay Dumlu [3] , Ozlem Aydın Berktaş [4] , Zerrin Kutlu [5] , Mesut Halici [6] , Zekai Halici [7]

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Sesame oil (SO) is a component of the traditional health food in India as well as in oriental countries and has long been thought to possess the ability to prevent various diseases. We examined the protective effects of sesame oil against acute gastric mucosal damage induced in rats by nonsteroidal anti-inflammatory drug indomethacin (IND). We also intended to determine the relation between antiulcer effect of SO and its antioxidant properties by biochemical evaluation. In this study a total of 5 rat groups were used for ulcer experiment. Antiulcer effects of SO have been investigated on 24 hour fasted 5 rat groups with indomethacine (IND)-induced ulcer model in the presence of positive (Famotidine, FAM), negative (untreated IND group) and intact control groups. In ulcer experiments, two doses of SO exerted significant anti-ulcerogenic effects. In gastric tissues, sesame oil administration decreased the level of LPO and activities of CAT, GR, MPO which were increased after IND application. Furthermore, SO increased the level of GSH which decreased in ulcerous stomach tissues when compared to healthy rat group. We determined that SO has anti-ulcerative effect and this effect are related to antioxidative properties of sesame oil.

Sesame oil, Indomethacin, Gastroprotective effect, Myeloperoxidase, Vegetable oil
  • Reference 1 Aebi, H. 1984. Catalase In Vitro, In: P. Lester (Ed.), Method. Enzymol. Academic Press. Pp. 121-126.
  • Reference 2 Aksakal, E., Akaras, N., Kurt, M., Tanboga, I.H., Halici, Z., Odabasoglu, F., Bakirci, E.M. And Unal, B. 2011. The Role of Oxidative Stress in Diabetic Cardiomyopathy: An Experimental Study. Eur. Rev. Med. Pharmacol. 15, 1241-1246.
  • Reference 3 Albayrak, F., Odabasoglu, F., Halici, Z., Polat, B., Dursun, H., Uyanik, A., Bayir, Y., Koc, F., Suleyman, H. And Albayrak, Y. 2010. The Role Of Erythropoietin In The Protection Of Gastric Mucosa From Indometacin-Induced Gastric Injury And Its Relationship With Oxidant And Antioxidant Parameters In Rats. J. Pharm. Pharmacol. 62, 85-90.
  • Reference 4 Atalay, F., Odabasoglu, F., Halici, M., Cadirci, E., Aydin-Berktas, O., Halici, Z. And Cakir, A. 2016. N-Acetyl Cysteine Has Both Gastro-Protective And Anti-Inflammatory Effects In Experimental Rat Models: Its Gastro-Protective Effect Is Related To Its In Vivo And In Vitro Antioxidant Properties. J. Cel. Biochem. 117, 308-319.
  • Reference 5 Atkuri, K.R., Mantovani, J.J., Herzenberg, L.A. And Herzenberg, L.A.2007. N-Acetylcysteine - A Safe Antidote For Cysteine/Glutathione Deficiency. Curr. Opin. Pharmacol. 7, 355-359.
  • Reference 6 Bradley, P.P., Priebat, D.A., Christensen, R.D. And Rothstein, G. 1982. Measurement Of Cutaneous Inflammation - Estimation of Neutrophil Content With an Enzyme Marker. J. Invest. Dermatol. 78, 206-209.
  • Reference 7 Care., C.C.O.A.1993. Guide To The Care And Use Of Experimental Animals, 2nd Ed. Ed. Bradda Printing Services Inc., Ottawa, On, Canada.
  • Reference 8 Cargile, J.L., Burrow, J.A., Kim, I., Cohen, N.D. And Merritt, A.M. 2004. Effect Of Dietary Corn Oil Supplementation On Equine Gastric Fluid Acid, Sodium, And Prostaglandin E-2 Content Before And During Pentagastrin Infusion. J. Vet. Intern. Med. 18, 545-549.
  • Reference 9 Carlberg, I. And Mannervik, B. 1985. Glutathione-Reductase. Method. Enzymol. 113, 484-490.
  • Reference 10 Carvalho, A.C.S., Guedes, M.M., De Souza, A.L., Trevisan, M.T.S., Lima, A.F., Santos, F.A. And Rao, V.S.N. 2007. Gastroprotective Effect Of Mangiferin, A Xanthonoid From Mangifera Indica, Against Gastric Injury Induced By Ethanol And Indomethacin In Rodents. Planta. Med. 73, 1372-1376.
  • Reference 11 Chandrasekaran, V.R.M., Hsu, D.Z. And Liu, M.Y. 2014. Beneficial Effect Of Sesame Oil On Heavy Metal Toxicity. Jpen-Parenter. Enter. 38, 179-185.
  • Reference 12 Chattopadhyay, I., Bandyopadhyay, U., Biswas, K., Maity, P. And Banerjee, R.K. 2006. Indomethacin Inactivates Gastric Peroxidase To Induce Reactive-Oxygen-Mediated Gastric Mucosal Injury And Curcumin Protects It By Preventing Peroxidase Inactivation And Scavenging Reactive Oxygen. Free. Radical. Bio. Med. 40, 1397-1408.
  • Reference 13 Chen, G., Kamal, M., Hannon, R. And Warner, T.D. 1998. Regulation Of Cyclo-Oxygenase Gene Expression In Rat Smooth Muscle Cells By Catalase. Biochem. Pharmacol. 55, 1621-1631.
  • Reference 14 Davies, K.J.A. 2000. Oxidative Stress, Antioxidant Defenses, And Damage Removal, Repair, And Replacement Systems. Iubmb. Life. 50, 279-289.
  • Reference 15 De La Lastra, Ca, B.M., Martin, M.J., Herrerias, J. And Motilva, V.2002. Extra Virgin Olive Oil Enriched Diets Reduce Indomethacin-Induced Gastric Oxidative Damage In Rats. Digest. Dis. Sci. 47, 2783-2790.
  • Reference 16 Demirci, N.B.E. And Nabil-Kamiloglu, N. 2011. Protective Effects Of The Vitamines A And E On The Smoking Induced Oxidative Damage In Portsmen. Kafkas. J. Med. Sci. 1, 109-113.
  • Reference 17 Elliott, S.N. And Wallace, J.L. 1997. Neutrophil-Mediated Gastrointestinal Injury. Canadian. J. Gastro.= Journal Canadien De Gastroenterologie 12, 559-568.
  • Reference 18 Halici, M., Kufrevioglu, O.I., Odabasoglu, F., Halici, Z., Cakir, A. And Aslan, A. 2011. The Ethanol–Water Extract Of Ramalina Capitata Has Gastroprotective And Antioxidative Properties: An Experimental Study In Rats With Indomethacin‐Induced Gastric Injuries. J. Food Biochem. 35, 11-26.
  • Reference 19 Hsseinigouzdagani, M., Geyikoglu, F., Colak, S., Turkez, H., Bakir, T.O. And Bakir, M. 2014. The Efficacy Of Carvacrol On Renal Damage In Rats With Acute Pancreatitis. J. Essent. Oil. Bear. Pl. 17, 847-858.
  • Reference 20 Hsu, D.Z., Chen, Y.W., Chu, P.Y., Periasamy, S. And Liu, M.Y. 2013a. Protective Effect Of 3,4-Methylenedioxyphenol (Sesamol) On Stress-Related Mucosal Disease In Rats. Biomed. Res. Int.
  • Reference 21 Hsu, D.Z., Chu, P.Y., Chandrasekaran, V.R.M. And Liu, M.Y. 2009a. Sesame Lignan Sesamol Protects Against Aspirin-Induced Gastric Mucosal Damage In Rats. J. Funct. Foods. 1, 349-355.
  • Reference 22 Hsu, D.Z., Chu, P.Y., Li, Y.H. And Liu, M.Y. 2008. Sesamol Attenuates Diclofenac-Induced Acute Gastric Mucosal Injury Via Its Cyclooxygenase-In Dependent Antioxidative Effect In Rats. Shock. 30, 456-462.
  • Reference 23 Hsu, D.Z., Chu, P.Y., Liu, M.Y., 2009b. Effect Of Sesame Oil On Acidified Ethanol-Induced Gastric Mucosal Injury In Rats. Jpen-Parenter Enter 33, 423-427.
  • Reference 24 Hsu Dz, C.P., Liu My. , 2011. Extracts Of Sesame (Sesamum Indicum L.) Seeds And Gastric Mucosal Cytoprotection. .
  • Reference 25 Hsu, D.Z., Liu, C.T., Chu, P.Y., Li, Y.H., Periasamy, S. And Liu, M.Y.2013b. Sesame Oil Attenuates Ovalbumin-Induced Pulmonary Edema And Bronchial Neutrophilic Inflammation In Mice. Biomed. Res. Int.
  • Reference 26 Hsu, D.Z., Su, S.B., Chien, S.P., Chiang, P.J., Li, Y.H., Lo, Y.J. And Liu, M.Y. 2005. Effect Of Sesame Oil On Oxidative-Stress-Associated Renal Injury In Endotoxemic Rats: Involvement Of Nitric Oxide And Proinflammatory Cytokines. Shock. 24, 276-280.
  • Reference 27 Ingold, K.U., Webb, A.C., Witter, D., Burton, G.W., Metcalfe, T.A. And Muller, D.P.R. 1987. Vitamin-E Remains The Major Lipid-Soluble, Chain-Breaking Antioxidant In Human-Plasma Even In Individuals Suffering Severe Vitamin-E-Deficiency. Arch. Biochem. Biophys. 259, 224-225.
  • Reference 28 Kaplan, K.A., Odabasoglu, F., Halici, Z., Halici, M., Cadirci, E., Atalay, F., Aydin, O. And Cakir, A.2012. Alpha‐Lipoic Acid Protects Against Indomethacin‐Induced Gastric Oxidative Toxicity By Modulating Antioxidant System. J. Food. Sci. 77, H224-H230.
  • Reference 29 Karaca, M., Odabasoglu, F., Kumtepe, Y., Albayrak, A., Cadirci, E. And Keles, O.N. 2009. Protective Effects Of Erythropoietin On Ischemia/Reperfusion Injury Of Rat Ovary. Eur. J. Obstet. Gyn. R B. 144, 157-162.
  • Reference 30 Karaca T, B.F., Cemek M, Comba B, Ayaz A, And Karaboga. 2013. Effects Of Green Tea Extract And Lactobacillus Casei Strain Shirota On Levels Of Serum Minerals, Cholesterol, Triglycerides, Glucose And Lactate In Rats Fed On High-Carbohydrate And High-Lipid Diets. Kafkas. J. Med. Sci. 3, 1-7.
  • Reference 31 Karakus, B., Odabasoglu, F., Cakir, A., Halici, Z., Bayir, Y., Halici, M., Aslan, A. And Suleyman, H. 2009. The Effects Of Methanol Extract Of Lobaria Pulmonaria, A Lichen Species, On Indometacin‐Induced Gastric Mucosal Damage, Oxidative Stress And Neutrophil Infiltration. Phytotherap. Res. 23, 635-639.
  • Reference 32 Khattab, M.M., Gad, M.Z. And Abdallah, D. 2001. Protective Role Of Nitric Oxide In Indomethacin-Induced Gastric Ulceration By A Mechanism Independent Of Gastric Acid Secretion. Pharmacol. Res. 43, 463-467.
  • Reference 33 Khier Mkse, I.K. And Yagoub Aega. 2008. Chemical Composition And Oil Characteristics Of Sesame Seed Cultivars Grown In Sudan Research. J. Agric. Biol. Sci. 4, 761-766.
  • Reference 34 Koc, M., Imik, H. And Odabasoglu, F. 2008. Gastroprotective And Anti-Oxidative Properties Of Ascorbic Acid On Indomethacin-Induced Gastric Injuries In Rats. Biol. Trace. Element. Res. 126, 222-236.
  • Reference 35 Kumtepe, Y., Odabasoglu, F., Karaca, M., Polat, B., Halici, M.B., Keles, O.N., Altunkaynak, Z. And Gocer, F. 2010. Protective Effects Of Telmisartan On Ischemia/Reperfusion Injury Of Rat Ovary: Biochemical And Histopathologic Evaluation. Fertil. Steril. 93, 1299-1307.
  • Reference 36 Mahadik, S.P. And Scheffer, R.E.1996. Oxidative Injury And Potential Use Of Antioxidants In Schizophrenia. Prostag. Leukotr. Ess. 55, 45-54.
  • Reference 37 Mates, J.M., Perez-Gomez, C. And De Castro, I.N. 1999. Antioxidant Enzymes And Human Diseases. Clin. Biochem. 32, 595-603.
  • Reference 38 Matheson, N.R., Wong, P.S. And Travis, J. 1981. Isolation And Properties Of Human Neutrophil Myeloperoxidase. Biochem.-Us 20, 325-330.
  • Reference 39 Miura, T., Muraoka, S. And Fujimoto, Y. 2002. Lipid Peroxidation Induced By Indomethacin With Horseradish Peroxidase And Hydrogen Peroxide: Involvement Of Indomethacin Radicals. Biochem. Pharmacol. 63, 2069-2074.
  • Reference 40 Mizoguchi, H., Ogawa, Y., Kanatsu, K., Tanaka, A., Kato, S. And Takeuchi, K. 2001. Protective Effect Of Rebamipide On Indomethacin‐Induced Intestinal Damage In Rats. J. Gastro. Hepato. 16, 1112-1119.
  • Reference 41 Muthuraman A, S.S. 2010. Antisecretory, Antioxidative And Antiapoptotic Effects Of Montelukast On Pyloric Ligation And Water Immersion Stress Induced Peptic Ulcer In Rat. Prostag. Leukotr. Ess. Fatty. Acids. 83, 55-60.
  • Reference 42 Namiki, M. 1995. The Chemistry And Physiological Functions Of Sesame. Food. Rev. Int. 11, 281-329.
  • Reference 43 Narasimhulu, C.A., Selvarajan, K., Litvinov, D. And Parthasarathy, S. 2015. Anti-Atherosclerotic And Anti-Inflammatory Actions Of Sesame Oil. J. Med. Food. 18, 11-20.
  • Reference 44 Niki, E., Tsuchiya, J., Tanimura, R. And Kamiya, Y. 1982. Regeneration Of Vitamin-E From Alpha-Chromanoxyl Radical By Glutathione And Vitamin-C. Chem. Lett. 789-792.
  • Reference 45 Nishida, K., Ohta, Y., Kobayashi, T. And Ishiguro, I. 1997. Involvement Of The Xanthine-Xanthine Oxidase System And Neutrophils In The Development Of Acute Gastric Mucosal Lesions In Rats With Water Immersion Restraint Stress. Digestion. 58, 340-351.
  • Reference 46 Odabasoglu, F., Halici, Z., Cakir, A., Halici, M., Aygun, H., Suleyman, H., Cadirci, E. And Atalay, F. 2008. Beneficial Effects Of Vegetable Oils (Corn, Olive And Sunflower Oils) And Α-Tocopherol On Anti-Inflammatory And Gastrointestinal Profiles Of Indomethacin In Rats. Eur. J. Pharm. 591, 300-306.
  • Reference 47 Odabasoglu, F., Yildirim, O.S., Aygun, H., Halici, Z., Halici, M., Erdogan, F., Cadirci, E., Cakir, A., Okumus, Z., Aksakal, B., Aslan, A., Unal, D. And Bayir, Y. 2012. Diffractaic Acid, A Novel Proapoptotic Agent, Induces With Olive Oil Both Apoptosis And Antioxidative Systems In Ti-Implanted Rabbits. Eur. J. Pharm. 674, 171-178.
  • Reference 48 Ohkawa, H., Ohishi, N. And Yagi, K. 1979. Assay For Lipid Peroxides In Animal Tissues By Thiobarbituric Acid Reaction. Anal. Biochem. 95, 351-358.
  • Reference 49 Oral, A., Odabasoglu, F., Halici, Z., Keles, O.N., Unal, B., Coskun, A.K., Kilic, C., Surer, I. And Salman, A.B. 2011. Protective Effects Of Montelukast On Ischemia-Reperfusion Injury In Rat Ovaries Subjected To Torsion And Detorsion: Biochemical And Histopathologic Evaluation. Fertil. Steril. 95, 1360-1366.
  • Reference 50 Periasamy, S., Hsu, D.Z., Chandrasekaran, V.R.M. And Liu, M.Y. 2013. Sesame Oil Accelerates Healing Of 2,4,6-Trinitrobenzenesulfonic Acid-Induced Acute Colitis By Attenuating Inflammation And Fibrosis. Jpen. Parenter. Enter. 37, 674-682.
  • Reference 51 Periasamy, S., Liu, C.T., Hsu, D.Z. And Liu, M.Y. 2010. Sesame Oil Accelerates Kidney Healing Following Gentamicin-Induced Kidney Injury In Rats. Am. J. Nephrol. 32, 383-392.
  • Reference 52 Polat, B., Albayrak, Y., Suleyman, B., Dursun, H., Odabasoglu, F., Yigiter, M., Halici, Z. And Suleyman, H. 2011. Antiulcerative Effect Of Dexmedetomidine On Indomethacin-Induced Gastric Ulcer In Rats. Pharm. Report. 63, 518-526.
  • Reference 53 Potrich, F.B., Allemand, A., Da Silva, L.M., Dos Santos, A.C., Baggio, C.H., Freitas, C.S., Mendes, D.A.G.B., Andre, E., Werner, M.F.D. And Marques, M.C.A. 2010. Antiulcerogenic Activity Of Hydroalcoholic Extract Of Achillea Millefolium L.: Involvement Of The Antioxidant System. J. Ethnopharm. 130, 85-92.
  • Reference 54 Pourahmad, J., Eskandari, M.R., Shakibaei, R. And Kamalinejad, M.,2010. A Search For Hepatoprotective Activity Of Aqueous Extract Of Rhus Coriaria L. Against Oxidative Stress Cytotoxicity. Food. Chem. Toxicol. 48, 854-858.
  • Reference 55 Saleem, T.S.M., Chetty, C.M. And Kavimani, S. 2012. Sesame Oil Enhances Endogenous Antioxidants In Ischemic Myocardium Of Rat. Rev. Bras. Farmacogn. 22, 669-675.
  • Reference 56 Sankar, D., Sambandam, G., Rao, M.R. And Pugalendi, K.V. 2005. Modulation Of Blood Pressure, Lipid Profiles And Redox Status In Hypertensive Patients Taking Different Edible Oils. Clin. Chim. Acta. 355, 97-104.
  • Reference 57 Sedlak, J.F. And Lindsay, R.H. 1968. Estimation Of Total, Protein-Bound, And Nonprotein Sulfhydryl Groups In Tissue With Ellman's Reagent. Anal.Biochem. 25, 192-205.
  • Reference 58 Shacter, E., Lopez, R.L. And Pati, S. 1991. Inhibition Of The Myeloperoxidase-H2o2-Cl- System Of Neutrophils By Indomethacin And Other Nonsteroidal Antiinflammatory Drugs. Biochem. Pharmacol. 41, 975-984.
  • Reference 59 Suleyman, B., Halici, Z., Odabasoglu, F. And Gocer, F. 2012. The Effect Of Lacidipine On Indomethacin Induced Ulcers In Rats. Int. J. Pharmacol. 8, 115-121.
  • Reference 60 Takeuchi, K., Yasuhiro, T., Asada, Y. And Sugawa, Y. 1998. Role Of Nitric Oxide In Pathogenesis Of Aspirin-Induced Gastric Mucosal Damage In Rats. Digestion. 59, 298-307.
  • Reference 61 Tanas, S., Odabasoglu, F., Halici, Z., Cakir, A., Aygun, H., Aslan, A., Suleyman, H., 2010. Evaluation Of Anti-Inflammatory And Antioxidant Activities Of Peltigera Rufescens Lichen Species In Acute And Chronic Inflammation Models. J. Natur. Med. 64, 42-49.
  • Reference 62 Turkez, H., Sozio, P., Geyikoglu, F., Tatar, A., Hacimuftuoglu, A. And Di Stefano, A. 2014. Neuroprotective Effects Of Farnesene Against Hydrogen Peroxide-Induced Neurotoxicity In Vitro. Cell. Mol. Neurobiol. 34, 101-111.
  • Reference 63 Uzkeser, H., Cadirci, E., Halici, Z., Odabasoglu, F., Polat, B., Yuksel, T.N., Ozaltin, S. And Atalay, F. 2012. Anti-Inflammatory And Antinociceptive Effects Of Salbutamol On Acute And Chronic Models Of Inflammation In Rats: Involvement Of An Antioxidant Mechanism. Mediat. Inflamm.
  • Reference 64 Wagner, K.A., Nandi, J., Levine, R.A. And King, R.L. 1995. Effects Of Nonsteroidal Antiinflammatory Drugs On Ulcerogenesis And Gastric-Secretion In Pylorus-Ligated Rat. Digest. Dis. Sci. 40, 134-140.
  • Reference 65 Wallace, J.L. And Granger, D.N. 1992. Pathogenesis Of Nsaid Gastropathy: Are Neutrophils The Culprits? Trends. Pharmacol. Sci. 13, 129-131.
  • Reference 66 Wallace, J.L., Mcknight, W., Reuter, B.K. And Vergnolle, N. 2000. Nsaid-Induced Gastric Damage In Rats: Requirement For Inhibition Of Both Cyclooxygenase 1 And 2. Gastroenterology 119, 706-714.
  • Reference 67 Weiss, S. And Lobuglio, A. 1982. Phagocyte-Generated Oxygen Metabolites And Cellular Injury. Laboratory Investigation; A Journal Of Technical Methods And Pathology 47, 5-18.
  • Reference 68 Whittle, B.J.R. 1981. Temporal Relationship Between Cyclooxygenase Inhibition, As Measured By Prostacyclin Biosynthesis, And The Gastrointestinal Damage Induced By Indomethacin In The Rat. Gastroenterology 80, 94-98.
  • Reference 69 Yadav, S.K., Adhikary, B., Bandyopadhyay, S.K. And Chattopadhyay, S. 2013. Inhibition Of Tnf-Alpha, And Nf-Kappa B And Jnk Pathways Accounts For The Prophylactic Action Of The Natural Phenolic, Allylpyrocatechol Against Indomethacin Gastropathy. Bba-Gen Subjects 1830, 3776-3786.
  • Reference 70 Yoshikawa, T., Naito, Y., Kishi, A., Tomii, T., Kaneko, T., Iinuma, S., Ichikawa, H., Yasuda, M., Takahashi, S. And Kondo, M. 1993. Role Of Active Oxygen, Lipid Peroxidation, And Antioxidants In The Pathogenesis Of Gastric Mucosal Injury Induced By Indomethacin In Rats. Gut. 34, 732-737.
Primary Language en
Subjects Food Science and Technology
Journal Section Article
Authors

Author: Nurulhünda Hancı
Institution: ATATÜRK ÜNİVERSİTESİ
Country: Turkey


Author: Fehmi Odabasoglu (Primary Author)
Institution: KAFKAS ÜNİVERSİTESİ

Author: Fadime Atalay Dumlu
Institution: KAFKAS ÜNİVERSİTESİ
Country: Turkey


Author: Ozlem Aydın Berktaş
Institution: GİRESUN ÜNİVERSİTESİ
Country: Turkey


Author: Zerrin Kutlu
Institution: ATATURK UNIVERSITY
Country: Turkey


Author: Mesut Halici
Institution: ATATÜRK ÜNİVERSİTESİ
Country: Turkey


Author: Zekai Halici
Institution: ATATÜRK ÜNİVERSİTESİ
Country: Turkey


Bibtex @research article { ejfst477860, journal = {Eurasian Journal of Food Science and Technology}, issn = {}, address = {Rüveyda Mervenur BAĞDATLI}, year = {2018}, volume = {2}, pages = {53 - 68}, doi = {}, title = {Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers}, key = {cite}, author = {Hancı, Nurulhünda and Odabasoglu, Fehmi and Atalay Dumlu, Fadime and Aydın Berktaş, Ozlem and Kutlu, Zerrin and Halici, Mesut and Halici, Zekai} }
APA Hancı, N , Odabasoglu, F , Atalay Dumlu, F , Aydın Berktaş, O , Kutlu, Z , Halici, M , Halici, Z . (2018). Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers. Eurasian Journal of Food Science and Technology, 2 (2), 53-68. Retrieved from http://dergipark.org.tr/ejfst/issue/42688/477860
MLA Hancı, N , Odabasoglu, F , Atalay Dumlu, F , Aydın Berktaş, O , Kutlu, Z , Halici, M , Halici, Z . "Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers". Eurasian Journal of Food Science and Technology 2 (2018): 53-68 <http://dergipark.org.tr/ejfst/issue/42688/477860>
Chicago Hancı, N , Odabasoglu, F , Atalay Dumlu, F , Aydın Berktaş, O , Kutlu, Z , Halici, M , Halici, Z . "Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers". Eurasian Journal of Food Science and Technology 2 (2018): 53-68
RIS TY - JOUR T1 - Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers AU - Nurulhünda Hancı , Fehmi Odabasoglu , Fadime Atalay Dumlu , Ozlem Aydın Berktaş , Zerrin Kutlu , Mesut Halici , Zekai Halici Y1 - 2018 PY - 2018 N1 - DO - T2 - Eurasian Journal of Food Science and Technology JF - Journal JO - JOR SP - 53 EP - 68 VL - 2 IS - 2 SN - - M3 - UR - Y2 - 2019 ER -
EndNote %0 Eurasian Journal of Food Science and Technology Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers %A Nurulhünda Hancı , Fehmi Odabasoglu , Fadime Atalay Dumlu , Ozlem Aydın Berktaş , Zerrin Kutlu , Mesut Halici , Zekai Halici %T Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers %D 2018 %J Eurasian Journal of Food Science and Technology %P - %V 2 %N 2 %R %U
ISNAD Hancı, Nurulhünda , Odabasoglu, Fehmi , Atalay Dumlu, Fadime , Aydın Berktaş, Ozlem , Kutlu, Zerrin , Halici, Mesut , Halici, Zekai . "Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers". Eurasian Journal of Food Science and Technology 2 / 2 (December 2018): 53-68.