Abstract
Aim: The aim of this study was to evaluate the characteristics of adult patients followed up for hydatid cysts disease.
Method: Patients over the age of 18 years who were diagnosed with hydatid disease, between January 2015 and September 2021 were included in the study. The clinical, laboratory and radiologic characteristics of the patients were evaluated retrospectively.
Results: The study included 66 patients. 59.1% of the patients were female and the mean age was 40.9±15.60 years. The most common presenting symptom was abdominal pain (42.4%). The most common sites of involvement were the liver (78.8%) and lung (18.2%). The majority of patients had solitary cysts (84.8%). The most common finding in laboratory tests was elevated total IgE (74.1%). The indirect hemagglutination (IHA) test was positive in 77.4% of the patients tested.
Conclusion: In our study, it was concluded that hydatid cysts are most commonly seen in the liver, often with single organ involvement, and that elevated total IgE in laboratory diagnosis may be helpful in the diagnosis of hydatid cyst disease, although it does not make a definitive diagnosis.
References
- Topluoglu S. Current Situation Report of Cystic Echinococcosis in Turkey. Turk Hij Den Biyol Derg 2020; 77(3):1-52.
- Durgun C, Alkan S, Durğun M, Dindar Demiray EK. Analysis of published articles on hydatid cysts from Turkey. BSJ Health Sci 2022; 5(1):45-49.
- WHO. Echinococcosis, Epidemiology 2019. Avaliable from: https://www.who.int/news-room/fact-sheets/detail/echinococcosis [access date: 17 February 2023].
- Başaranoğlu ST, Kara A. Ekinokokkoz; Kist Hidatik. Klinik Tıp Pediatri Dergisi 2019; 11(6):292-297.
- Uysal S, Uyan A, Taşbakan MI, Sipahi OR, Yamazhan T, Pullukçu H, et al. Kist Hidatik Tanılı On Beş Olgunun Klinik Değerlendirmesi. Mediterr J Infect Microb Antimicrob 2015; 4:13.
- Akkaya Işık S, Seyman D, Zerdali E, Ayan S, Kakaliçoğlu D, Ayaz T, et al. Evaluation of 170 Followed-up Cases Treated for Hydatid Disease: A Multicentre Study. Turkiye Parazitol Derg 2020; 44(4):197-202.
- Teggi A, Divico B. The natural history of human cystic echinococcosis by imaging methods. In: Craig P and Pawlowski, editors. Cestode zoonoses: echinococcosis and cysticercosis, an emergent and global problem. Amsterdam: IOS Press; 2002. p. 125-134.
- Yılmaz A, Uslu H, Aktaş F. 2009-2013 Yılları Arasında Erzurum Bölge Hastanesindeki Kistik Ekinokokkozis Şüpheli Hastaların İndirekt Hemaglütinasyon (İHA) Metoduyla Değerlendirilmesi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 2016; 5(1):23-32.
- Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta tropica 2010; 114(1):1-16.
- Gharbi HA, Hassine W, Branner MW. Ultrasound examination of hydatid liver. Radiology 1981; 139:459-463.
- Tamarozzi F, Akhan O, Cretu CM, Vutova K, Akinci D, Chipeva R, et al. Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project. Lancet Infect Dis 2018; 18(7):769-778.
- Güreser AS, Özcan O, Özünel L, Boyacıoğlu Zİ, Taylan Özkan A. Çorum’da kistik ekinokokkoz ön tanısı ile başvuran hastaların radyolojik, biyokimyasal ve serolojik analizlerinin değerlendirilmesi. Mikrobiyol Bul 2015; 49:231-239.
- Türkoğlu E, Demirtürk N, Tünay H, Akıcı M, Öz G, Baskin Embleton D. Evaluation of Patients with Cystic Echinococcosis. Turkiye Parazitol Derg 2017; 41(1):28-33.
- McManus DP, Zhang W, Li J, Bartley PB. Echinococcosis. Lancet 2003; 362(9392): 1295-1304.
- Öztürk-Durmaz Ş, Kesimal U, Turan Mİ. Kist Hidatik Olgularının Değerlendirilmesi: Tek Merkezden İki Yıllık Deneyim. KLIMIK Derg 2020; 33(1):71-6.
- Brundu D, Piseddu T, Stegel G, Masu G, Ledda S, Masala G. Retrospective study of human cystic echinococcosis in Italy based on the analysis of hospital discharge records between 2001 and 2012. Acta Trop 2014; 140:91-96.
- Zeinali M, Mohebali M, Shirzadi MR, Rahimi Esboei B, Erfani H, Pourmozafari J, et al. Human Cystic Echinococcosis in Different Geographical Zones of Iran: An Observational Study during 1995-2014. Iran J Public Health 2017; 46(12):1623-1631.
- Alve O, Payaslıoğlu AM, Özakın C, Esen S. Kistik Ekinokokkozis ile İlgili 2017 ve 2018 Yılları Laboratuvar Sonuçları. Turkiye Parazitol Derg 2021; 45(3):207-210.
- Higuita NIA, Brunetti E, McCloskey C. Cystic echinococcosis. J Clin Microbiol 2016; 54:518-523.
- Smego Jr RA, Sebanego P. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis 2005; 9:69-76.
- Shams-Ul-Bari, Arif SH, Malik AA, Khaja AR, Dass TA, Naikoo ZA. Role of albendazole in the management of hydatid cyst liver. Saudi J Gastroenterol 2011; 17(5):343-347.
- Arif SH, Shams-Ul-Bari, Wani NA, Zargar SA, Wani MA, Tabassum R, et al. Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int J Surg 2008; 6(6):448-451.
- Yeti B, Kilic E. The role of combination pre-and postoperative albendazole therapy in the surgical management of liver hydatidosis. Ann Ital Chir 2018; 89(6):528-533.
- Smego RA Jr, Bhatti S, Khaliq AA, Beg MA. Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis. Clin Infect Dis 2003; 37(8):1073-1083
Abstract
Amaç: Bu çalışmanın amacı kist hidatik nedeniyle takip edilen erişkin hastaların özelliklerini değerlendirmekti.
Yöntem: Çalışmaya Ocak 2015-Eylül 2021 tarihleri arasında kist hidatik tanısı konan 18 yaş üstünde hastalar dahil edildi. Hastalara ait klinik, laboratuvar, radyolojik özellikler retrospektif olarak değerlendirildi.
Bulgular: Çalışmaya 66 hasta dahil edildi. Hastaların %59,1’i kadın cinsiyette olup, yaş ortalaması 40.9±15.60 yıldı. Hastaların en sık tarifledikleri başvuru semptomu karın ağrısıydı (%42,4). En sık tutulum yeri sırasıyla karaciğer (%78,8) ve akciğerdi (%18,2). Hastaların büyük çoğunluğunda soliter kist (%84,8) vardı. Laboratuvar tetkiklerinde en sık saptanan bulgu total IgE yüksekliğiydi (%74,1). İndirekt hemaglütinasyon (IHA) testi, test edilen hastaların % 77,4’ünde pozitif olarak saptandı.
Sonuç: Çalışmamızda kist hidatiğin en sık karaciğerde görüldüğü, sıklıkla tek organ tutulumu şeklinde olduğu, laboratuvar tanısında total IgE yüksekliğinin kist hidatik hastalığınını kesin tanısını koydurmasa da tanıya yardımcı olabileceği sonucuna varıldı.
References
- Topluoglu S. Current Situation Report of Cystic Echinococcosis in Turkey. Turk Hij Den Biyol Derg 2020; 77(3):1-52.
- Durgun C, Alkan S, Durğun M, Dindar Demiray EK. Analysis of published articles on hydatid cysts from Turkey. BSJ Health Sci 2022; 5(1):45-49.
- WHO. Echinococcosis, Epidemiology 2019. Avaliable from: https://www.who.int/news-room/fact-sheets/detail/echinococcosis [access date: 17 February 2023].
- Başaranoğlu ST, Kara A. Ekinokokkoz; Kist Hidatik. Klinik Tıp Pediatri Dergisi 2019; 11(6):292-297.
- Uysal S, Uyan A, Taşbakan MI, Sipahi OR, Yamazhan T, Pullukçu H, et al. Kist Hidatik Tanılı On Beş Olgunun Klinik Değerlendirmesi. Mediterr J Infect Microb Antimicrob 2015; 4:13.
- Akkaya Işık S, Seyman D, Zerdali E, Ayan S, Kakaliçoğlu D, Ayaz T, et al. Evaluation of 170 Followed-up Cases Treated for Hydatid Disease: A Multicentre Study. Turkiye Parazitol Derg 2020; 44(4):197-202.
- Teggi A, Divico B. The natural history of human cystic echinococcosis by imaging methods. In: Craig P and Pawlowski, editors. Cestode zoonoses: echinococcosis and cysticercosis, an emergent and global problem. Amsterdam: IOS Press; 2002. p. 125-134.
- Yılmaz A, Uslu H, Aktaş F. 2009-2013 Yılları Arasında Erzurum Bölge Hastanesindeki Kistik Ekinokokkozis Şüpheli Hastaların İndirekt Hemaglütinasyon (İHA) Metoduyla Değerlendirilmesi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 2016; 5(1):23-32.
- Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta tropica 2010; 114(1):1-16.
- Gharbi HA, Hassine W, Branner MW. Ultrasound examination of hydatid liver. Radiology 1981; 139:459-463.
- Tamarozzi F, Akhan O, Cretu CM, Vutova K, Akinci D, Chipeva R, et al. Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project. Lancet Infect Dis 2018; 18(7):769-778.
- Güreser AS, Özcan O, Özünel L, Boyacıoğlu Zİ, Taylan Özkan A. Çorum’da kistik ekinokokkoz ön tanısı ile başvuran hastaların radyolojik, biyokimyasal ve serolojik analizlerinin değerlendirilmesi. Mikrobiyol Bul 2015; 49:231-239.
- Türkoğlu E, Demirtürk N, Tünay H, Akıcı M, Öz G, Baskin Embleton D. Evaluation of Patients with Cystic Echinococcosis. Turkiye Parazitol Derg 2017; 41(1):28-33.
- McManus DP, Zhang W, Li J, Bartley PB. Echinococcosis. Lancet 2003; 362(9392): 1295-1304.
- Öztürk-Durmaz Ş, Kesimal U, Turan Mİ. Kist Hidatik Olgularının Değerlendirilmesi: Tek Merkezden İki Yıllık Deneyim. KLIMIK Derg 2020; 33(1):71-6.
- Brundu D, Piseddu T, Stegel G, Masu G, Ledda S, Masala G. Retrospective study of human cystic echinococcosis in Italy based on the analysis of hospital discharge records between 2001 and 2012. Acta Trop 2014; 140:91-96.
- Zeinali M, Mohebali M, Shirzadi MR, Rahimi Esboei B, Erfani H, Pourmozafari J, et al. Human Cystic Echinococcosis in Different Geographical Zones of Iran: An Observational Study during 1995-2014. Iran J Public Health 2017; 46(12):1623-1631.
- Alve O, Payaslıoğlu AM, Özakın C, Esen S. Kistik Ekinokokkozis ile İlgili 2017 ve 2018 Yılları Laboratuvar Sonuçları. Turkiye Parazitol Derg 2021; 45(3):207-210.
- Higuita NIA, Brunetti E, McCloskey C. Cystic echinococcosis. J Clin Microbiol 2016; 54:518-523.
- Smego Jr RA, Sebanego P. Treatment options for hepatic cystic echinococcosis. Int J Infect Dis 2005; 9:69-76.
- Shams-Ul-Bari, Arif SH, Malik AA, Khaja AR, Dass TA, Naikoo ZA. Role of albendazole in the management of hydatid cyst liver. Saudi J Gastroenterol 2011; 17(5):343-347.
- Arif SH, Shams-Ul-Bari, Wani NA, Zargar SA, Wani MA, Tabassum R, et al. Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int J Surg 2008; 6(6):448-451.
- Yeti B, Kilic E. The role of combination pre-and postoperative albendazole therapy in the surgical management of liver hydatidosis. Ann Ital Chir 2018; 89(6):528-533.
- Smego RA Jr, Bhatti S, Khaliq AA, Beg MA. Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis. Clin Infect Dis 2003; 37(8):1073-1083
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Original Article |
| Authors | |
| Early Pub Date | April 27, 2024 |
| Publication Date | April 30, 2024 |
| Submission Date | March 27, 2023 |
| Published in Issue | Year 2024 Volume: 34 Issue: 2 |
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