Analytical Tools for Instant Determination of New Psychoactive Substances in Biological Samples and Drug Seizures
Öz
Identification and quantification of new drugs and metabolites
without possessing the required reference standards is a challenge. Although
reference standards may be available from commercial, governmental
and international sources, their delivery time is lengthy, ranging from several
weeks to several months. In this paper, some analytical tools are described
that are probably helpful in the combat against NPS on an international
level.
Anahtar Kelimeler
New Psychoactive Substances Synthetic Opioids Synthetic Stimulants High-Resolution Mass Spectrometry Chemiluminescence Nitrogen Detection
Kaynakça
- Kriikku, P., Pelander, A., Rasanen, I. ve Ojanperä, I. (2019). Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data. Forensic Sci Int, C. 300, ss. 85-88.
- Mesihää, S., Rasanen, I., Pelander, A. ve Ojanperä, I. (2019). Quantitative estimation of 38 illicit psychostimulants in blood by GC-APCI-QTOFMS with nitrogen chemiluminescence etection based on three external calibrators. J Anal Toxicol, C. 44, S. 2, ss. 163-172.
- Rasanen, I., Kyber, M., Szilvay, I., Rintatalo, J. ve Ojanperä, I. (2019) Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection. Forensic Sci Int, C. 305.
- Sundström, M., Pelander, A. ve Ojanperä, I. (2017). Comparison of post-targeted and pretargeted urine drug screening by UHPLC-HR-QTOFMS. J Anal Toxicol, C. 41, S. 7, ss. 623-630.
- United Nations. (2019). World Drug Report. https://wdr.unodc.org/wdr2019/prelaunch/ WDR19_Booklet_1_EXECUTIVE_SUMMARY.pdf E.T. 9 Kasım 2019.
Biyojenik Örneklerde ve Uyuşturucu Ele Geçirmelerde Yeni Psikoaktif Maddelerin Anında Tespiti İçin Analitik Araçlar
Öz
Gerekli referans standartlara sahip olmadan yeni ilaçların ve metabolitlerin tanımlanması ve miktarının belirlenmesi bir zorluktur. Referans standartları ticari, hükümet ve uluslararası kaynaklardan temin edilebilir olsa da, teslim süreleri birkaç haftadan birkaç aya kadar uzun olabilir. Bu makalede, uluslararası düzeyde NPS ile mücadelede muhtemelen yardımcı olabilecek bazı analitik araçlar tanımlanmıştır.
Anahtar Kelimeler
Yeni Psikoaktif Maddeler Sentetik Oioidler Sentetik Uyarıcılar Yüksek Çözünürlüklü Kütle Sptekrometrisi Kemilüminesans Azot Tespiti
Kaynakça
- Kriikku, P., Pelander, A., Rasanen, I. ve Ojanperä, I. (2019). Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data. Forensic Sci Int, C. 300, ss. 85-88.
- Mesihää, S., Rasanen, I., Pelander, A. ve Ojanperä, I. (2019). Quantitative estimation of 38 illicit psychostimulants in blood by GC-APCI-QTOFMS with nitrogen chemiluminescence etection based on three external calibrators. J Anal Toxicol, C. 44, S. 2, ss. 163-172.
- Rasanen, I., Kyber, M., Szilvay, I., Rintatalo, J. ve Ojanperä, I. (2019) Single-calibrant quantification of seized synthetic opioids by liquid chromatography-chemiluminescence nitrogen detection. Forensic Sci Int, C. 305.
- Sundström, M., Pelander, A. ve Ojanperä, I. (2017). Comparison of post-targeted and pretargeted urine drug screening by UHPLC-HR-QTOFMS. J Anal Toxicol, C. 41, S. 7, ss. 623-630.
- United Nations. (2019). World Drug Report. https://wdr.unodc.org/wdr2019/prelaunch/ WDR19_Booklet_1_EXECUTIVE_SUMMARY.pdf E.T. 9 Kasım 2019.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Adli Biyoloji |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 11 Eylül 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 2 Sayı: 1 |
