Hepatosellüler karsinomada p53 gen tedavisi

Abstract

Hepatoselüler karsinom malign bir tümör olup morbidite ve mortalitesi yüksektir. Sık infiltrasyon nedeniyle kötü prognoz gösterir. Karaciğer kanseri, viral ve çevresel faktörlerle kombinasyon halinde genetik değişikliklerden kaynaklanmaktadır. p53 mutasyonları, hepatoselüler karsinomada tanımlanan ana genetik değişikliği temsil eder. Bu nedenle, potansiyel bir tedavi olarak p53 gen tedavisi önerilmektedir. P53 tümör süpresör geni, tümör sinyallerindeki apoptotik sinyallerden ve dolayısıyla kontrol edilemeyen çoğalması ve nüksden sorumludur. Hastanın tedavisinde hepatoselüler karsinom tedavisine yeni yaklaşımlar gereklidir.

Keywords

• gen tedavisi,hepatosellüler karsinoma,karaciğer

P53 gene therapy for hepatocellular carcinoma

Abstract

Hepatocellular carcinoma is a malignant tumor with a very high morbidity and mortality. It has a poor prognosis due to its common infiltrating. Liver carcinogenesis is driven by genetic alterations in combination with viral and environmental factors. P53 mutations represent main genetic alteration described in hepatocellular carcinoma. Because of this, p53 gene therapy is proposed as a potential treatment. P53 tumour suppressor gene is responsible for apoptotic signals in tumour signals and thus for their uncontrolled proliferation and recurrence. New approaches to hepatocellular carcinoma treatment are needed to improve patient survival. 

Keywords

• gene therapy,hepatocellular carcinoma,liver cancer

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