Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Year 2018, , 127 - 131, 30.11.2018

Aslı Çalışkan Uçkun , Fatma Gül Yurdakul , Ayşegül Kılıçarslan Bedriye Başkan Filiz Sivas , Semra Duran , Hatice Bodur

https://doi.org/10.25000/acem.440559

Cited By: 1

Abstract

Amaç: Bu çalışmadaki amaçlarımız, romatoid
artrit (RA) hastalarında D vitamini düzeylerini ve D vitamini düzeylerinin
objektif ve subjektif değerlendirmelere etkisini belirlemektir.

Yöntemler: Bu çalışma, 108 RA hastası ve yaş
ve cinsiyete göre eşleştirilmiş 50 sağlıklı kontrol üzerinde yapılan bir prospektif
olgu-kontrol çalışmasıdır. Öncelikle RA hastaları ve kontroller arasında D
vitamini düzeylerini karşılaştırdık. RA hastalarının demografik ve klinik
verileri, hastalık aktivitesi parametreleri, inflamatuvar belirteçleri, romatoid
faktör ve anti-siklik sitrüllenmiş peptid seropozitifliği ve radyolojik hasar
skorları kaydedildi. Hastalardan ayrıca RA Yaşam Kalitesi Anketi (Rheumatoid
Arthritis Quality of Life, RAQoL), yorgunluk şiddet ölçeği (Fatigue Severity
Scale, FSS) ve Sağlık Değerlendirme Anketi (Health Assessment Questionnaire, HAQ)
tamamlamaları istendi.

Bulgular: RA hastalarında D vitamin düzeyleri
sağlıklı kontrollerden anlamlı derecede düşüktü (p=0,001). RA hastalarının %
73'ünde ve kontrollerin % 52'sinde D vitamini eksikliği tespit edildi. D
vitamini eksikliği, hastalık aktivitesi ile ilişkili değildi (p=0,862). D
vitamini seviyeleri ile tüm subjektif ve objektif değerlendirmeler arasında
anlamlı bir ilişki bulunamadı (hepsi için p>0,050).

Sonuç:  D
vitamini eksikliği RA hastalarında normal popülasyona göre daha sık
görülmektedir.  Ancak, vitamin D
düzeyleri ile hastalık aktivitesi, inflamatuvar belirteçler, romatoid faktör ve
anti-siklik sitrüllenmiş peptid seropozitifliği, radyolojik hasar skorları ve RAQoL,
FSS, HAQ ile ilişkili hastalığın objektif ve subjektif değerlendirmeleri
arasında anlamlı bir ilişki bulunduğu gösterilemedi.

Keywords

Romatoid Artrit, D vitamini, radyolojik hasar

Impact of vitamin D on rheumatoid arthritis: real or just patient’s perception?

Abstract

Aim: In this study, our aims were to identify
vitamin D levels in rheumatoid arthritis (RA) individuals as compared to
controls and the impact of vitamin D levels on both objective and subjective
assessments in RA patients.

Methods: The current study was a prospective
case-control study conducted
on 108 RA patients and 50 age-gender matched healthy controls. We first
compared the levels of vitamin D among the RA patients and controls.
Demographic and clinical data, parameters of disease activity, inflammatory
markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity
and radiological damage scores were recorded in RA patients. These patients
were also demanded to complete RA Quality of Life Questionnaire (RAQoL),
fatigue severity scale (FSS)  and Health
Assessment Questionnaire (HAQ).

Results: D vitamin levels in RA patients were
significantly lower than healthy controls (p=0.001). Vitamin D deficiency was
determined in 73% of the RA patients and 52% of the controls. Vitamin D
deficiency was not associated with disease activity (p=0.862). There was no
significant relationship among vitamin D levels and all subjective and
objective assessments (p>0.05 for all ).

Conclusion: Vitamin D deficiency was common in
RA participants than normal population. However, it was not shown that there
was a significant relationship between vitamin D levels and objective and
subjective assessments of disease, including disease activity, inflammatory markers,
rheumatoid factor and anti-cyclic citrullinated peptide seropositivity,
radiological damage scores, RAQoL, FSS and HAQ.

Keywords

Rheumatoid Arthritis, Vitamin D, radiological damage

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