Evaluation of relationship between disease severity, mean platelet volume, and platelet distribution width in stable chronic obstructive pulmonary disease

Year 2018, , 132 - 137, 30.11.2018

Pelin Uysal

https://doi.org/10.25000/acem.444456

Cited By: 1

Abstract

Aim: This study was conducted to evaluate the relationship between
disease severity, mean platelet volume and platelet distribution width in
stable chronic obstructive pulmonary disease.

Methods: The study included 120 consecutive patients with stable chronic
obstructive pulmonary disease and 30 consecutive
age-matched healthy subjects (control
group). Patients
were classified as A (mild), B (mild to moderate), C (moderate to severe) and D
(severe) defined by the GOLD committee and grouped as A/B (n= 60) and C/D
(n=60).

Results: Platelet levels were not different among the groups. Mean
platelet volume was lower in all patients than control group (p=0.001). Level
of platelet distribution width was higher in all patients than control group (p=0.018).
Mean platelet volume in C/D groups were significantly lower than A/B group (p=0.011)
and control group (p=0.001). Mean platelet volume in A/B group were also significantly
lower than control group (p=0.001). Erythrocyte sedimentation rates were higher
in A/B and C/D groups than control group (p=0.007 and p=0.001, respectively). C-reactive
protein levels in control group were significantly lower than C/D group (p=0.001).
No statistically significant correlations were observed between mean platelet volume and forced
expiratory volume in one second and forced expiratory volume in one second/forced
vital capacity or between mean platelet volume and other inflammatory
parameters in A/B or C/D groups. Significant positive
correlations were found between erythrocyte sedimentation rate and C-reactive
protein (r=0.375; p=0.003), and between mean platelet volume and platelet
large cell ratio (r=0.749; p=0.001) in
C and D groups.

Conclusion: It was concluded that mean platelet volume could be used as a negative acute‑phase
reactant in evaluation of disease
severity of chronic obstructive pulmonary disease as C-reactive protein. 

Keywords

Chronic obstructive pulmonary disease, mean platelet volume, platelet distribution width, forced expiratory volume, forced vital capacity

Stabil kronik obstrüktif akciğer hastalığında ortalama trombosit hacmi ve trombosit dağılım genişliğinin hastalık şiddeti ile ilişkisinin değerlendirilmesi

Abstract

Amaç: Bu çalışmada kronik obstrüktif akciğer hastalığında ortalama
trombosit hacmi ve trombosit dağılım genişliği ile hastalık şiddeti arasındaki
ilişkinin değerlendirilmesi amaçlandı.

Yöntemler: Çalışmaya 120 ardışık kronik obstrüktif akciğer hastası ve
yaşları eşleştirilmiş 30 ardışık sağlıklı kişi (kontrol grubu) alındı. GOLD komitesi
tarafından tanımlanan kronik obstrüktif
akciğer hastalığı şiddetini belirlemek için hastalar A (hafif), B (hafif-orta),
C (orta-şiddetli) ve D (şiddetli) olarak sınıflandı ve A/B (n=60) ve C/D (n=60)
olarak gruplandı.

Bulgular: Gruplar arasında trombosit düzeylerinin istatistiksel olarak
anlamlı olmadığı bulundu. Ortalama trombosit hacmi tüm hastalarda kontrollere
göre daha düşüktü (p=0.001). Tüm hastalarda trombosit
dağılım genişliği düzeyleri kontrol grubundan daha yüksekti (p=0.018). Ortalama trombosit
hacmi C/D grubunda, A/B grubu (p=0.011) ve kontrol grubundan (p=0.001) anlamlı olarak düşük
bulundu. Ortalama trombosit hacmi, A/B
grubunda kontrol grubundan anlamlı derecede düşük bulundu (p=0.001). Eritrosit sedimantasyon
hızı A/B ve C/D gruplarında kontrol
grubundan daha yüksek iken (sırasıyla, p=0.007 ve p=0.001). C-reaktif protein düzeyleri kontrol grubunda C/D grubundan anlamlı
derecede düşük bulundu (p=0.001). A/B veya C/D
gruplarında ortalama trombosit hacmi ile bir saniyedeki zorlu ekspiratuar
hacim, bir saniyedeki zorlu ekspiratuar hacim/zorlu vital kapasite oranı ve
diğer inflamatuar parametreler arasında istatistiksel olarak anlamlı bir ilişki
görülmedi. C/D grubunda eritrosit
sedimantasyon hızı, C-reaktif protein düzeyleri (r=0.375; p=0.003) ile ve ortalama
trombosit hacmi de büyük hücreli platelet oranı ile (r=0.749; p=0.001) pozitif korelasyon gösterdi.

Sonuç: Bu çalışma kronik obstrüktif akciğer hastalığında klasik pozitif
akut faz reaktanı C-reaktif proteinin yanı sıra düşük ortalama trombosit hacmi’nin
hastalık şiddetinin değerlendirilmesinde negatif akut faz reaktanı olarak
kullanılabileceğini düşündürmektedir. 

Keywords

Kronik obstrüktif akciğer hastalığı, ortalama trombosit volümü, trombosit dağılım genişliği, zorlu ekspiratuar hacim, zorlu vital kapasite

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