Anjiyografik SYNTAX skoru ile değerlendirilen koroner arter hastalığı ciddiyetinde kalsiyum-albumin oranının rolü

Year 2018, , 174 - 178, 30.11.2018

Yakup Alsancak , Serkan Sivri , Serdal Baştuğ , Engin Bozkurt

https://doi.org/10.25000/acem.450950

Cited By: 2

Abstract

Amaç: Serum kalsiyum ve albumin seviyeleri
ile akut koroner sendromlar ve koroner arter hastalığı arasındaki ilişki birçok
çalışmada gösterilmiştir. Sunulan çalışmada, serum albumin, kalsiyum,
albumin-düzeltilmiş kalsiyum seviyeleri ve kalsiyum/albumin oranı (KAO) ile
aterosklerozun yaygınlık ve ciddiyetinin ilişkisi araştırılmıştır.

Yöntemler: Bu prospektif çalışmaya non-ST
elevasyonlu miyokard infarktüsü olan hastalar (NSTEMI, n=120) ve kontrol grubu
(n=109) dahil edildi. KAO ile koroner arter hastalığı yaygınlık ve ciddiyetinin
ilişkisini değerlendirmek için SYNTAX skoru kullanıldı.

Bulgular: NSTEMI hastalarında istatistiksel
anlamlı olmadan daha yüksek kalsiyum seviyeleri vardı (p=0.058). Buna rağmen
serum albumin-düzeltilmiş kalsiyum seviyeleri istatistiksel anlamlı olarak
NSTEMI grubunda daha yüksekti (p=0.001). Albumin seviyeleri ise gruplar
arasında farklılık göstermedi (p=0.093). KAO ve düzeltilmiş kalsiyum/albumin
oranı (dKAO), NSTEMI grubunda anlamlı olarak daha yüksekti (p=0.001). KAO (r=0.235,
p=0.010) ve dKAO (r=0.259, p=0.004) ile SYNTAX skoru arasında pozitif korelasyon
mevcut iken, albumin ile SYNTAX skoru (r=−0.259, p=0.004) arasında negatif
korelasyon görüldü.

Sonuç: Kalsiyum/albumin oranı, SYNTAX skoru ile
hesaplanan artmış koroner aterosklerotik yük ile ilişkili bulunmuştur.
Bulgularımızı doğrulamak için daha geniş çaplı çalışmalar gereklidir.

Keywords

Non-ST elevasyonlu akut miyokard infarktüsü, SYNTAX skoru, kalsiyum-albumin oranı

Role of calcium–albumin ratio in severity of coronary artery disease assessed by angiographic SYNTAX score

Abstract

Aim: Numerous studies have reported a
relationship between serum calcium or albumin levels and acute coronary
syndromes and coronary artery disease. The present study investigated the
relation between serum albumin, calcium or albumin-corrected calcium levels or
calcium/albumin ratio (CAR) and extensiveness and severity of atherosclerosis.

Methods: This prospective study included
patients with non-ST elevation myocardial infarction (NSTEMI, n=120) and a
control group (n=109). We used the SYNTAX score to evaluate the association
between CAR and severity and extent of coronary artery disease.

Results: There were higher, but statistically
nonsignificant, levels of calcium in patients with NSTEMI (p=0.058). However,
serum albumin-corrected calcium levels were significantly higher in NSTEMI
group (p=0.001). Yet, albumin levels did not differ between the groups
(p=0.093). CAR and corrected calcium–albumin ratio (cCAR) were significantly
higher in NSTEMI group (p=0.001). A positive correlation existed between CAR (r=0.235,
p=0.010), cCAR (r=0.259, p=0.004), and SYNTAX score, whereas albumin and SYNTAX
score (r=−0.259, p=0.004) showed a negative correlation.

Conclusion: Calcium/albumin ratio has been
found to be associated with an increased coronary atherosclerotic burden as
calculated by SYNTAX score. Further large-scale studies are warranted to
confirm our findings.

Keywords

Non-ST elevation acute myocardial infarction, SYNTAX score, calcium-albumin ratio

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