Anjiyografik SYNTAX skoru ile değerlendirilen koroner arter hastalığı ciddiyetinde kalsiyum-albumin oranının rolü

Öz

Amaç: Serum kalsiyum ve albumin seviyeleri ile akut koroner sendromlar ve koroner arter hastalığı arasındaki ilişki birçok çalışmada gösterilmiştir. Sunulan çalışmada, serum albumin, kalsiyum, albumin-düzeltilmiş kalsiyum seviyeleri ve kalsiyum/albumin oranı (KAO) ile aterosklerozun yaygınlık ve ciddiyetinin ilişkisi araştırılmıştır.

Yöntemler: Bu prospektif çalışmaya non-ST elevasyonlu miyokard infarktüsü olan hastalar (NSTEMI, n=120) ve kontrol grubu (n=109) dahil edildi. KAO ile koroner arter hastalığı yaygınlık ve ciddiyetinin ilişkisini değerlendirmek için SYNTAX skoru kullanıldı.

Bulgular: NSTEMI hastalarında istatistiksel anlamlı olmadan daha yüksek kalsiyum seviyeleri vardı (p=0.058). Buna rağmen serum albumin-düzeltilmiş kalsiyum seviyeleri istatistiksel anlamlı olarak NSTEMI grubunda daha yüksekti (p=0.001). Albumin seviyeleri ise gruplar arasında farklılık göstermedi (p=0.093). KAO ve düzeltilmiş kalsiyum/albumin oranı (dKAO), NSTEMI grubunda anlamlı olarak daha yüksekti (p=0.001). KAO (r=0.235, p=0.010) ve dKAO (r=0.259, p=0.004) ile SYNTAX skoru arasında pozitif korelasyon mevcut iken, albumin ile SYNTAX skoru (r=−0.259, p=0.004) arasında negatif korelasyon görüldü.

Sonuç: Kalsiyum/albumin oranı, SYNTAX skoru ile hesaplanan artmış koroner aterosklerotik yük ile ilişkili bulunmuştur. Bulgularımızı doğrulamak için daha geniş çaplı çalışmalar gereklidir.

Anahtar Kelimeler

• Non-ST elevasyonlu akut miyokard infarktüsü,SYNTAX skoru,kalsiyum-albumin oranı

Role of calcium–albumin ratio in severity of coronary artery disease assessed by angiographic SYNTAX score

Abstract

Aim: Numerous studies have reported a relationship between serum calcium or albumin levels and acute coronary syndromes and coronary artery disease. The present study investigated the relation between serum albumin, calcium or albumin-corrected calcium levels or calcium/albumin ratio (CAR) and extensiveness and severity of atherosclerosis.

Methods: This prospective study included patients with non-ST elevation myocardial infarction (NSTEMI, n=120) and a control group (n=109). We used the SYNTAX score to evaluate the association between CAR and severity and extent of coronary artery disease.

Results: There were higher, but statistically nonsignificant, levels of calcium in patients with NSTEMI (p=0.058). However, serum albumin-corrected calcium levels were significantly higher in NSTEMI group (p=0.001). Yet, albumin levels did not differ between the groups (p=0.093). CAR and corrected calcium–albumin ratio (cCAR) were significantly higher in NSTEMI group (p=0.001). A positive correlation existed between CAR (r=0.235, p=0.010), cCAR (r=0.259, p=0.004), and SYNTAX score, whereas albumin and SYNTAX score (r=−0.259, p=0.004) showed a negative correlation.

Conclusion: Calcium/albumin ratio has been found to be associated with an increased coronary atherosclerotic burden as calculated by SYNTAX score. Further large-scale studies are warranted to confirm our findings.

Keywords

• Non-ST elevation acute myocardial infarction,SYNTAX score,calcium-albumin ratio

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