Migren hastalarında enflamatuvar belirteçlerin değerlendirilmesi

Year 2019, , 37 - 40, 15.03.2019

Aysel Tekeşin , Abdülkadir Tunç

https://doi.org/10.25000/acem.494415

Cited By: 7

Abstract

Amaç: Bu
çalışmanın amacı migren hastalarında eritrosit sedimentasyon hızı (ESR), yüksek
duyarlılıklı C-reaktif protein (hsCRP), nötrofil-lenfosit oranı (NLO),
monosit-HDL-C oranı (MHO) ve bilirubin düzeylerinin değerlendirilmesi ve
sağlıklı bireylerde ölçülen seviyelerle karşılaştırılmasıdır.

Yöntemler:
Bu retrospektif vaka-kontrol çalışmasına Haziran 2017-Haziran 2018 tarihleri
arasında hastanemiz nöroloji polikliniğine veya acil servisine başvuran 136
migren hastası ve 80 sağlıklı kontrol dahil edildi. Tüm katılımcıların
laboratuvar tetkikleri, hastalık özellikleri, aura varlığı ve beyaz cevher
lezyonlarının varlığı kaydedildi ve demografik özellikler ve laboratuvar
verileri iki grup arasında karşılaştırıldı.

Bulgular:
Vaka grubunun yaş ortalaması 36.9 ±10.6 yıl ve kontrol grubunun 37±12 yıl idi.
Hasta ve kontrol grupları arasında yaş ve cinsiyet açısından anlamlı fark
saptanmadı. Vaka grubunda total bilirubin, direkt bilirubin, indirekt
bilirubin, lenfosit değerleri kontrol grubuna göre anlamlı derecede düşüktü.
Hasta grubunda NLO, hsCRP, ESR düzeyleri kontrol grubuna göre anlamlı yüksekti.
Vaka ve kontrol grupları beyaz cevher lezyonları varlığı açısından anlamlı
farklılık göstermedi. Aurası olan ve olmayan migren hastalarında yaş, cinsiyet,
total bilirubin, direkt bilirubin ve indirekt bilirubin değerleri, NLO, ürik
asit, lenfosit ve ESR düzeyleri açısından anlamlı fark saptanmadı. Auralı
grupta monosit ve MHO değerleri aurasız gruba göre yüksekti. Auralı grupta
hsCRP değeri aurasız gruba göre istatistiksel olarak anlamlı düşüktü.

Sonuç: Bu
çalışma, migren hastalarında düşük bilirubin ve yüksek NLO, CRP ve ESR
değerlerinin potansiyel enflamatuvar marker olabileceğini göstermiştir. Bu
markerlar hastalığın patofizyolojisini anlamamıza katkıda bulunabilir. Ayrıca
söz konusu testlerin maliyeti ucuz ve yaygın kullanılan tetkikler olduğundan
özellikle migren hastalarını olası uzun dönem komorbiditelerden korumak
açısından faydalı olabileceği görüşündeyiz. 

Keywords

Migren, enflamasyon, laboratuvar, biyomarker

Evaluation of inflammatory markers in patients with migraine

Abstract

Aim: The aim of this
study was to evaluate erythrocyte sedimentation rate (ESR), high sensitivity
C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), monocyte to
HDL-C ratio (MHR), and bilirubin levels in patients with migraine and compare
with levels measured in healthy subjects.

Methods: This
retrospective case-control study included 136 migraine patients and 80 healthy
controls who were admitted to our neurology outpatient clinic or emergency
between June 2017 and June 2018. Laboratory examinations, disease
characteristics, presence of aura, and the presence of white matter
hyperintensities (WMHs) were recorded and demographic features and laboratory
data were compared between two groups.

Results: The mean age
of the case group was 36.9 ± 10.6 years and the control group was 37 ± 12
years. In the patient group, total bilirubin, direct bilirubin, indirect
bilirubin, and lymphocyte values were significantly lower than the control
group. NLR, hsCRP, and ESR levels were significantly higher in the patient
group than the control group. The patient and control groups did not show a
significant difference according to the presence of WMHs. In the group with
aura, monocyte and MHR values were higher than those without aura. The hsCRP
values in the group with aura were significantly lower than the group without
aura.

Conclusion: This study
showed that low bilirubin and high NLR, MHR, hsCRP, and ESR values might be
potential inflammatory markers in migraine patients. These markers may
contribute to our understanding of the pathophysiology of migraine. Since the
cost of these tests is cheap and they are widely used, it is possible to
believe that they may be useful for protecting migraine patients against
long-term comorbidities.

Keywords

Migraine, inflammation, laboratories, biomarker

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