The Short-term Results of Cytoreduction+Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Grade IIIC and IV Ovarian Cancer

Abstract

Aim: Cytoreductive surgery (CRS) applied together with hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to prolong survival in advanced stage ovarian cancer. The aim of this study was to present the short-term results of patients with primary and recurrent advanced stage ovarian cancer applied with CRS+HIPEC in a single centre. Methods: A retrospective examination was made of 18 patients with a diagnosis of advanced stage ovarian cancer applied with CRS+HIPEC in a single centre between May 2019 and March 2020. A record was made for each patient of demographic data, CA125 values, peritoneal carcinomatosis index (PCI), completeness of cytoreduction score (CC), surgical procedures applied to the patient, complications, disease-free survival (DFS) and overall survivial (OS). Results: In the group with PCI ≥10, DFS was 18 months, and OS was 19 months, and the group with PCI ≤9, DFS and OS were found to be 20 months. No significant difference was determined between the two groups in respect of DFS and OS (p>0.05). In patients with CC0, DFS and OS were calculated as 20 months, and in those with CC1+CC2, DFS was 12 months and OS was 13.2 months. A statistically significant difference was determined between the two groups in respect of DFS and OS (p>0.05). Conclusion: The study results demonstrated that optimal CRS applied together with HIPEC to patients with advanced stage ovarian cancer prolonged survival. The operations of these patients should be performed by experienced surgical oncology and gynaecology oncology surgery specialists.

Keywords

• Cytoreduction
• HIPEC
• hyperthermia
• ovarian cancer
• survival

Evre IIIC ve IV Over Kanserli Hastalarda Kısa Dönem Sitoredüksiyon + Hipertermik İntraperitoneal Kemoterapi (HIPEC) Sonuçlarımız

Öz

Amaç: İleri evre over kanserinde sitoredüktif cerrahi (CRS) ile birlikte yapılan Hipertermik İntraperitoneal Kemoterapi (HIPEC)’nin sağkalımı artırdığı gösterilmiştir. Bu çalışmada; tek merkezde primer ve rekürren ileri evre over kanseri tanısı ile CRS+HIPEC yapılan hastaların erken dönem sonuçlarını sunmayı amaçladık. Yöntemler: Mayıs-2019 ile mart-2020 tarihleri arasında tek merkezde ileri evre over kanseri tanısı ile CRS +HIPEC yapılan hastaların sonuçları retrospektif olarak incelendi. Hastaların; demografik verileri, preopereatif CA125 değerleri, petitoneal karsinomatozis indexi (PCI), comleteness of cytoreduction skoru (CC), hastalara yapılan cerrahi işlemler ve komplikasyonları, postoperatif takip süreleri, hastalıksız sağkalım (DFS) ve genel sağkalım (OS) süreleri kayıt altına alındı. Bulgular: PCI≥10 olan grupta DFS 18 ay, OS 19 ay iken, PCI≤9 olan grupta DFS ve OS 20 ay olarak bulunmuştur. İki grup arasında DFS ve OS’de anlamlı fark yoktur (p>0,05). CC0 olanlarda DFS ve OS 20 ay, CC1+CC2’de ise DFS 12 ay, OS 13,2 ay olarak hesaplanmıştır. İki grup arasında DFS ve OS’de istatistiksel anlamlı fark mevcuttur (p<0,05). Sonuç: İleri evre over kanserlerinde optimal CRS ile birlikte yapılan HIPEC’in sağkalımı uzattığını düşünüyoruz. Bu hastaların operasyonlarının deneyimli cerrahi onkoloji ve jinekolojik onkoloji cerrahisi uzmanları tarafından yapılması gerektiği görüşündeyiz.

Anahtar Kelimeler

• Sitoredüksiyon
• HIPEK
• hipertermi
• over kanseri
• sağkalım

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