Year 2017, Volume 2 , Issue 3, Pages 66 - 70 2017-12-01

Plasma Urotensin II Concentration In Gestational Diabetes
Gestasyonel Diyabette Plazma Ürotensin II Konsantrasyonu

Mehmet HURSİTOGLU [1] , Ali EKİZ [2] , Fatih METE [3] , Yıldız OKUTURLAR [4] , Hakan KOCOGLU [5] , Guleren DUMANLİ [6] , Mustafa CAKİRCA [7] , Gulden ANATACA [8] , Oguzhan KURU [9] , Serkan DOGAN [10] , Bahar PEHLİVAN [11] , Omur TABAK [12] , Gokhan Yildirim [13] , Hakan Dogan [14] , Betul Erismis [15]


Aim: Urotensin II (UII) and its system is implicated in the etiology of many diseases (including diabetes mellitus). We tried in this study to evaluate and compare UII levels in gestational diabetes mellitus (GDM).

Methods: Thirty-six pregnant women (15 non-GDM patients consisted group 1 and 21 GDM patients consisted group 2) enrolled in this study. The 3rd group consisted of age matched 22 non pregnant healthy women. Plasma UII levels were determined at the beginning of the study. After 12 weeks of delivery, a second plasma UII was determined from group 1 and 2.

Results: Gestational UII levels of both GDM and non-GDM patients were higher than non-pregnant healthy controls (p=0.0001 for both). Both gestational and postpartum UII levels of GDM patients were higher than non-GDM patients but had not reached statistical significance (P≥0.05). Plasma UII concentrations in non-GDM patients significantly decreased after delivery but not in GDM patients (p=0.036 and p≥0.05, respectively).

Conclusion: The finding of elevated gestational plasma UII concentrations in GDM patients which did not decrease significantly after delivery (in compare to non-GDM patients) shows that plasma UII levels may have a role in the pathogenesis of GDM. Further detailed studies are needed in this field.

Amaç: Urotensin II (UII) ve sistemi, birçok hastalığın (diyabet dahil) etyolojisinde rol oynar. Bu çalışmada gestasyonel diabetes mellitusta (GDM) UII'yi değerlendirmek ve karşılaştırmayı denedik.

Yöntemler: Çalışmaya alınan otuzaltı gebe (GDM olmayan 15 kadın hasta 1. Grubu ve 21 GDM kadın hasta 2. Grubu  oluşturdu). Üçüncü grup, yaşları eşleştirilmiş 22 gebe olmayan sağlıklı bireyden oluşuyordu. Plazma UII seviyeleri çalışmanın başında belirlendi. Doğum sonrası 12.hafta ikinci bir plazma UII düzeyi grup 1 ve 2 'deki hastalardan ölçüldü.

Bulgular: Hem GDM hem de GDM olmayan deneklerin Gestasyonel UII düzeyleri, gebe olmayan sağlıklı kontrollere göre daha yüksekti (her ikisi için p=0,0001). GDM'li hastaların gestasyonel ve postpartum UII düzeyleri, GDM'li olmayan gebelere göre daha yüksekti ancak istatistiksel olarak anlamlı değildi (p≥0.05). GDM'li olmayan kişilerde plazma UII konsantrasyonları, doğumdan sonra anlamlı olarak azaldı, ancak GDM'li kişilerde değişmedi (sırasıyla, p=0,036 ve p ≥0.05).

Sonuç: GDM hastalarında doğumdan sonra anlamlı bir şekilde azalmayan plazma UII konsantrasyonlarının yüksek bulunması (GDM olmayan bireylerle karşılaştırıldığında), UII'nin ve sisteminin GDM patogenezinde rol oynayabileceğini göstermektedir. Bu alanda daha ayrıntılı çalışmalara ihtiyaç vardır.

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Subjects General and Internal Medicine
Journal Section Original Research
Authors

Author: Mehmet HURSİTOGLU
Country: Turkey


Author: Ali EKİZ

Author: Fatih METE

Author: Yıldız OKUTURLAR

Author: Hakan KOCOGLU

Author: Guleren DUMANLİ

Author: Mustafa CAKİRCA

Author: Gulden ANATACA

Author: Oguzhan KURU

Author: Serkan DOGAN

Author: Bahar PEHLİVAN

Author: Omur TABAK

Author: Gokhan Yildirim

Author: Hakan Dogan

Author: Betul Erismis

Dates

Publication Date : December 1, 2017

Bibtex @research article { acem336837, journal = {Archives of Clinical and Experimental Medicine}, issn = {}, eissn = {2564-6567}, address = {hırkai şerif mah. keçeci çeşmesi sok. doktorlar sitesi b blok 6/7 Fatih İstanbul Türkiye}, publisher = {Mustafa HASBAHÇECİ}, year = {2017}, volume = {2}, pages = {66 - 70}, doi = {10.25000/acem.336837}, title = {Plasma Urotensin II Concentration In Gestational Diabetes}, key = {cite}, author = {HURSİTOGLU, Mehmet and EKİZ, Ali and METE, Fatih and OKUTURLAR, Yıldız and KOCOGLU, Hakan and DUMANLİ, Guleren and CAKİRCA, Mustafa and ANATACA, Gulden and KURU, Oguzhan and DOGAN, Serkan and PEHLİVAN, Bahar and TABAK, Omur and Yildirim, Gokhan and Dogan, Hakan and Erismis, Betul} }
APA HURSİTOGLU, M , EKİZ, A , METE, F , OKUTURLAR, Y , KOCOGLU, H , DUMANLİ, G , CAKİRCA, M , ANATACA, G , KURU, O , DOGAN, S , PEHLİVAN, B , TABAK, O , Yildirim, G , Dogan, H , Erismis, B . (2017). Plasma Urotensin II Concentration In Gestational Diabetes. Archives of Clinical and Experimental Medicine , 2 (3) , 66-70 . DOI: 10.25000/acem.336837
MLA HURSİTOGLU, M , EKİZ, A , METE, F , OKUTURLAR, Y , KOCOGLU, H , DUMANLİ, G , CAKİRCA, M , ANATACA, G , KURU, O , DOGAN, S , PEHLİVAN, B , TABAK, O , Yildirim, G , Dogan, H , Erismis, B . "Plasma Urotensin II Concentration In Gestational Diabetes". Archives of Clinical and Experimental Medicine 2 (2017 ): 66-70 <https://dergipark.org.tr/en/pub/acem/issue/32027/336837>
Chicago HURSİTOGLU, M , EKİZ, A , METE, F , OKUTURLAR, Y , KOCOGLU, H , DUMANLİ, G , CAKİRCA, M , ANATACA, G , KURU, O , DOGAN, S , PEHLİVAN, B , TABAK, O , Yildirim, G , Dogan, H , Erismis, B . "Plasma Urotensin II Concentration In Gestational Diabetes". Archives of Clinical and Experimental Medicine 2 (2017 ): 66-70
RIS TY - JOUR T1 - Plasma Urotensin II Concentration In Gestational Diabetes AU - Mehmet HURSİTOGLU , Ali EKİZ , Fatih METE , Yıldız OKUTURLAR , Hakan KOCOGLU , Guleren DUMANLİ , Mustafa CAKİRCA , Gulden ANATACA , Oguzhan KURU , Serkan DOGAN , Bahar PEHLİVAN , Omur TABAK , Gokhan Yildirim , Hakan Dogan , Betul Erismis Y1 - 2017 PY - 2017 N1 - doi: 10.25000/acem.336837 DO - 10.25000/acem.336837 T2 - Archives of Clinical and Experimental Medicine JF - Journal JO - JOR SP - 66 EP - 70 VL - 2 IS - 3 SN - -2564-6567 M3 - doi: 10.25000/acem.336837 UR - https://doi.org/10.25000/acem.336837 Y2 - 2017 ER -
EndNote %0 Archives of Clinical and Experimental Medicine Plasma Urotensin II Concentration In Gestational Diabetes %A Mehmet HURSİTOGLU , Ali EKİZ , Fatih METE , Yıldız OKUTURLAR , Hakan KOCOGLU , Guleren DUMANLİ , Mustafa CAKİRCA , Gulden ANATACA , Oguzhan KURU , Serkan DOGAN , Bahar PEHLİVAN , Omur TABAK , Gokhan Yildirim , Hakan Dogan , Betul Erismis %T Plasma Urotensin II Concentration In Gestational Diabetes %D 2017 %J Archives of Clinical and Experimental Medicine %P -2564-6567 %V 2 %N 3 %R doi: 10.25000/acem.336837 %U 10.25000/acem.336837
ISNAD HURSİTOGLU, Mehmet , EKİZ, Ali , METE, Fatih , OKUTURLAR, Yıldız , KOCOGLU, Hakan , DUMANLİ, Guleren , CAKİRCA, Mustafa , ANATACA, Gulden , KURU, Oguzhan , DOGAN, Serkan , PEHLİVAN, Bahar , TABAK, Omur , Yildirim, Gokhan , Dogan, Hakan , Erismis, Betul . "Plasma Urotensin II Concentration In Gestational Diabetes". Archives of Clinical and Experimental Medicine 2 / 3 (December 2017): 66-70 . https://doi.org/10.25000/acem.336837
AMA HURSİTOGLU M , EKİZ A , METE F , OKUTURLAR Y , KOCOGLU H , DUMANLİ G , CAKİRCA M , ANATACA G , KURU O , DOGAN S , PEHLİVAN B , TABAK O , Yildirim G , Dogan H , Erismis B . Plasma Urotensin II Concentration In Gestational Diabetes. ACEM. 2017; 2(3): 66-70.
Vancouver HURSİTOGLU M , EKİZ A , METE F , OKUTURLAR Y , KOCOGLU H , DUMANLİ G , CAKİRCA M , ANATACA G , KURU O , DOGAN S , PEHLİVAN B , TABAK O , Yildirim G , Dogan H , Erismis B . Plasma Urotensin II Concentration In Gestational Diabetes. Archives of Clinical and Experimental Medicine. 2017; 2(3): 70-66.