Gestasyonel Diyabette Plazma Ürotensin II Konsantrasyonu

Year 2017, Volume: 2 Issue: 3, 66 - 70, 01.12.2017

Mehmet Hursitoglu Ali Ekiz Fatih Mete Yıldız Okuturlar Hakan Kocoglu Guleren Dumanli Mustafa Cakirca Gulden Anataca Oguzhan Kuru Serkan Dogan Bahar Pehlivan Omur Tabak Gokhan Yildirim Hakan Dogan Betul Erismis

https://doi.org/10.25000/acem.336837

Cited By: 1

Abstract

Amaç: Urotensin II
(UII) ve sistemi, birçok hastalığın (diyabet dahil) etyolojisinde rol oynar. Bu
çalışmada gestasyonel diabetes mellitusta (GDM) UII'yi değerlendirmek ve karşılaştırmayı
denedik.

Yöntemler: Çalışmaya alınan
otuzaltı gebe (GDM olmayan 15 kadın hasta 1. Grubu ve 21 GDM kadın hasta 2.
Grubu  oluşturdu). Üçüncü grup, yaşları eşleştirilmiş
22 gebe olmayan sağlıklı bireyden oluşuyordu. Plazma UII seviyeleri çalışmanın başında
belirlendi. Doğum sonrası 12.hafta ikinci bir plazma UII düzeyi grup 1 ve 2
'deki hastalardan ölçüldü.

Bulgular: Hem GDM
hem de GDM olmayan deneklerin Gestasyonel UII düzeyleri, gebe olmayan sağlıklı kontrollere
göre daha yüksekti (her ikisi için p=0,0001). GDM'li hastaların gestasyonel ve
postpartum UII düzeyleri, GDM'li olmayan gebelere göre daha yüksekti ancak istatistiksel
olarak anlamlı değildi (p≥0.05). GDM'li olmayan kişilerde plazma UII konsantrasyonları,
doğumdan sonra anlamlı olarak azaldı, ancak GDM'li kişilerde değişmedi (sırasıyla,
p=0,036 ve p ≥0.05).

Sonuç: GDM
hastalarında doğumdan sonra anlamlı bir şekilde azalmayan plazma UII
konsantrasyonlarının yüksek bulunması (GDM olmayan bireylerle karşılaştırıldığında),
UII'nin ve sisteminin GDM patogenezinde rol oynayabileceğini göstermektedir. Bu
alanda daha ayrıntılı çalışmalara ihtiyaç vardır.

Keywords

ürotensin, gestasyonel diabet, gebelik, glukoz tolerans testi

Plasma Urotensin II Concentration In Gestational Diabetes

Abstract

Aim: Urotensin II
(UII) and its system is implicated in the etiology of many diseases (including diabetes
mellitus). We tried in this study to evaluate and compare UII levels in
gestational diabetes mellitus (GDM).

Methods: Thirty-six
pregnant women (15 non-GDM patients consisted group 1 and 21 GDM patients
consisted group 2) enrolled in this study. The 3rd group consisted of age matched
22 non pregnant healthy women. Plasma UII levels were determined at the
beginning of the study. After 12 weeks of delivery, a second plasma UII was determined
from group 1 and 2.

Results: Gestational
UII levels of both GDM and non-GDM patients were higher than non-pregnant
healthy controls (p=0.0001 for both). Both gestational and postpartum UII
levels of GDM patients were higher than non-GDM patients but had not reached statistical
significance (P≥0.05). Plasma UII concentrations in non-GDM patients significantly
decreased after delivery but not in GDM patients (p=0.036 and p≥0.05,
respectively).

Conclusion: The
finding of elevated gestational plasma UII concentrations in GDM patients which
did not decrease significantly after delivery (in compare to non-GDM patients) shows
that plasma UII levels may have a role in the pathogenesis of GDM. Further
detailed studies are needed in this field.

Keywords

urotensin, gestational diabetes, pregnancy, glucose tolerance test

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