Determination of galectin-3, hepsin and thyroid transcription factor-1 levels in thyroid cancer patients; A prospective case-control study

Year 2019, Volume: 4 Issue: 3, 127 - 131, 01.12.2019

Ufuk Memiş Erdem Karadeniz Müfide Nuran Akçay Nurinnisa Öztürk

https://doi.org/10.25000/acem.568773

Abstract

Aim:We
aimed to evaluate the usage of Galectin-3, Hepsin andTTF-1 levels as a marker
for the differentiation of malignant and benign in patients with thyroid
nodules.

Metods:Study was done
prospectively between January 2018 and April 2018 in the our clinic, in
patients planned for operation due to thyroid nodule. Galectin-3, Hepsin
andTTF-1 levels were measured in the pre-operative serum of the benign and
malign groups. The measured levels are evaluated statistically to determine
whether there was any significant difference between malignant and benign
groups.

Results:When the levels of Galectin-3, Hepsin andTTF-1 in the malign
and benign group were compared; There was a statistically significant
difference inTTF-1 levels(p = .038), no significant difference was found in
Hepsin and Galectin-3. When the macropapillary and micropapillary types were
compared in the malign patient group, there was a significant difference
between the Galectin-3 levels(p = .009), but no difference was found between
Hepsin andTTF-1.

Conclusions:It was seen that the decrease of Galectin-3 level in thyroid
papillary carcinoma could be effective in transformation from micro carcinoma
to macro carcinoma, andTTF-1 could be an important marker at the
differentiation between benign and  malign
in thyroid nodules

Keywords

Galectin-3, Hepsin, TTF-1, Thyroid malignancy

Project Number

TTU-2018-6644

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