Case Report
Rare occurrence of coexistent squamous cell carcinoma and basal cell carcinoma in a case of Xeroderma Pigmentosum
Abstract
Xeroderma Pigmentosum is an inherited disorder of DNA repair characterised by defective nucleotide excision repair, which is involved in repairing ultraviolet rays induced cross linking of pyramidine residues. Affected individuals are at increased risk of development of mucocutaneous cancers at a much earlier age than normal. This genodermatosis affects both sexes and all races. The incidence in India is still unknown. We report one such case of a nine year old boy with co-existent squamous cell carcinoma and basal cell carcinoma of the face.
References
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Year 2020,
Volume: 5 Issue: 2, 90 - 92, 31.08.2020
Abstract
References
- 1.Weedon D.Weedon’s skin pathology.3rd ed. Churchill Livingstone Elsevier.Philadelphia.2010:p.274-76.
- 2.Black JO. Xeroderma Pigmentosum. Head Neck Pathol. 2016;10(2):139–144. doi:10.1007/s12105-016-0707-8.
- 3. Irvine AD, Mellerio JE. In: Burns T, Breathnach S, Cox N,Griffiths C (editors).Rook’s Textbook of Dermatology. 8th ed.Wiley Blackwell.West Sussex,UK.2010:p.15.70-15.74.
- 4.Tamhankar PM, Iyer SV, Ravindran S, Gupta N, Kabra M, Nayak C, et al. Clinical profile and mutation analysis of xeroderma pigmentosum in Indian patients. Indian J Dermatol Venereol Leprol 2015;81:16-22.
- 5. Kumar V, Abbas AK, Aster JC. Robbins and Cotran Pathologic Basis of Disease.9th ed.Elsevier Saunders. Philadelphia.2015:p.314-15.
- 6.DiGiovanna JJ, Kraemer KH. Shining a light on xeroderma pigmentosum. J Invest Dermatol. 2012;132:785–96.
- 7. Prabhu VV, Kale S, More S. Xeroderma pigmentosum: Composite cutaneous malignancies A nightmare. Indian J Paediatr Dermatol 2015;16:142-5.
- 8.Halkud R, Shenoy AM, Naik SM, Chavan P, Sidappa KT, Biswas S. Xeroderma pigmentosum: clinicopathological review of the multiple oculocutaneous malignancies and complications. Indian J Surg Oncol. 2014;5(2):120–124.
- 9.Chaudhary M, Jajoo SN, Agarwal R (2012) Xeroderma Pigmentosum: A Case Report of Two Siblings. J Immunodefic Disor 1:2.
There are 9 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Surgery |
| Journal Section | Case Report |
| Authors | |
| Publication Date | August 31, 2020 |
| Published in Issue | Year 2020 Volume: 5 Issue: 2 |
