Laparoskopik sleeve gastrektomi sonrası probiyotik takviyesinin konstipasyon ve gastrointestinal yaşam kalitesi üzerine etkisi

Year 2021, Volume: 6 Issue: 3, 117 - 122, 09.12.2021

Nida Yıldız Murat Baş Halil Coşkun Nazlı Batar Erkan Yardımcı

Abstract

Amaç: Bu çalışmada, Laparoskopik Sleeve Gastrektomi (LSG) sonrası probiyotik takviyesinin, konstipasyon ve gastrointestinal yaşam kalitesi üzerine erken dönem etkisinin araştırılması amaçlanmıştır.
Yöntemler: Bu çalışma, prospektif, randomize klinik çalışmadır. Katılımcıları Bariatriklab Obezite ve Metabolik Cerrahi Merkezi’ne LSG için başvuran bireyler oluşturmaktadır. Tüm hastalar, basit randomizasyon kullanılarak randomize örnekleme ile probiyotik ve kontrol olmak üzere 2 gruba ayrıldı. Probiyotik grubu, LSG sonrası 6 hafta boyunca probiyotik takviyesi olarak Bifidobacterium animalis lactis BB-12 suşunu kullandı. Hastaların, LSG öncesi ve sonrası 2.hafta, 4.hafta, 6.haftanın sonunda Gastrointestinal Semptom Derecelendirme Ölçeği (GSRS), Konstipasyon Ciddiyet Ölçeği (CSI), Konstipasyon Yaşam Kalitesi Ölçeği (PAC-QOL), Bristol Dışkı Formu Skalası (BSFS), Gastrointestinal Yaşam Kalitesi İndeksi (GIQLI) kaydedildi.
Bulgular: Probiyotik grubun yaş ortalaması 37,00±8,92 (18 kadın, 12 erkek), kontrol grubunun yaş ortalaması 41,03±11,29 (23 kadın, 7 erkek) idi. CSI (16,50 ± 14,76 ile 31,37 ± 15,34), PAC-QOL (58,53 ± 12,59 ile 72,30 ± 19,70), GSRS (26,83 ± 9,14 ile 37,93 ± 16,59) ve toplam puan ortalaması kontrol grubuna göre daha düşük, GIQLI toplam puan ortalaması (147,50 ± 11,79 ile 136,87 ± 18,98) daha yüksek bulundu (p <0,05).
Sonuç: LSG sonrası erken dönemde probiyotik takviyesi alan grupta, kontrol grubuna kıyasla konstipasyon ve gastrointestinal yaşam kalitesinde iyileşmeler gözlenmiştir.

Keywords

Bariatrik cerrahi, gastrointestinal yaşam kalitesi, konstipasyon, sleeve gastrektomi, probiyotik

Effect of probiotic supplementation after laparoscopic sleeve gastrectomy on constipation and gastrointestinal quality of life

Abstract

Aim: In this study, we aimed to investigate the early effect of probiotic supplementation after Laparoscopic Sleeve Gastrectomy (LSG) on constipation and gastrointestinal quality of life compared to control group.
Methods: This study was a prospective, randomized clinical trial. Participants were recruited to Bariatriklab Obesity and Metabolic Surgery Center for LSG. All patients were divided into 2 groups as probiotic and control by using simple randomization. The probiotic group consumed Bifidobacterium animalis lactis BB-12 strain as a probiotic supplement during 6 weeks after LSG. Gastrointestinal Symptom Rating Scale (GSRS), Constipation Severity Instrument (CSI), Patient Assessment of Constipation Quality of Life Scale (PAC-QOL), Bristol Stool Form Scale (BSFS), Gastrointestinal Quality of Life Index (GIQLI) of the patients were recorded before LSG and at the 2nd, 4th, 6th weeks after LSG.
Results: The probiotic group had an average age of 37.00±8.92 years (18 female, 12 male), the control group had an average age of 41.03±11.29 years (23 female, 7 male). CSI (16.50 ± 14.76 vs. 31.37 ± 15.34), PAC-QOL (58.53 ± 12.59 vs 72.30 ± 19.70), GSRS (26.83 ± 9.14 vs. 37.93 ± 16.59) and total score mean were lower compared to the control group, GIQLI total score average (147.50 ± 11.79 vs 136.87 ± 18.98) was found higher (p <0.05) in probiotic group.
Conclusion: Probiotic supplementation improved the constipation and gastrointestinal quality of life in the early post-LSG period in the probiotic group compared to the control group.

Keywords

Bariatric surgery, gastrointestinal quality of life, constipation, sleeve gastrectomy, probiotics

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