Effect of specific immunotherapy on plasma interleukin 13 and 8 levels in patients with allergic rhinitis
Abstract
Introductıon: This study aimed to evaluate interleukin (IL)-13 and IL-8 levels in patients with allergic rhinitis who were and were not receiving specific immunotherapy.
Methods: A total of 84 patients being followed up in the immunology-allergy outpatient clinic for allergic rhinitis (42 receiving immunotherapy) and 23 healthy control subjects were included. Serum IL-13 and IL-8 levels were measured by enzyme-linked immunosorbent assay in all groups.
Allergic rhinitis patients were also evaluated in terms of symptom scores, IgE levels, and skin prick test results.
Results: Comparison of serum IL-13 and IL-8 among the groups demonstrated that levels of both cytokines were significantly higher in both allergic rhinitis patient groups compared to controls (p<0.001), and significantly higher in symptomatic allergic rhinitis patients compared to patients receiving immunotherapy (p<0.001 for IL-13, p=0.004 for IL-8).
Conclusion: Immunotherapy is the only curative treatment for allergic rhinitis. The results of our study suggest that immunotherapy exerts its effect by modifying levels of IL-13 and IL-8 in addition to previously well-known cytokines.
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Details
| Primary Language | English |
|---|---|
| Subjects | Traditional, Complementary and Integrative Medicine (Other) |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | September 27, 2024 |
| Submission Date | July 10, 2024 |
| Acceptance Date | September 25, 2024 |
| Published in Issue | Year 2024 |