Heavy hemolysis after organophosphate poisoning by chlorpyrifos ethyl
Abstract
Organophosphates (OPs) inactivate the acetylcholinesterase enzyme, thus increasing the cholinergic effect. In a clinical setting, patients with OP poisoning may experience nausea and vomiting, diarrhea, and abdominal pain, or in severe cases respiratory failure, seizures, and death. Rarely, acute hemolysis has also been observed. The existing literature contains few descriptions of several delayed diseases associated with OP poisoning. This article presents the case of a patient who experienced severe hemolysis approximately one week after OP exposure. Only a small number of similar cases have been previously examined.
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References
- 1. Yılmaz M, Sebe A, Ay MO, Gürger M. Organophosphate Poisoning and Intermediate Syndrome. AKTD. 2016; 25(1): 70-83.
- 2. Kadeli D and S.Y. Hanjagi. Hemolysis Caused by Chlorpyriphos Consumption. JCR 2014;4(1):203-5.
- 3. Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, et al. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol. 2008;38 Suppl 2:1-125.
- 4. Bagchi D, Bagchi M, Hassoun EA, Stohs SJ. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 1995; 104: 129-40.
- 5. Timchalk C, Busby A, Campbell JA, Needham LL, Barr DN. Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat. Toxicology 2007; 237: 145-57.
- 6. Ladell WS. Physiological and clinical effects of organophosphorus compounds. Proc R Soc Med 1961;54:405-6.
- 7. Ngamdu YB, Sandabe MB, Kodiya AM, Isa A, Garandawa HI. Sudden Anosmia due to Otapiapia (Organophosphate Pesticide) Exposure. JCR. 2012;2(2):8-9.